Advanced Method for Evaluation of Gastric Cancer Risk By Serum Markers: Determination of True Low‐Risk Subjects for Gastric Neoplasm

Boda, Tomoyuki; Ito, Masanori; Yoshihara, Masaharu; Kitamura, Yoko; Matsuo, Taiji; Oka, Shiro; Tanaka, Shinji; Chayama, Kazuaki

doi:10.1111/hel.12101

Cited by 43 publications

(57 citation statements)

References 27 publications

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“…On the other hand, Boda et al reported that more than 10% of gastric cancer patients were classified into group A, suggesting that some patients with gastric cancer risk may be included in group A [12]. Recently, Itoh et al also reported the aberration of high-risk subjects in group A by using radiologic findings [18].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the patients in Hiroshima University Hospital, we chose the patients from the database used in the previous study by Boda et al [12]. These 183 gastric cancer patients (136 men; mean age, 66.4 years) with H. pylori-positive results or with CAG were used as controls.…”

Section: Group Bcd Gastric Cancer Patientsmentioning

confidence: 99%

“…Group A includes subjects with neither H. pylori infection nor CAG by testing; however, group A contains H. pylori-infected subjects. Boda et al reported that approximately 10% of patients with gastric tumors (cancer or adenoma) belong to group A [12]. The cancer risk of these patients may be underappreciated using the current criteria of the ABC classification system.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study

et al. 2016

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Background and aim The serological risk prediction system combines the pepsinogen test and anti-Helicobacter pylori (H. pylori) antibody determination. In this system, chronic atrophic gastritis (CAG) is diagnosed using the pepsinogen test. Patients who are H. pylori negative and pepsinogen negative are classified into group A, are assumed to be H. pylori uninfected, and are at an extremely low risk for gastric cancer. However, gastric cancers are detected in this group. The aim of this study is to clarify the clinicopathological status of group A patients with gastric cancer. Methods A total of 109 gastric cancer patients classified as group A were enrolled in a multicenter study. Group A patients were divided into two subgroups: group AN (H. pylori uninfected) and group AP (H. pylori infected). They were compared to 183 H. pylori-infected gastric cancer patients who were not in group A. 123Gastric Cancer (2017( ) 20:764-771 DOI 10.1007 Results Of the 109 patients, only 7 were classified as group AN; the other 102 were classified as group AP. The clinicopathological features of group AP included older age, predominantly differentiated type cancer, endoscopically visualized CAG, and pepsinogen (PG) I/II ratio lower than that of group AN. In group AN, the depressed type was dominant, and the PG I/II ratio was higher than in those gastric cancer patients who were infected with H. pylori. Conclusion Patients in group AP had CAG, and their gastric cancers were similar to those of H. pylori-eradicated patients. Concerning the recent ABC classification system, advanced decision criteria should be proposed to decrease the false-negative evaluation of gastric cancer risk.

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Section: Discussionmentioning

confidence: 99%

Section: Group Bcd Gastric Cancer Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study

et al. 2016

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“…In most cases, a positive result for serum H. pylori antibody indicates current H. pylori infection. Thus, a gastric cancer screening method using serum anti- H. pylori antibody and PG tests has been applied in some health check-up settings in Japan for screening high risk subjects of gastric cancer, and the method is called as the “ABC method” [6,7,8,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of <b><i>Helicobacter pylori</i></b> Infection in Subjects with Seemingly Normal Pepsinogen Levels

Kishikawa¹,

Kimura²,

Ito³

et al. 2017

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Backgrounds/Aims: In the ABC method, which is a method for risk stratification of gastric cancer using serum anti-Helicobacter pylori antibody and pepsinogen (PG) test, subjects with normal PG and seronegative for H. pylori are named as “Group A” and are regarded as having a low risk of gastric cancer. These “Group A” subjects include unintentionally eradicated cases at relatively high risk, and this study aimed to identify these subjects. Methods: Of the 109 subjects, 76 were classified as uninfected Group A subjects with negative histologic H. pylori infection and no histologic and endoscopic atrophy, and 33 subjects were classified serologically as Group A after successful eradication, which are serologically equal to the unintendedly eradicated cases in Group A. The usefulness of measuring PG levels to detect post-eradication cases was validated by using a receiver operating characteristic (ROC) curve analysis. Results: The area under the ROC curve for PGI level was 0.736 ± 0.06 (p < 0.01; cutoff value, 37.0 ng/mL; sensitivity, 77.6%; specificity, 72.7%), and that for the PGI/II ratio was 0.660 ± 0.06 (p < 0.01; cutoff value, 5.1; sensitivity, 84.2%; specificity, 43.4%). Conclusion: PGI levels of ≤37 ng/mL and PGI/II ratios of ≤5.1 effectively identified unintendedly eradicated cases in Group A.

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“…The main reservoir of H. pylori in humans is the digestive tract, but the bacterium has also been found in biopsy samples, dental plaque, saliva and feces [7]. In recent years, a decrease in the incidence of H. pylori infection in both children and adults has been observed in many countries [8][9][10]. The objective of this study was to estimate the prevalence of H. pylori infection and NHPH infection in symptomatic children over a 13-year study period, and to analyze the resistance rates of H. pylori strains to antibiotics.…”

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confidence: 99%

The Prevalence of Helicobacter pylori Infection in Symptomatic Children: A 13-Year Observational Study in the Lower Silesian Region

Biernat¹,

Iwańczak²,

Bińkowska³

et al. 2016

Adv Clin Exp Med

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Advanced Method for Evaluation of Gastric Cancer Risk By Serum Markers: Determination of True Low‐Risk Subjects for Gastric Neoplasm

Abstract: Group A included a certain number of patients with atrophic gastritis who were potentially at risk of gastric neoplasm development. Although evaluation of corpus atrophy is necessary for the identification of these patients, the discriminant function may be useful.

Cited by 43 publications

References 27 publications

Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study

Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of <b><i>Helicobacter pylori</i></b> Infection in Subjects with Seemingly Normal Pepsinogen Levels

The Prevalence of Helicobacter pylori Infection in Symptomatic Children: A 13-Year Observational Study in the Lower Silesian Region

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