Advanced oxidative and glycoxidative protein damage markers in the elderly with type 2 diabetes

Grădinaru, Daniela; Borșa, Claudia; Ionescu, Cristina; Margină, Denisa

doi:10.1016/j.jprot.2013.03.034

Cited by 73 publications

(62 citation statements)

References 58 publications

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“…[33][34][35] A number of studies have demonstrated lower levels of nitrite/nitrate plasma in diabetic patients compared to the healthy controls. 36,37 Diabetic patients often experience elevated glucose levels. A part of this glucose becomes incorporated into hemoglobin and is measured as glycosylated hemoglobin (HbA1c).…”

Section: Discussionmentioning

confidence: 99%

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Influence of glycemic control on some real-time biomarkers of free radical formation in type 2 diabetic patients: An EPR study

et al. 2017

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Section: Discussionmentioning

confidence: 99%

“…Glycosylated hemoglobin binds •NO very tightly in the form of nitrosothiols and any •NO that is formed cannot be easily released from red blood cells. 36,37 Limited release of •NO is one of the reasons for violating essential cellular functions. Since in our study (Fig.…”

Section: Discussionmentioning

confidence: 99%

Influence of glycemic control on some real-time biomarkers of free radical formation in type 2 diabetic patients: An EPR study

et al. 2017

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“…Several studies has pointed out that advanced oxidative protein products and oxidative stress markers increase in adult subjects with type 2 DM with and without micro/macrovascular complications [17,18]. GSH is present in all mammalian tissues at 1-10 mM concentrations (highest concentrations in liver) as the most abundant nonprotein thiol that defends against oxidative stress [19].…”

Section: Discussionmentioning

confidence: 99%

Estimation of plasma glutathione levels in NIDDM patients with and without cardiovascular disease

Vani

Hemanthkumar

2015

Int Jour of Biomed Res

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Diabetes mellitus is a group of metabolic derangements characterised by hyperglycemia resulting from defective insulin secretion or action or both. Persistent hyperglycemia generates reactive oxygen species causing oxidative damage to cells and various biomolecules. In this study the levels of reduced glutathione antioxidant were estimated in NIDDM patients with cardiovascular disease (n=50) by HPLC method and compared to healthy controls (n=50). The results indicated that plasma glutathione levels are significantly decreased showing that antioxidant defence is lowered in diabetic patients with cardiovascular complications.

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“…Several lines of evidence suggest a close relationship between inflammation and OS [55][56][57]. Indeed, various OS markers are up regulated in subjects with type 2 DM [58][59][60], where a chronic lowgrade inflammation state is present. Regimens with calorie-restricted diets have been reported to positively affect OS in obese and type 2 DM individuals via modulation of recognized OS markers.…”

Section: Vlcd and Osmentioning

confidence: 99%

Very Low-Calorie Diets in Type 2 Diabetes Mellitus: Effects on Inflammation, Clinical and Metabolic Parameters

Román-Pintos¹,

Villegas-Rivera²,

Cardona-Muñóz³

et al. 2018

Diabetes and Its Complications

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Type 2 diabetes mellitus (DM) is a chronic and multifactorial disease strongly linked to a low-grade inflammatory process. Thus far, type 2 DM is generally regarded as an incurable disease by common therapies. However, very low-calorie diet (VLCD) regimens have demonstrated beneficial and rapid effects on glucose metabolism in subjects with type 2 DM. These beneficial effects include improvement of diabetes complications, insulin sensitivity and reduction in glycaemia, glycated hemoglobin (HbA1C), and triglyceride levels. VLCD regimens commonly comprise no more than 800 kcal/day and are therefore associated with rapid weight loss in overweight and obese individuals. This group of diets positively affects local/systemic inflammation and oxidative stress (OS) by modulating inflammatory cytokines, adipokines and endogenous antioxidant levels. The investigation of VLCDs in the field of type 2 DM treatment is progressively augmenting due to the multiple benefits in cardiometabolic health of overweight/obese subjects with type 2 DM. Here, we gather and review the evidence regarding the role of inflammation and OS in individuals with type 2 DM under VLCD regimens.

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Advanced oxidative and glycoxidative protein damage markers in the elderly with type 2 diabetes

Cited by 73 publications

References 58 publications

Influence of glycemic control on some real-time biomarkers of free radical formation in type 2 diabetic patients: An EPR study

Influence of glycemic control on some real-time biomarkers of free radical formation in type 2 diabetic patients: An EPR study

Estimation of plasma glutathione levels in NIDDM patients with and without cardiovascular disease

Very Low-Calorie Diets in Type 2 Diabetes Mellitus: Effects on Inflammation, Clinical and Metabolic Parameters

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