Advanced MRI Patterns of Muscle Disease in Inherited and Acquired Myopathies: What the Radiologist Should Know

Caetano, António; Alves, Pedro

doi:10.1055/s-0039-1684022

Cited by 12 publications

(13 citation statements)

References 109 publications

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“…Muscle MRI routinely used for myopathy patients helped recognize the specific involvement patterns in certain hereditary myopathy [ 27 , 28 , 29 ] and guided the location for a muscle biopsy to minimize the sampling bias [ 30 ]. The MRI protocol comprised four sequences: (a) axial view of T1-weighted image (T1WI) with fast spin-echo (FSE), (b) axial view of proton-density-weighted image (PDWI) with fat suppression and FSE, (c) coronal view of T2-weighted image (T2WI) with fat suppression and FSE, and (d) sagittal, axial, and coronal views, contrast-enhanced, T1WI with fat suppression and FSE.…”

Section: Methodsmentioning

confidence: 99%

Muscle Biopsy: A Requirement for Precision Medicine in Adult-Onset Myopathy

Liao

Lin

et al. 2022

JCM

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Muscle biopsy is a fundamental procedure to assist the final diagnosis of myopathy. With the recent advances in molecular diagnosis, serology tests, and mechanism-based classification in myopathy, the précised diagnosis for myopathy required the applications of multiple tools. This study intends to reappraise the benefit of muscle biopsy in adult-onset myopathy under the setting of an optimized muscle biopsy protocol and comprehensive serology tests. A one-group pretest-posttest study design was used. The pre- and post-biopsy diagnoses and treatments in 69 adult patients were compared. Muscle biopsy yielded 85.5% of definitive diagnoses, including changes in pre-biopsy diagnoses (40.6%) and narrowing down the suspicious myopathies (49.3%). The demographic data and clinical parameters between the group “with change” and “without change” after biopsy were not different. Among those with changes in diagnosis, 39.3% also had a corresponding shift in treatment, which benefits the patients significantly. Regarding the most common adult-onset myopathy, idiopathic inflammatory myopathy (IIM), 41% of patients with pre-biopsy diagnosis as IIM had changes in their IIM subtype diagnosis, and 53% was finally not IIM after muscle biopsy. Although there have been advances in molecular diagnosis recently, muscle biopsy still undoubtedly critically guided the diagnosis and treatment of adult-onset myopathy in the era of precision medicine.

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Section: Methodsmentioning

confidence: 99%

Muscle Biopsy: A Requirement for Precision Medicine in Adult-Onset Myopathy

Liao

Lin

et al. 2022

JCM

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“…Myopathy is associated with an infinite variety of infectious, inflammatory, traumatic, neurological, genetic, neoplastic, and iatrogenic conditions that can cause pain and disability, and, as such, specific imaging is required [ 3 - 5 ]. Although diverse, some diseases offending muscle share similar imaging appearances, whereas others present distinct patterns of imaging abnormality.…”

Section: Introductionmentioning

confidence: 99%

“…Not infrequently, clinical assessment of the integrity and performance of muscle is difficult owing to complex compartmental anatomy and numerous anatomic variations, making a presumptive diagnosis of skeletal muscle disease rely strongly on a clinical imaging correlation. Despite advanced imaging methods for muscle disease, biopsy remains the cornerstone of diagnosis that proves valuable in challenging, or indeterminate, cases [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Skeletal Muscle Disease: Imaging Findings Simplified

Theodorou¹,

Theodorou²,

Saba³

et al. 2022

Cureus

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Skeletal muscle is a major anatomic structural component of the human body. Myopathy, defined as skeletal muscle disease, may offend any of the body’s 650 muscles and encompasses an extended array of acute and chronic abnormalities. Muscle disease can be categorized according to etiology as congenital, traumatic, infectious, or neoplastic. The concept of the diversity of multiple muscular disease processes signifies an important role for imaging in the detection and characterization of myopathy. However, despite the exquisite physiological properties of skeletal muscle, muscle imaging has not received attention equal to that of bones and joints. Accordingly, this article provides an indication of the most suitable imaging modalities for myopathy and reviews a multitude of primary and systemic muscle derangements, with an emphasis on magnetic resonance (MR) imaging findings. Because these patterns of MR imaging abnormality bespeak the widespread nature of myopathy, we illustrate typical examples of muscle disease processes to simplify diagnosis.

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“…8 An important role of imaging is the identification of sites of muscle inflammation, which can then be targeted for muscle biopsy. 9 Currently, this is usually done by subjective visual assessment of the muscle, a technique that may be relatively insensitive to systemic muscle changes. As an alternative, there are a range of quantitative MRI techniques that can detect subtle muscle changes in muscle diseases and may have a role in the future clinical management of DM and PM, and the identification of sites for biopsy and the monitoring of response to treatment.…”

Section: Introductionmentioning

confidence: 99%

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

et al. 2021

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imaging (MRI)-based measurements of T2, fat fraction, diffusion tensor imaging, and muscle volume can detect differences between the muscles of myositis patients and healthy controls, and to identify how they compare with semi-quantitative MRI diagnosis. MATERIALS AND METHODS: Sixteen myositis patients and 16 age-and gender-matched healthy controls underwent MRI of their thigh. Quantitative MRI measurements and radiologists' semi-quantitative scores were assessed. Strength was assessed using an isokinetic dynamometer. RESULTS: Fat fraction and T2 values were higher in myositis patients whereas muscle volume was lower compared to healthy controls. There was no difference in diffusion. Muscle strength was lower in myositis patients compared to healthy controls. In a subgroup of eight patients, scored as unaffected by radiologists, T2 values were still significantly higher in myositis patients. CONCLUSIONS: Quantitative MRI measurements can detect differences between myositis patients and healthy controls. Changes in the muscles of myositis patients, undetected by visual, semi-quantitative scoring, can be detected using quantitative T2 measurements. This suggests that MRI T2 values may be useful for the management of myositis patients.

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Advanced MRI Patterns of Muscle Disease in Inherited and Acquired Myopathies: What the Radiologist Should Know

Cited by 12 publications

References 109 publications

Muscle Biopsy: A Requirement for Precision Medicine in Adult-Onset Myopathy

Muscle Biopsy: A Requirement for Precision Medicine in Adult-Onset Myopathy

Skeletal Muscle Disease: Imaging Findings Simplified

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

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