“…Therefore, we do not recommend the use of CSF as a reference region in intensity normalization. Furthermore, in addition to NAWM, several other regions have been shown to be diffusely affected by MS, including cerebellar white matter (CBWM) (Bonnier et al, 2014; Casanova et al, 2003; Deppe et al, 2015), cortical gray matter (Kutzelnigg et al, 2005; Pirko et al, 2007; Vrenken et al, 2006) and deep gray matter (Griffin et al, 2002; Parry et al, 2002; Pirko et al, 2007; Vrenken et al, 2006). …”