Advanced Oxidation Protein Products, Ferrous Oxidation in Xylenol Orange, and Malondialdehyde Levels in Thyroid Cancer

Kosova, Funda; Çetin, Bahadır; Akıncı, Melih; Aslan, Sabahattin; Arı, Zeki; Sepici, Aylin; Altan, Nilgün; Çetin, Abdullah

doi:10.1245/s10434-007-9425-5

Cited by 29 publications

(26 citation statements)

References 12 publications

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“…The concentration of trace elements in the thyroid gland is higher than in other tissues (7) and it has been shown that the thyroid hormones do infl uence the metabolism of these elements (2,(8)(9)(10). Furthermore, changes in these elements were associated with development of goiter and other thyroid pathologies including cancer (7).…”

Section: Discussionmentioning

confidence: 99%

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Serum copper levels in benign and malignant thyroid diseases

Kosova

Çetin²,

Akıncı³

et al. 2012

BLL

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Abstract:Objective: To examine the changes in serum copper (Cu) levels in benign and malignant thyroid disease in humans. Background: Thyroid hormones infl uence the metabolism of trace elements including copper. Methods: 47 papillary thyroid cancer and 43 benign multinodular goitre patients who underwent total thyroidectomy and 37 healthy control subjects were included into this study. All of the patients and controls were females. Serum Cu levels were detected with atomic absorption spectrophotometer. Results: In the papillary thyroid cancer group serum level of Cu was 131.61±33.9 μg/dL before surgery and 120.81±30.4 μg/dL after 20 days from surgery. In the benign group serum Cu level was 84.75±12.1 μg/dL and 68.01±9.4 μg/dL postoperatively.These results were compared to healthy control's value of 105.87±10.68 μg/dL. In the papillary thyroid cancer group pre-and postoperative serum Cu level was signifi cantly higher when compared to control group (p<0.05). Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level(p<0.05), in which, it was still higher than the control(p<0.05). In the benign group pre-and postoperative serum Cu level was significantly lower than in the control group (p<0.05).Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level in the benign group (p<0.05). Conclusion: This is a pioneer study to examine serum Cu level in benign and malignant thyroid patients compared to controls. In our small groups serum Cu levels increased in malignant thyroid patients and decreased in the benign group (Tab. 1, Ref. 18 Trace elements are essential micro-nutrients both for humans and other organisms. They are crucial for many physiological processes and are involved in many pathologic changes in tissues (1). Thyroid hormones infl uence the metabolism of trace elements including copper (Cu) (2). Cu is important for the activity of the enzyme superoxide dismutase (SOD). Changes in the activity of this enzyme are consistent with the Cu serum levels (3). Cu was shown to be essential for cell division both in normal and cancerous tissue (4, 5). Although copper is an essential element for human and animals, a high concentration of Cu (above normal) could induce growth proliferation and cancer by damaging DNA with toxic free hydroxyl radicals (6).The present study was undertaken to investigate correlation of Cu serum levels in benign and malign thyroid diseases before and after surgery compared to controls. Materials and methodsThis is an age-and sex-matched case-control study, conducted at the Department of Medical Biochemistry of Celal Bayar University of Medicine and the Department of General Surgery of Ankara Oncology Hospital, Ankara, Turkey. The study was approved by the hospital Ethical committee. All the patients and the volunteers involved in the study have given informed consent. PatientsRecruitment of subjects was performed by convenience sampling at outpatient General Surgery Clinic of Oncology Hospital, Turkey by trained physicians. 47...

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, changes in these elements were associated with development of goiter and other thyroid pathologies including cancer (7). Trace elements are essential micro-nutrients both for humans and other organisms.…”

Section: Discussionmentioning

confidence: 99%

Serum copper levels in benign and malignant thyroid diseases

Kosova

Çetin²,

Akıncı³

et al. 2012

BLL

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“…Acute and chronic loud noise contact generates extreme free radicals and reason disorders that involve extraauditory body part such as neural cells, endocrine functions and cardiovascular homeostasis [17]. Accumulation of AOPPs has been described in many pathologie [18][19][20], also those connected with impaired carbohydrate metabolism [18,21]. These products create as a result of the action of free radicals on proteins and may act as inflammatory mediators triggering the oxidative "ignition" of neutrophiles, monocytes and T lymphocytes thus leading to up regulation and excessive motivation of dendritic cells [22].…”

Section: Resultsmentioning

confidence: 99%

The effect of increased levels of lead in serum on several antioxidants parameters assed among workers from a large private electrical generator company

Mehdi

Mehde

2014

Eur. J. Chem.

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KEYWORDSLead poisoning occurs when lead builds up in the body, regularly over a period of months or years. Insignificant amounts of lead can cause serious health complications. The main objective of this study is to determine the effect of gases rising from electric generators and the lead-induced oxidative stress and adversarial health properties by biochemical markers in Iraqi workers employed on the operation of diesel generators mainly increased lead poisoning symptoms. Serum lead, advanced oxidation protein products (AOPP), total antioxidant activity (TAA), malondialdehyde (MDA), and other biochemical parameters were analysed in fifty workers in a large private electrical generator. The results of the study showed a significant elevation in lead, AOPP and MDA activities in Iraqi workers employed on the operation of diesel generators in association to healthy control samples. The results showed that elevated serum lead has a significant correlation with oxidative stress, and biochemical markers that may be help to detect impairment in the body function in lead exposed workers. GSH MDA Lead AOPP Vitamin C Gases of electric generators

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“…Oxidative damage to cells and tissues could be manifested through the serum level of MDA as the lipid peroxidation marker (8) level in post-thyroidectomy was significantly lower compared to pre-thyroidectomy, and the healthy subjects still showed significantly higher levels of MDA. Higher levels of MDA could be attributed to the increased production of free radicals, exceeding the capacities of the antioxidant enzymes (23).…”

Section: Discussionmentioning

confidence: 99%

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

et al. 2018

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Background: Oxidative stress has been shown to be the most significant influential factor in cancer pathogenesis. Follicular cells are affected in papillary thyroid carcinoma (PTC), which is the most prevalent thyroid cancer associated with oxidative stress. As a noninvasive source of body metabolism, saliva has recently attracted the attention of researchers as an investigative specimen. The present study aimed to evaluate and compare the levels of total antioxidant capacity (TAC) and malondialdehyde (MDA) in the blood and saliva samples of PTC patients and healthy control subjects. Methods: This case-control study was conducted on the patients with PTC referring to Taleghani Hospital in Tehran, Iran. Age-and gender-matched healthy volunteers were selected as the control group. Blood and saliva samples were obtained from all the subjects. Measurement of the MDA and TAC levels was performed using a commercial kit (ZellBio GmbH, Germany) based on colorimetric methods. Data analysis was performed in MedCalc software version 14.8.1.

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Advanced Oxidation Protein Products, Ferrous Oxidation in Xylenol Orange, and Malondialdehyde Levels in Thyroid Cancer

Abstract: In conclusion, all of AOPP, FOX, and MDA levels that are markers of protein oxidation and lipid hyperoxidation may induce thyroid cancer development and begin to decrease after thyroidectomy.

Cited by 29 publications

References 12 publications

Serum copper levels in benign and malignant thyroid diseases

Serum copper levels in benign and malignant thyroid diseases

The effect of increased levels of lead in serum on several antioxidants parameters assed among workers from a large private electrical generator company

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

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