Advanced MR Imaging of the Human Nucleus Accumbens—Additional Guiding Tool for Deep Brain Stimulation

Neto, Lia Lucas; Reimão, Sofia; Oliveira, Edson; Campos, Alexandre Rainha; Sousa, João M.; Nunes, Rita G.; Gonçalves-Ferreira, António; Campos, Jorge

doi:10.1111/ner.12289

Cited by 15 publications

(10 citation statements)

References 70 publications

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“…However, this connectivity pattern is varied in some previous studies (Baliki et al, ; Lucas‐Neto et al, ). Baliki et al used diffusion tractography to subdivide the right NAc into lateral‐rostral (putative core, pcore) and medial‐caudal (putative shell, pshell) subdivisions in healthy humans and demonstrated a preferential structural connectivity of core with BG and OFC, and shell with AMYG.…”

Section: Discussionmentioning

confidence: 88%

“…Previous reports examined the in vivo segmentation of the healthy human NAc using probabilistic tractography (Baliki et al, ; Lucas‐Neto et al, ). To our knowledge, we are the first to parcellate the nucleus accumbens of individual mTLE patients into core and shell portions using DTI probabilistic tractography in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…We evaluated the probabilistic connections between each group‐averaged NAc subdivision and 16 predefined target regions in the standard space using the PROBTRACKX for every subject. In accordance with previous tract tracing (Baliki et al, ; Lucas‐Neto et al, ) and anatomical studies (Basar et al, ; Haber, ; Haber and Knutson, ), sixteen target regions in the same hemisphere were chosen (Figure b). These target regions were extracted from the Harvard–Juliet atlas and included the amygdala (AMY), caudate (CAU), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), orbital frontal cortex (OFC), frontal pole (FP), hippocampus (HIP), insula (INS), globus pallidus (GP), paracingulate gyrus (PCG), anterior‐parahippocampal gyrus (Ante‐PHG), posterior‐parahippocampal gyrus (Post‐PHG), putamen (PUT), subcallosal cortex (SCC), thalamus (THA), and temporal pole (TP).…”

Section: Methodsmentioning

confidence: 99%

“…We evaluated the probabilistic connections between each groupaveraged NAc subdivision and 16 predefined target regions in the standard space using the PROBTRACKX for every subject. In accordance with previous tract tracing ( Baliki et al, 2013;Lucas-Neto et al, 2015) and anatomical studies (Basar et al, 2010;Haber, 2011;Haber and Knutson, 2010) The probability of structural connectivity from the seed to each target was defined as the number of fibers passing through the target from the seed divided by the number of fibers that were sampled in the seed (5000 3 number of voxels in the seed). Connection probabilities were then divided by the size of the target region to produce normalized connection probabilities adjusted for the volume of the target region.…”

Section: Anatomical Connectivity Patterns Of the Nac Subregionsmentioning

confidence: 99%

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Connectivity‐based parcellation of the nucleus accumbens into core and shell portions for stereotactic target localization and alterations in each NAc subdivision in mTLE patients

Zhao

Yang

Wang

et al. 2017

Human Brain Mapping

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The nucleus accumbens (NAc), an important target of deep brain stimulation for some neuropsychiatric disorders, is thought to be involved in epileptogenesis, especially the shell portion. However, little is known about the exact parcellation within the NAc, and its structural abnormalities or connections alterations of each NAc subdivision in temporal lobe epilepsy (TLE) patients. Here, we used diffusion probabilistic tractography to subdivide the NAc into core and shell portions in individual TLE patients to guide stereotactic localization of NAc shell. The structural and connection abnormalities in each NAc subdivision in the groups were then estimated. We successfully segmented the NAc in 24 of 25 controls, 14 of 16 left TLE patients, and 14 of 18 right TLE patients. Both left and right TLE patients exhibited significantly decreased fractional anisotropy (FA) and increased radial diffusivity (RD) in the shell, while there was no significant alteration in the core. Moreover, relatively distinct structural connectivity of each NAc subdivision was demonstrated. More extensive connection abnormalities were detected in the NAc shell in TLE patients. Our results indicate that neuronal degeneration and damage caused by seizure mainly exists in NAc shell and provide anatomical evidence to support the role of NAc shell in epileptogenesis. Remarkably, those NAc shell tracts with increased connectivities in TLE patients were found decreased in FA, which indicates disruption of fiber integrity. This finding suggests the regeneration of aberrant connections, a compensatory and repair process ascribed to recurrent seizures that constitutes part of the characteristic changes in the epileptic network.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Anatomical Connectivity Patterns Of the Nac Subregionsmentioning

confidence: 99%

See 2 more Smart Citations

Connectivity‐based parcellation of the nucleus accumbens into core and shell portions for stereotactic target localization and alterations in each NAc subdivision in mTLE patients

Zhao

Yang

Wang

et al. 2017

Human Brain Mapping

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“…Indeed, in nonhuman primates, the nucleus accumbens shell and core subregions are organized in a series of parallel circuits linked in an ascending spiral to the dorsal striatum in a manner that could account for the transition from goal-directed to habitual behaviors during the development of addiction (Renteria et al, 2016). Whether these bidirectional nucleus accumbens circuits are relevant to human addiction will require further evaluation and the development of imaging methods with higher resolution and greater detection capabilities for microstructure and neurochemistry (Lucas-Neto et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Perspectives on fronto-fugal circuitry from human imaging of alcohol use disorders

2017

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Descriptions of the cognitive functions affected by alcohol use disorders (AUD) often highlight dysfunction of executive processes such attention, inhibitory control, working memory, and cognitive flexibility. Such complex cognitive functions have historically been ascribed to the prefrontal cortex. AUD, however, disrupts extensive areas of the brain. Structural and functional MRI studies suggest a central role for degradation of circuitry originating in the prefrontal cortex including nodes in widespread brain regions. This review features fronto-fugal circuits affected by AUD including frontocerebellar, frontolimbic, and frontostriatal networks and their relations to the salient, enduring, and debilitating cognitive and motor deficits reported in AUD.

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Implications of Developmental 17‐OHPC Exposure on the Mesocorticolimbic Serotonergic and Dopaminergic Pathways and Adolescent Mood–Related Behavior in Rats

Graney,

Sarno,

Miller

et al. 2024

Developmental Psychobiology

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The synthetic progestin, 17‐α‐hydroxyprogesterone caproate (17‐OHPC), is administered to pregnant individuals at risk for recurrent preterm birth during a critical period of fetal mesocorticolimbic serotonergic and dopaminergic pathway development. These pathways play an important role in regulating cognitive behaviors later in life. Despite this, there has been very little research regarding the potential long‐term effects of 17‐OHPC on the behavioral and neural development of exposed children. In rodents, developmental exposure to 17‐OHPC disrupts serotonergic and dopaminergic innervation of the medial prefrontal cortex and impairs decision‐making in complex cognitive tasks in adulthood. The present study tested the hypothesis that developmental exposure to 17‐OHPC similarly disrupts the development of serotonergic and dopaminergic pathways within limbic targets and subsequent mood‐related behaviors. Developmental 17‐OHPC exposure significantly increased the density of serotonin transporter–IR fibers in CA1, CA2/3, and the suprapyramidal blade of dentate gyrus in hippocampus and significantly reduced the density of TH‐IR fibers within the nucleus accumbens shell in males but had no effect in females during adolescence. Irregular microglia activational phenotype and number were also observed in the hippocampus of 17‐OHPC‐exposed males. Developmental 17‐OHPC reduced the latency to immobility in males in the forced swim test but did not affect sucrose consumption in a sucrose preference test. These findings suggest that 17‐OHPC exerts sex‐specific effects on the development of mesocorticolimbic pathways and mood‐related behavior in adolescence and highlight the need to investigate effects in adolescent children.

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Advanced MR Imaging of the Human Nucleus Accumbens—Additional Guiding Tool for Deep Brain Stimulation

Cited by 15 publications

References 70 publications

Connectivity‐based parcellation of the nucleus accumbens into core and shell portions for stereotactic target localization and alterations in each NAc subdivision in mTLE patients

Connectivity‐based parcellation of the nucleus accumbens into core and shell portions for stereotactic target localization and alterations in each NAc subdivision in mTLE patients

Perspectives on fronto-fugal circuitry from human imaging of alcohol use disorders

Implications of Developmental 17‐OHPC Exposure on the Mesocorticolimbic Serotonergic and Dopaminergic Pathways and Adolescent Mood–Related Behavior in Rats

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