Advanced Open-Celled Structures from Low-Temperature Sintering of a Crystallization-Resistant Bioactive Glass

Abstract

Most materials for bone tissue engineering are in form of highly porous open-celled components (porosity >70%) developed by means of an adequate coupling of formulations and manufacturing technologies. This paper is dedicated to porous components from BGMS10 bioactive glass, originally designed to undergo viscous flow sintering without crystallization, which is generally known to degrade the bioactivity of 45S5 bioglass. The adopted manufacturing technologies were specifically conceived to avoid any contamination and give excellent control on the microstructures by simple operations. More precisely, ‘green’ components were obtained by digital light processing and direct foaming of glass powders suspended in a photosensitive organic binder or in an aqueous solution, activated with an organic base, respectively. Owing to characteristic quite large sintering window of BGMS10 glass, sintering at 750 °C caused the consolidation of the structures generated at room temperature, without any evidence of viscous collapse.

A Review of Bioactive Glass/Natural Polymer Composites: State of the Art

“…Additionally, 45S5 Bioglass ® is osteoinductive and able to bond to both soft and hard tissues [34]. However, in recent years, many BGs have been developed, especially those containing the so-called therapeutic ions such as strontium and magnesium [35][36][37][38][39][40][41][42][43][44][45][46][47]. The addition of specific and therapeutic ions that are released during bioactive glass degradation [48,49] aims at enhancing specific cellular response in the host, favoring regenerative processes.…”

Incorporation of Bioactive Glasses Containing Mg, Sr, and Zn in Electrospun PCL Fibers by Using Benign Solvents

“…Generally, bioactive glasses have shown high bioactivity and high interaction with hard and soft tissues [14,15]. In this work, 45S5 BG (composition 45 wt% SiO 2 , 24.5 wt% CaO, 24.5 wt% Na 2 O, and 6.0 wt% P 2 O 5 ) [16], Sr-and Mg-substituted bioactive glass (BGMS10 [17][18][19][20][21][22][23]), and Zn-substituted bioactive glass (BGMS_2Zn [24]) were incorporated in PCL fibers by electrospinning technique. BGMS10 was designed starting from the composition of 45S5 by adding SrO and MgO; subsequently, ZnO was added to the BGMS10 composition to produce a Zn-substituted bioactive glass labelled as BGMS_2Zn [24].…”

Effects of a Novel Bioactive Glass Composition on Biological Properties of Human Dental Pulp Stem Cells

“…Moreover, the addition of therapeutic ions such as strontium and magnesium resulted in an improved biological response [ 12 ] also compared to 45S5 [ 13 ], as reported as well for other bioactive glasses containing Sr and Mg [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. BGMS10 resulted as suitable for the preparation of composites [ 21 ], dental putties [ 22 ], 3D printed scaffolds [ 23 ], wound dressings [ 24 , 25 ], and antibacterial systems [ 26 ], being very promising also compared to other bioactive glasses investigated in literature (e.g., [ 27 , 28 , 29 , 30 , 31 , 32 ]).…”