Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome

Kaya, Cemil; Erkan, Aycan Fahri; Cengiz, Sevim; Dünder, İlkkan; Demirel, Özlem; Bi̇lgi̇han, Ayşe

doi:10.1016/j.fertnstert.2008.08.016

Cited by 48 publications

(40 citation statements)

References 37 publications

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“…Studies have established an association between AOPPs and cardiovascular risk factors in PCOS women [37,38]. Plasma levels of AOPPs are significantly higher in PCOS women compared with the healthy controls.…”

Section: Oxidative Stress In Pcosmentioning

confidence: 99%

“…Stimulation of ROS generation by HG plays a critical role in the inflammation process through the release of TNF-a, a known mediator in IR and IL-6 that regulates IR by increasing serine phosphorylation of IRS-1. Further, TNF-a induces IR in healthy human subjects via inhibition of phosphorylation of Akt substrate of 160 [38]. This inhibition leads to reduced expression of glucose transporter type 4 (GLUT-4) which subsequently results in a decrease in glucose transport [64].…”

Section: Insulin Resistance In Pcosmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

Hyderali¹,

Kundabala²

2015

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Oxidative Stress In Pcosmentioning

confidence: 99%

Section: Insulin Resistance In Pcosmentioning

confidence: 99%

Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

Hyderali¹,

Kundabala²

2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Plasma advanced oxidation protein products are associated with oxidant-mediated protein damage that was shown to be higher in PCOS and was independently related to IR. It was associated with higher oxidative stress measures and elevated highly sensitive C-reactive protein (hs-CRP) while being unrelated to obesity (20); this may be a useful marker in studies with both obese and non-obese PCOS subjects. Others looked at ischemia-modified albumin (IMA) that reflects chronic hypoxia and oxidative stress, which was found to be elevated in PCOS.…”

Section: Cvr Markers In Bloodmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Sathyapalan

Atkin²

2012

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) has been associated with increased cardiovascular risk (CVR) markers, but population studies have not clarified whether there is an increase in cardiovascular morbidity and mortality. Four different PCOS phenotypes resulted from the Rotterdam criteria that may differ in their CVR potential, thus introducing further complexity. This has led to studies using surrogate CVR markers including biomarkers in blood and imaging such as flow-mediated vasodilatation. In PCOS, both peripheral and central insulin resistance (IR) have been shown. Weight loss has been shown to improve IR and visceral fat, while insulin sensitizer therapies with metformin or thiazolidinediones improve IR and endothelial dysfunction. IR is also found in non-alcoholic fatty liver disease that in turn is very common in PCOS; studies have suggested that IR may be improved by treatment with metformin and omega-3 fish oils. PCOS patients have a more dyslipidemic phenotype that is worse in 'classical PCOS' associated with a higher CVR. Studies with atorvastatin and simvastatin have reported a decrease in the lipid parameters and an improvement in CVR indices including IR, but it is unclear whether this is due to their lipid-lowering action or a pleiotropic effect of the statin. In this expert opinion review, the relevant literature published during the last 2 years was considered. It focuses on some recent important data that has emerged while also exposing the gaps that remain in our knowledge that need to be addressed.

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“…OS markers in PCOS patients, such as MDA, thiol, and blood zinc, are associated with whose fertility, the levels of MDA in infertility PCOS patients higher than that in pregnant PCOS patients, while the MAD, sulfhydryl and blood zinc content are lower [67][68][69][70][71]. Therefore, eat more fruits and vegetables containing antioxidants, increased intake of vitamins, avoid drinking, smoking and intake of caffeine to maintain the balance between oxidants and antioxidants in the body, so as to maintain the health female reproductive system, which improving female fertility.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…A study reported that the advanced oxidation protein products in women with PCOS were higher than that in health women with the same age and body mass index (BMI), while the total antioxidant levels were lower [67]. Previous studies suggested that OS is associated with obesity of PCOS patients, but recent studies have found elevated OS markers levels in lean PCOS patients [66].…”

Section: Oxidative Stressmentioning

confidence: 99%

Diagnosis, Pathogenesis and Management of Polycystic Ovary Syndrome

Wang¹

2017

Testes and Ovaries - Functional and Clinical Differences and Similarities

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Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine diseases occurs among women of childbearing age, which is affected by many factors, but its precise pathophysiology has not yet been determined. The heterogeneous of PCOS is reflected in its complex endocrine dysfunction of the hypothalamic-pituitarygonadal axis (HPG axis) and its multiple clinical features, such as obesity, insulin resistance, hyperandrogenism and anovulation. Meanwhile, women with PCOS also have an increased risk of major cardiovascular events, most notably type 2 diabetes, cardiovascular disease and atherosclerosis. So far, many therapies are available for improving reproductive and metabolic abnormalities in PCOS patients, in which lifestyle modification and insulin-sensitizing agents are more effective management strategies.

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Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome

Cited by 48 publications

References 37 publications

Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Diagnosis, Pathogenesis and Management of Polycystic Ovary Syndrome

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