Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity

Tardif, Christine; Gauthier, Claudine; Steele, Christopher J.; Bazin, Pierre‐Louis; Schäfer, Andreas; Schaefer, Alexander; Turner, Robert; Villringer, Arno

doi:10.1016/j.neuroimage.2015.08.047

Cited by 110 publications

(117 citation statements)

References 283 publications

Supporting

Mentioning

108

Contrasting

Order By: Relevance

“…However, dMRI methods by themselves cannot distinguish amongst these possibilities (Jones and Cercignani 2010; De Santis et al 2014). Understanding the neurobiological properties contributing to these group differences will benefit from the combination of diffusion measures with other quantitative MRI methods for estimating myelin content or axonal diameter more directly (Assaf et al 2008; Mezer et al 2013; Tardif et al 2015; Travis, Golden, et al 2015). …”

Section: Discussionmentioning

confidence: 99%

White matter properties differ in 6-year old Readers and Pre-readers

et al. 2016

View full text Add to dashboard Cite

Reading, an essential life skill in modern society, is typically learned during childhood. Adults who can read show white matter differences compared to adults who never learned to read. Studies have not established whether children who can read show similar white matter differences compared to children who cannot read. We compared 6-year old children who could decode written English words and pseudowords (n=31; Readers) and 6-year old children who could not decode pseudowords and had a standard score < 100 on a task for reading single words (n=11; Pre-Readers). We employed diffusion MRI and tractography to extract fractional anisotropy (FA) along the trajectory of 6 bilateral intra-hemispheric tracts and 2 posterior subdivisions of the corpus callosum. Readers demonstrated significantly increased FA within the left anterior segment of the superior longitudinal fasciculus (aSLF-L) and the right uncinate fasciculus (UF-R) compared to Pre-Readers. FA in the aSLF-L was significantly correlated with phonological awareness; FA in the UF-R was significantly correlated with language. Correlations in the UF-R but not the aSLF-L remained significant after controlling for reading ability, revealing that UF-R group differences were related to both children's language and reading abilities. Taken together, these findings demonstrate new evidence showing that individual differences in white matter structure relate to whether children have begun to read.

show abstract

Section: Discussionmentioning

confidence: 99%

White matter properties differ in 6-year old Readers and Pre-readers

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Recent work has reported that the T1 signal is also sensitive to macromolecules (e.g., the proteins and lipids forming cellular membranes), water content of brain tissues, and to a lesser extent iron, and the T2 signal is sensitive to iron and deoxyhemoglobin content, in addition to myelin (Tardif et al, 2016). Most notably, myelin and inflammation both alter the signal intensity of T1w and T2w images in opposite directions, both contributing to an increase in T1w/T2w ratio values.…”

Section: Methodological Considerations and Limitationsmentioning

confidence: 99%

MR‐based age‐related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan

Tullo

Patel

Devenyi

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age‐related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and morphology (i.e., volume and shape), and microstructure (using the T1‐weighted/T2‐weighted [T1w/T2w] signal ratio as a putative index of myelin and microstructure) of the striatum, globus pallidus, and thalamus across the adult lifespan using a dataset carefully quality controlled, yielding a final sample of 178 for the morphological analyses, and 162 for the T1w/T2w analyses from an initial dataset of 253 healthy subjects, aged 18–83. In accordance with previous cross‐sectional studies of adults, we observed age‐related volume decrease that followed a quadratic relationship between age and bilateral striatal and thalamic volumes, and a linear relationship in the globus pallidus. Our shape indices consistently demonstrated age‐related posterior and medial areal contraction bilaterally across all three structures. Beyond morphology, we observed a quadratic inverted U‐shaped relationship between T1w/T2w signal ratio and age, with a peak value occurring in middle age (at around 50 years old). After permutation testing, the Akaike information criterion determined age relationships remained significant for the bilateral globus pallidus and thalamus, for both the volumetric and T1w/T2w analyses. Our findings serve to strengthen and expand upon previous volumetric analyses by providing a normative baseline of morphology and microstructure of these structures to which future studies investigating patients with various disorders can be compared.

show abstract

“…The aim is to allow greater inference about local tissue composition, for example the very short T 2 associated with myelin compared to other water within a voxel 43 .…”

Section: Microstructure -Mri At the Microscopic Levelmentioning

confidence: 99%

“…The main downside of quantitative T 1 and T 2 mapping is the significantly greater amount of time required for equivalent SNR and resolution, as the gold-standard methods require acquiring data at multiple echos or inversion times 43,44 . This is compounded by the general need to estimate multiple T 2 values within each voxel if one wants to map specific compartments like myelin.…”

Section: Microstructure -Mri At the Microscopic Levelmentioning

confidence: 99%

Studying neuroanatomy using MRI

et al. 2017

View full text Add to dashboard Cite

The study of neuroanatomy using imaging enables key insights into how our brains function, are shaped by genes and environment, and change with development, aging, and disease. Developments in MRI acquisition, image processing, and data modelling have been key to these advances. However, MRI provides an indirect measurement of the biological signals we aim to investigate. Thus, artifacts and key questions of correct interpretation can confound the readouts provided by anatomical MRI. In this review we provide an overview of the methods for measuring macro-and mesoscopic structure and inferring microstructural properties; we also describe key artefacts and confounds that can lead to incorrect conclusions. Ultimately, we believe that, though methods need to improve and caution is required in its interpretation, structural MRI continues to have great promise in furthering our understanding of how the brain works.

show abstract

Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity

Cited by 110 publications

References 283 publications

White matter properties differ in 6-year old Readers and Pre-readers

White matter properties differ in 6-year old Readers and Pre-readers

MR‐based age‐related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan

Studying neuroanatomy using MRI

Contact Info

Product

Resources

About