Advanced Processes to Fabricate Scaffolds for Tissue Engineering

Bartolo, Paulo Jorge Da Silva; Almeida, Henrique A.; Rezende, Rodrigo Alvarenga; Laoui, Tahar; Bidanda, Bopaya

doi:10.1007/978-0-387-68831-2_8

Cited by 34 publications

(33 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such scaffolds should ideally be stimulatory, as well as biocompatible, degradable, and designed according to specific requirements to create a highly porous structure with interconnected pores [1,2,3]. These characteristics can provide an appropriate environment for cells and play an important role as a physical substrate for cell attachment, proliferation, and differentiation, as well as integration to the host tissue in order to regenerate the defect [4,5,6]. Although some new methods using shape memory materials, such as bioprinting and 4D printing, are under development [7,8,9,10], they are very much at infancy and less mature than scaffold technology.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Hydrophilicity and Cell Attachment of 3D Printed PCL/Graphene Scaffolds for Bone Tissue Engineering

et al. 2016

View full text Add to dashboard Cite

Scaffolds are physical substrates for cell attachment, proliferation, and differentiation, ultimately leading to the regeneration of tissues. They must be designed according to specific biomechanical requirements, i.e., certain standards in terms of mechanical properties, surface characteristics, porosity, degradability, and biocompatibility. The optimal design of a scaffold for a specific tissue strongly depends on both materials and manufacturing processes, as well as surface treatment. Polymeric scaffolds reinforced with electro-active particles could play a key role in tissue engineering by modulating cell proliferation and differentiation. This paper investigates the use of an extrusion-based additive manufacturing system to produce poly(ε-caprolactone) (PCL)/pristine graphene scaffolds for bone tissue applications and the influence of chemical surface modification on their biological behaviour. Scaffolds with the same architecture but different concentrations of pristine graphene were evaluated from surface property and biological points of view. Results show that the addition of pristine graphene had a positive impact on cell viability and proliferation, and that surface modification leads to improved cell response.

show abstract

Section: Introductionmentioning

confidence: 99%

Enhancing the Hydrophilicity and Cell Attachment of 3D Printed PCL/Graphene Scaffolds for Bone Tissue Engineering

et al. 2016

View full text Add to dashboard Cite

show abstract

“…[29][30][31] SLA is a rapid prototyping technique that uses photopolymerization to create threedimensional (3D) scaffolds layer by layer to a design specification that is input via computer. [32][33][34] This method will enable scaffolds to be reproduced with controlled porosity, pore size, interconnectivity, and mechanical properties, all of which greatly influence osteogenic signaling and differentiation. Therefore, this review will (1) discuss the influence of scaffold construct parameters on in vitro osteogenic signaling and in vivo bone formation and (2) evaluate SLA as a manufacturing technology to fabricate scaffolds to meet the requirements set forth in the literature.…”

mentioning

confidence: 99%

Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression

Kim

Yeatts

Dean

et al. 2010

Tissue Engineering Part B: Reviews

217

142

View full text Add to dashboard Cite

“…Skalak and Fox (1988), defined Tissue Engineering as the "application of the principles and methods of engineering and life sciences toward the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain, or improve tissue and organ functions" (Bártolo et al, 2008). The main reason for the appearance of this new research domain that rapidly expanded was to address the organ shortage problem that comprises not only full organs to be substituted by the damaged ones, as well as to regenerate tissues and gene therapy (Table 1).…”

Section: Introductionmentioning

confidence: 99%

“…Bhumiratana and Vunjak-Novakovic (2012), Norotte et al (2009), Bártolo et al (2008, Matsumoto and Mooney (2006), Mistry and Mikos, (2005), Fuchs et al (2001), Langer (1997) and Langer and Vacanti (1993). i. Cell-based strategies, consists in the implantation, in vivo, of isolated cells or cells substitutes so that they may synthesize their own Extracellular Matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Relationship between implant primary stability (torque and ISQ) and bone density assessed by CBCT—clinical trial

2014

Biodental Engineering III

View full text Add to dashboard Cite

AgradecimentosAo Professor Doutor Henrique Almeida, meu orientador e grande amigo, a quem agradeço a sua generosa paciência, exigência e ambição. Os contínuos estímulos para prosseguir este trabalho e o contínuo apoio moral e cientifico foram sempre determinantes para que continuasse a desenvolver esta dissertação. Agradeço profundamente a amizade com que me prendou durante todos estes anos do meu percurso académico e profissional, que revelam uma pessoa dedicada, competente e honesta.Ao Professor Doutor Paulo Bártolo, meu co-orientador, meu amigo, meu chefe e meu exemplo pessoal e profissional. Palavras são parcas para descrever o meu profundo agradecimento não só pelo constante apoio profissional e académico bem como pessoal. Agradeço todas as orientações científicas que me deu na realização deste trabalho bem como todo o rigor e contributo crítico ao longo de toda a minha vida profissional e académica. A sua constante disponibilidade para me auxiliar tornam todas as minhas etapas sempre mais fáceis de superar.Agradeço a todos os meus familiares e amigos por todo o apoio, contributo e incentivo prestado e por estarem sempre presentes quando mais preciso e principalmente por compreenderem os meus momentos de constante ausência. Agradeço especialmente ao André Vieira, Joana Maia, João Pascoal, Carolina Luís, Paulo Carvalho, Tânia Luís, Sérgio Santos, Vítor Hugo, Jair Cruz e Ruben Santos por estarem sempre presentes, mesmo sem pedir nada em troca (às vezes).À Ana Rita por todo o apoio e motivação em todo o meu percurso académico e profissional.Foi graças à sua extrema paciência e compreensão, especialmente quando mais tive ausente, e também do seu contínuo apoio ao longo de todos estes anos que foi possível chegar até aqui.Acreditou sempre no meu valor e deu-me sempre a força necessária para ir superando os meus obstáculos. Obrigado.Ao Alexandre, meu irmão e meu melhor amigo. Por me apoiar incondicionalmente e perdoar todos os meus momentos de ausência. Por me apoiar mesmo sem palavras. Agradeço a boa disposição e acima de tudo o amor de "maninho" com que me presenteia diariamente. v DINO MIGUEL FERNANDES FREITASPor último, aos meus Pais, principalmente por estarem presentes. Por me apoiarem incondicionalmente e darem-me a força necessária para continuar a lutar pelo que quero. Por me alegrarem e animarem nos momentos mais difíceis e por nunca me deixarem baixar os braços acreditando sempre em mim e principalmente por me apoiarem no percurso que escolhi.Agradeço há minha mãe pela amizade de uma amiga e o amor de uma mãe. Agradeço ao meu pai pelos sacrifícios e determinação nas vitórias por quem ama.A todos, o meu mais sincero agradecimento. vi OPTIMIZATION OF A PERFUSION BIOREACTOR FOR TISSUE ENGINEERING ResumoA regeneração de tecidos e/ou de órgãos é a solução para colmatar a falta de órgãos e tecidos, tanto actualmente como num futuro próximo. Este domínio da medicina tem crescido bastante e tem substituído algumas terapias convencionais. Os seus principais objectivos são restaurar, manter ou melhorar as funçõe...

show abstract

Advanced Processes to Fabricate Scaffolds for Tissue Engineering

Cited by 34 publications

References 51 publications

Enhancing the Hydrophilicity and Cell Attachment of 3D Printed PCL/Graphene Scaffolds for Bone Tissue Engineering

Enhancing the Hydrophilicity and Cell Attachment of 3D Printed PCL/Graphene Scaffolds for Bone Tissue Engineering

Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression

Relationship between implant primary stability (torque and ISQ) and bone density assessed by CBCT—clinical trial

Contact Info

Product

Resources

About