Advanced MRI in Rosai–Dorfman disease: Correlation with histopathology

Hingwala, Divyata Rajendra; Neelima, R; Kesavadas, Chandrasekharan; Kapilamoorthy, T.R.; Radhakrishnan, V. V.

doi:10.1016/j.neurad.2010.09.002

Cited by 14 publications

(9 citation statements)

References 8 publications

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“…Hypointensity in meningiomas on T2W images is usually secondary to the presence of calcifications, which reveals blooming on GRE/SW images. This feature has never been reported in RDD; suggesting that the presence of calcifications could prelude the diagnosis of intracranial RDD ( 18 ). Primary dural lymphomas may be difficult to distinguish from the dural-based lesions of RDD.…”

Section: Discussionmentioning

confidence: 91%

“…The presence of associated features such as plaque-like thickening of the meninges, early invasion of the underlying brain, and bone erosion may serve as clues to the diagnosis ( 19 ). Diffusion-weighted imaging may not aid differentiation from lymphoma as restricted diffusion may be encountered in RDD as well due to dense fibrosis within the lesions, limiting movement of water molecules ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

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Multimodality imaging manifestations of Rosai-Dorfman disease

Vaidya

Mahajan

Rane

2020

Acta Radiologica Open

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Background Rosai-Dorfman disease (RDD) is a rare lympho-histiocytic disorder of indeterminate etiology usually presenting with lymph node involvement, and infrequently with extra-nodal manifestations. The diagnosis of this condition is challenging due to the wide spectrum of disease manifestations. Purpose To elucidate the radiologic features of this disease using multimodality imaging in histopathologically proven cases and to identify characteristic features that would enable its differentiation from its mimics. Material and Methods We retrospectively evaluated imaging studies of 19 patients with histopathologically confirmed RDD presenting to our institute between January 2004 and March 2016. Imaging modalities included magnetic resonance imaging (MRI), computed tomography, FDG-positron emission tomography (PET) CT, mammography, and ultrasonography. Results Lymphadenopathy was the most common imaging feature in our study, seen in 11 (57.8%) cases followed by sino-nasal involvement in 7 (36.8%) cases and intracranial masses in 5 (26.3%) cases. Bilateral homogeneously enhancing cervical lymphadenopathy with avidity on FDG-PET scans was the predominant abnormality on imaging. Sino-nasal involvement manifested as homogeneously enhancing soft-tissue masses occupying the paranasal sinuses. Intracranial disease manifested as sellar/suprasellar masses, dural-based lesions along the cerebral hemispheres and choroid plexus enlargement. Unusual disease manifestations included spinal, osseous, and breast lesions. Conclusion Due to the high likelihood of multifocal involvement, the recognition of RDD at one site necessitates screening of other sites for disease. Homogeneously enhancing, FDG-avid lymphadenopathy and sino-nasal masses in association with hypointense extra-nodal lesions on T2-weighted MRI are imaging features which could aid the diagnosis of RDD and facilitate its differentiation from pathologies that present in a similar manner.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Multimodality imaging manifestations of Rosai-Dorfman disease

Vaidya

Mahajan

Rane

2020

Acta Radiologica Open

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“…However, use of newer imaging techniques like perfusion weighted imaging, diffusion weighted imaging and SWI can give additional information which can help in narrowing down the differential diagnosis. These are hypoperfused lesions which show abundant susceptibility and increased FA along with low ADC [14]. However, usefulness of these imaging features needs to be confirmed in a larger series of patients.…”

Section: Discussionmentioning

confidence: 99%

Rosai Dorfman disease: Case with extensive dural involvement and cerebrospinal fluid pleocytosis

Nalini

Saini

Anantaram

et al. 2012

Journal of the Neurological Sciences

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“…That feature might be important for differentiating the disease from meningiomas, hemangiopericytomas and solitary fibrous tumors of the meninges, which typically have markedly increased perfusion parameters. However, a recent report has shown that Rosai-Dorfman disease may also show increased perfusion due to its high positivity for CD34 and CD31 antibodies, which are surrogate markers for the intrinsic vascularization of lesions 23 . The natural history of Rosai-Dorfman disease remains uncertain, although most cases are benign and self-limited.…”

Section: Histopathologic Findingsmentioning

confidence: 99%

Histiocytosis: a review focusing on neuroimaging findings

Gabbay

Leite

Andriola

et al. 2014

Arq. Neuro-Psiquiatr.

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Objective: Histiocytosis is a systemic disease that usually affects the central nervous system. The aim of this study is to discuss the neuroimaging characteristics of Langerhans cell histiocytosis (LCH), the most common of these diseases; and the non-Langerhans cells histiocytosis (NLCH), which includes entities such as hemophagocytic syndrome, Erdheim-Chester and Rosai-Dorfman diseases. Method: Literature review and illustrative cases with pathologic confirmation. Results: In LCH, the most common findings are 1) osseous lesions in the craniofacial bones and/or skull base; 2) intracranial, extra-axial changes; 3) intra-axial parenchymal changes (white and gray matter); 4) atrophy. Among the NLCH, diagnosis usually requires correlation with clinical and laboratory criteria. The spectrum of presentation includes intraparenchymal involvement, meningeal lesions, orbits and paranasal sinus involvement. Conclusion: It is important the recognition of the most common imaging patterns, in order to include LCH and NLCH in the differential diagnosis, whenever pertinent.Keywords: Langerhans cells histiocytosis, non-Langerhans cells histiocytosis, Rosai-Dorfman, hemophagocytic syndrome, ErdheimChester. RESUMOObjetivo: Histiocitose é uma doença sistêmica que, frequentemente, acomete o sistema nervoso central. Este trabalho propõe discutir as características de neuroimagem da histiocitose de células de Langerhans (HCL), mais comum; e as histiocitoses não-Langerhans (HNL), como a síndrome hemofagocítica, doenças de Erdheim-Chester e Rosai-Dorfman. Método: Revisão de literatura, com demonstração de casos confirmados por anatomopatológico. Resultados: Na HCL os achados mais comuns são: 1) lesões ósseas craniofaciais e da base do crânio; 2) lesões intracranianas, extra-axiais; 3) acometimento parenquimatoso intra-axial na substância cinzenta ou branca; 4) atrofia. Dentre as HNL, o diagnóstico, em geral, exige correlação com critérios clínico-laboratoriais. O espectro de apresentação das mesmas inclui acometimento intraparenquimatoso, lesões meníngeas, envolvimento orbitário e das cavidades paranasais. Conclusão: É importante o reconhecimento dos padrões de imagem mais comuns, para que HCL e HNL sejam incluídas no diagnóstico diferencial, sempre que pertinente.

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Advanced MRI in Rosai–Dorfman disease: Correlation with histopathology

Cited by 14 publications

References 8 publications

Multimodality imaging manifestations of Rosai-Dorfman disease

Multimodality imaging manifestations of Rosai-Dorfman disease

Rosai Dorfman disease: Case with extensive dural involvement and cerebrospinal fluid pleocytosis

Histiocytosis: a review focusing on neuroimaging findings

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