Advanced melatonin onset relative to sleep in women with unmedicated major depressive disorder

Coleman, Michelle Y.; McGlashan, Elise M.; Vidafar, Parisa; Phillips, Andrew J. K.; Cain, Sean W.

doi:10.1080/07420528.2019.1644652

Cited by 14 publications

(8 citation statements)

References 57 publications

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“…The term for this treatment is bright light therapy. Arendt and Middleton, a team of scientists working in the Antarctic circle, utilized bright light therapy to diminish psychological symptoms of disrupted rhythms such as depression, fatigue, and decreased libido [56]. The therapy shows much promise; however, more investigation is needed to prove its effectiveness in a variety of clinical scenarios.…”

Section: Discussionmentioning

confidence: 99%

Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin

McBride²,

2021

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Sleep is an essential component of overall human health but is so tightly regulated that when disrupted can cause or worsen certain ailments. An important part of this process is the presence of the well-known hormone, melatonin. This compound assists in the governing of sleep and circadian rhythms. Previous studies have postulated that dysregulation of melatonin rhythms is the driving force behind sleep and circadian disorders. A computer-aided search spanning the years of 2015–2020 using the search terms melatonin, circadian rhythm, disorder yielded 52 full text articles that were analyzed. We explored the mechanisms behind melatonin dysregulation and how it affects various disorders. Additionally, we examined associated therapeutic treatments including bright light therapy (BLT) and exogenous forms of melatonin. We found that over the past 5 years, melatonin has not been widely investigated in clinical studies thus there remains large gaps in its potential utilization as a therapy.

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Section: Discussionmentioning

confidence: 99%

Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin

McBride²,

2021

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“…Likewise, it was confirmed that SNP pill has a synergistic effect when combined with fluoxetine to improve sucrose preference, spontaneous activity, and modulate central and peripheral 5‐HT levels in rats 33 . Besides, a previous study indicated that SNP might prolong slow‐wave sleep 2 (SWS2) and REM sleep, producing sedative‐like effects and regulating the sleep‐wake cycle 34 . In addition, SNP exerted a significant antidepressant effect by affecting mineral absorption, restoring differentially expressed proteins and leading to steroid hormone biosynthesis and metabolism 9…”

Section: Discussionmentioning

confidence: 82%

“…33 Besides, a previous study indicated that SNP might prolong slow-wave sleep 2 (SWS2) and REM sleep, producing sedative-like effects and regulating the sleepwake cycle. 34 In addition, SNP exerted a significant antidepressant effect by affecting mineral absorption, restoring differentially expressed proteins and leading to steroid hormone biosynthesis and metabolism. 9 Second, the changes in sleep in individuals with MDD along with therapy were explored.…”

Section: Discussionmentioning

confidence: 99%

Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double‐blind, placebo‐controlled trial

Zhang

et al. 2022

Journal of Pineal Research

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Circadian rhythm disorder is a significant risk factor for mental diseases, and the recovery of circadian rhythm function has gradually become a signal of effective antidepressant therapy. Sini powder (SNP) is a classical, traditional Chinese formula for depression treatment. However, few clinical reports have been recorded. This randomized, double-blinded, controlled trial (ChiCTR1900022700) aimed to explore the efficacy of SNP on depression via regulating circadian rhythm. In total, 36 patients with major depressive disorder (MDD) were enrolled for 4-weeks medication and 6-weeks follow-up. HAMD-24 score and circadian rhythm index, including dim light melatonin onset (DLMO) and phase angle difference (PAD), were included in the assessment. DLMO and PAD were statistically significant in the SNP group after 4 weeks of treatment (p < .05) and with greater improvement in DLMO (p = .03). In addition, DLMO and the HAMD-24 score showed a positive correlation (p < .05); the HAMD-24 score degree decreased significantly over time (p < .001). Similarly, interaction effects were shown significantly between group and time (p = .049). The duration of SNP supplementation was relatively short, and the sample size was relatively small. SNP granules combined with paroxetine tablets have definite efficacy in improving the circadian rhythms of MDD patients, reflecting the therapeutic advantages of traditional Chinese medicine as antidepressants.

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“…Patients with depression have been found to have weakened circadian rhythms (blunted amplitude) 4 an effect that is reversed in recovery 5,6 . Greater disruption of circadian timing has been associated with poorer mood outcomes 7,8 . The severity of mood symptoms and the duration of depressive episodes are greater in those who experience circadian rhythm disturbance 8,9 and the presence of circadian disturbance in depression is predictive of a greater risk for recurrence 10,11 .…”

Section: Discussionmentioning

confidence: 99%

Low daytime light and bright night-time light are associated with psychiatric disorders: an objective light study in >85,000 UK Biobank participants

Burns

Windred

Rutter

et al. 2022

Preprint

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Circadian rhythm disturbance is a common feature of psychiatric disorders. Light is the primary input to the circadian clock, with daytime light exposure strengthening rhythms and nighttime light exposure weakening rhythms. However, the independent effects of day and night light exposure on psychiatric outcomes have not been well characterized. In this study, we performed the largest to-date cross-sectional analysis of objectively measured day and night light exposure and examined their relationship with psychiatric disorders. UK Biobank cohort participants aged 37-73 years were recruited into the UK Biobank general cohort population. In a subset of participants (n=86,772; 43% male), light and physical activity patterns were monitored for ~7 days. Using regression models adjusted for age, sex, ethnicity, photoperiod (day length), employment, and physical activity, we examined the independent associations of day and night-time light with psychiatric disorders and measures of symptom severity. We found that greater night light exposure was associated with greater odds of major depressive disorder (MDD), generalized anxiety disorder (GAD), bipolar disorder, post-traumatic stress disorder (PTSD), self-harm behavior and psychotic experiences. Conversely, greater daytime light exposure was associated with lower odds of MDD, PTSD, self-harm behavior and psychotic experiences. There was no significant association of day light exposure with GAD or bipolar disorder. Our findings demonstrate that low day light and bright night light exposure are associated with a wide range of psychiatric outcomes. Avoiding light at night and seeking light during the day may be a simple and effective, non-pharmacological means of broadly improving mental health.

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Advanced melatonin onset relative to sleep in women with unmedicated major depressive disorder

Cited by 14 publications

References 57 publications

Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin

Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin

Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double‐blind, placebo‐controlled trial

Low daytime light and bright night-time light are associated with psychiatric disorders: an objective light study in >85,000 UK Biobank participants

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