Advanced primary breast cancer: assessment at mammography of response to induction chemotherapy.

Segel, Mark; Paulus, David D.; Hortobágyi, G. N.

doi:10.1148/radiology.169.1.3420282

Cited by 95 publications

(64 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chemotherapy-induced fibrosis has been shown to impair the evaluation of tumour by conventional radiological methods and physical examination (Cocconi et al, 1984;Segel et al, 1988). We also found that similar factors together with the presence of extensive DCIS limited to the interpretation of the MRI scans.…”

Section: Discussionmentioning

confidence: 69%

“…There is a poor correlation between the histological appearances of the tumour and measurements obtained by physical examination, mammography (MM) or ultrasonography (USS). Radiological assessment is least accurate in younger women who most often desire BCS because their breast tissue is more dense making it more difficult to distinguish invasive cancer from residual in situ carcinoma and chemotherapy-induced fibrosis (Cocconi et al, 1984;Segel et al, 1988, Vinnicombe, 1996.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Using MRI to plan breast-conserving surgery following neoadjuvant chemotherapy for early breast cancer

et al. 2008

View full text Add to dashboard Cite

Contrast-enhanced magnetic resonance imaging (MRI) was used to monitor the response of patients undergoing neoadjuvant chemotherapy for breast cancer with the aim of undergoing breast-conserving surgery (BCS). Patients were prospectively recruited to undergo MRI as well as conventional methods of clinical examination, mammography (MM) and ultrasonography (USS) and response was assessed by each of these methods. Thirty-two patients with primary breast cancer were recruited. Magnetic resonance imaging correlation with histopathological size (r ¼ 0.71) was superior to USS (r ¼ 0.65) and to MM where tumour size was not measurable following chemotherapy in 71% of patients. Magnetic resonance imaging had 87.5% sensitivity (95% CI ¼ 68 -97%) and 50% specificity (95% CI ¼ 16 -84%) for a PPV (positive predictive value) of 99.8% and NPV (negative predictive value) of 80% for the detection of residual invasive cancer. Magnetic resonance imaging displayed 80% sensitivity (95% CI ¼ 28.4 -99.5%) and 89% specificity (95% CI ¼ 71 -98%) to detect pathological pCR in the breast. Eighty-four per cent of recruited patients were identified as potentially suitable candidates for BCS following chemotherapy and of those choosing to accept BCS, breast conservation was achieved in 90.5%, or 65.6% of all patients. Of those who proceeded to BCS, 9.5% required a re-do mastectomy because of positive margins; however, no residual tumour was found on histological examination of mastectomy specimens. Magnetic resonance imaging appears to be superior to conventional methods for assessing pathological response and the low rate of re-operation for positive margins indicates a valuable role in aiding the decision to undergo BCS or mastectomy.

show abstract

Section: Discussionmentioning

confidence: 69%

mentioning

confidence: 99%

Using MRI to plan breast-conserving surgery following neoadjuvant chemotherapy for early breast cancer

et al. 2008

View full text Add to dashboard Cite

show abstract

“…2 Mammography has been used widely for breast cancer screening, but it is difficult to diagnose breast cancers for breasts with high mammographic density and/or micro-calcifications. 3 Ultrasound imaging has higher sensitivity than mammography in imaging dense breast but with low specificity in screening breast cancers. 4,5 Magnetic resonance imaging (MRI) was reported to have results correlated better with pathology findings than mammography and obtained promising results when dynamic contrast agents are applied.…”

Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Baikejiang

Zhang

2017

XST

View full text Add to dashboard Cite

Abstract. Diffuse optical tomography (DOT) has attracted attentions in the last two decades due to its intrinsic sensitivity in imaging chromophores of tissues such as hemoglobin, water, and lipid. However, DOT has not been clinically accepted yet due to its low spatial resolution caused by strong optical scattering in tissues. Structural guidance provided by an anatomical imaging modality enhances the DOT imaging substantially. Here, we propose a computed tomography (CT) guided multispectral DOT imaging system for breast cancer imaging. To validate its feasibility, we have built a prototype DOT imaging system which consists of a laser at the wavelength of 650 nm and an electron multiplying charge coupled device (EMCCD) camera. We have validated the CT guided DOT reconstruction algorithms with numerical simulations and phantom experiments, in which different imaging setup parameters, such as projection number of measurements and width of measurement patch, have been investigated. Our results indicate that an air-cooling EMCCD camera is good enough for the transmission mode DOT imaging. We have also found that measurements at six angular projections are sufficient for DOT to reconstruct the optical targets with 2 and 4 times absorption contrast when the CT guidance is applied. Finally, we have described our future research plan on integration of a multispectral DOT imaging system into a breast CT scanner.

show abstract

“…These techniques assess therapeutic effects by either over-or underestimating the extent of residual disease due to fibrosis or sampling error (2,6,(11)(12)(13)(14)(15)(16). Although histology is the gold standard, the histological correlation of response with all of the above-mentioned modalities is not satisfactory.…”

mentioning

confidence: 99%

Monitoring the therapeutic response of locally advanced breast cancer patients: Sequential in vivo proton MR spectroscopy study

Kumar

Jagannathan

Seenu

et al. 2006

Magnetic Resonance Imaging

View full text Add to dashboard Cite

PurposeTo evaluate the use of the water‐to‐fat (W‐F) value obtained from in vivo proton (1H) MR spectroscopy (MRS) as a response indicator of cytologically confirmed patients with locally advanced breast cancer (LABC), and to monitor the therapeutic response of such patients to neoadjuvant chemotherapy (NACT)Materials and MethodsSerial 1H MR spectra were recorded both before and after the completion of chemotherapy in 33 LABC patients (with infiltrating ductal carcinoma (IDC)) at 1.5T. In addition, spectra from normal breast tissues of 28 healthy volunteers were recorded.ResultsMalignant breast tissues showed elevated W‐F values compared to normal breast tissues of controls. Statistically significant higher pretherapy W‐F value (P < 0.01) was observed in patients compared to controls. In patients who received NACT resulting in the reduction of the primary tumor size, the W‐F value showed a decrease that was statistically significant (P < 0.01). Analysis of the MR data further indicates that the W‐F value had no correlation with the menstrual status of the patients. A comparison of pretherapy W‐F value with pretherapy tumor volume showed a fair correlation (P = 0.05), while the posttherapy W‐F value showed no such correlation with the posttherapy tumor volume.ConclusionThis study demonstrates that simple, conventional in vivo 1H MRS is a useful technique for monitoring the therapeutic response of breast cancer patients. The observed trend in the reduction of W‐F value provides a noninvasive response indicator to monitor the clinical outcome of locally advanced breast cancer patients to NACT J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.

show abstract

Advanced primary breast cancer: assessment at mammography of response to induction chemotherapy.

Cited by 95 publications

References 0 publications

Using MRI to plan breast-conserving surgery following neoadjuvant chemotherapy for early breast cancer

Using MRI to plan breast-conserving surgery following neoadjuvant chemotherapy for early breast cancer

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Monitoring the therapeutic response of locally advanced breast cancer patients: Sequential in vivo proton MR spectroscopy study

Contact Info

Product

Resources

About