Advanced Maternal Age and Its Association With Cardiovascular Disease in Later Life

Wolfson, Carrie; Gemmill, Alison; Strobino, Donna M.

doi:10.1016/j.whi.2021.12.007

Cited by 5 publications

(12 citation statements)

References 46 publications

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Section: Discussioncontrasting

confidence: 99%

“…The results of the current analysis of no conclusive association between maternal ALB and CVD mortality are somewhat in contrast to one of the few previous studies that examined the relationship between age at birth and future risk of incident CVD events 8 . In their study of 70,649 women enrolled in the NHS-II, Wolfson et al 8 reported that advanced maternal age at first birth was not associated with incident CVD but advanced maternal age at any birth was associated with a 15% reduced risk for incident fatal or nonfatal CVD after adjustment for demographic, fertility, and health characteristics. Despite the current NHANES cohort comprising of a large ethnically diverse sample and having more CVD events than those reported among the predominantly White registered nurses from NHS-II (6% vs 1%), several other methodological differences may explain some of the discrepancies in results between these two studies.…”

Section: Discussioncontrasting

confidence: 99%

“…Given these trends, it is important to understand the health benefits or consequences of childbearing at advanced maternal ages (≥35 years), 3-5 particularly cardiovascular disease (CVD) mortality. However, few reports examine this association 6-8 …”

mentioning

confidence: 99%

“…However, few reports examine this association. [6][7][8] Maternal age at last birth (ALB) in many ways shapes the rest of the life cycle of women. 9 Therefore, it is imperative to understand the unique roles that ALB play in future cardiovascular health.…”

mentioning

confidence: 99%

“…A recent report from the Nurses' Health Study II (NHS-II) observed that after accounting for demographic, health and fertility factors, women 35 years and older at births had a 15% lower risk of CVD compared with women who completed childbearing before age 35 years. 8 As the NHS-II cohort is predominantly White, it is unclear whether this association also exists in Black women, who are at higher risk for obstetric complications with advancing age. 10,11 In addition, it is not known to what extent association is due to prepregnancy factors that are linked to both older maternal age, as well as CVD risk or postpregnancy factors that may represent the impact of pregnancy upon maternal health.…”

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confidence: 99%

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Maternal age at birth of last child and cardiovascular disease mortality later in life among a national cohort of postmenopausal women from the United States

et al. 2023

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Objective: Maternal age at last birth (ALB) of child is increasing in the United States, and it has been reported to influence future chronic diseases. However, the relationship of ALB and cardiovascular disease (CVD) events later in life has not been widely studied. We evaluated the association of ALB with CVD mortality.Methods: Data were from 7,971 parous postmenopausal women older than 45 years who participated in the US National Health and Nutritional Examination Survey from 1999 to 2018 and had mortality follow-up data through to December 31, 2019. ALB was self-reported, whereas CVD mortality was assessed using International Classification of Diseases codes. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).Results: The mean age of participants was 63 ± 9.8 years, with 9.5% being non-Hispanic Black, 9.7% being Hispanic women, and 21% reporting ALB ≥35 years. During a median follow-up of 8.1 years, 443 participants died from CVD. In age-adjusted models, CVD mortality was elevated for women with ALB of <25 years (HR, 1.68; 95% CI, 1.23-2.29) and ALB of ≥35 years (HR, 1.37; 95% CI, 1.00-1.88). However, after additional adjustment for race and ethnicity, foreign born, education, marital status, poverty income ratio, parity, smoking status, age at menarche, oral contraceptive pills use and family history of myocardial infarction, these estimates were attenuated resulting in no association between ALB and CVD mortality.Conclusions: In this study of nationally representative sample of postmenopausal women, there was no conclusive association between maternal ALB and CVD mortality later in life.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Maternal age at birth of last child and cardiovascular disease mortality later in life among a national cohort of postmenopausal women from the United States

et al. 2023

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Association between late maternal age and age-related endophenotypes in the Long Life Family Study

Barral

Andersen

Perls

et al. 2022

Neuroscience Letters

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The association of female reproductive factors with history of cardiovascular disease: a large cross-sectional study

Chen,

Wu,

Pan

et al. 2024

BMC Public Health

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Background This study aimed to explore the association of female reproductive factors (age at first birth (AFB), age at last birth (ALB), number of pregnancies, and live births) with history of cardiovascular disease (CVD). Methods A total of 15,715 women aged 20 years or over from the National Health and Nutrition Examination Surveys from 1999 to 2018 were included in our analysis. Weighted multivariable logistic regression analysis and restricted cubic spline (RCS) model were used to evaluate the association of AFB and ALB with history of CVD in women. Additionally, the relationship between the number of pregnancies, and live births and history of CVD was also explored. Results After adjusting for potential confounding factors, the RCS plot showed a U-curve relationship between AFB, ALB and history of CVD. Among them, AFB was associated with congestive heart failure (CHF), heart attack, and stroke in a U-shaped curve. Additionally, this U-shaped correlation also exists between ALB and CHF and stroke. However, the number of pregnancies and live births was liner positive associated with history of CVD, including coronary heart disease, CHF, angina pectoris, heart attack, and stroke. Conclusions Women with younger or later AFB and ALB have higher odds of CVD in later life. Further study is warranted to verify the underlying mechanisms of this association.

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Advanced Maternal Age and Its Association With Cardiovascular Disease in Later Life

Cited by 5 publications

References 46 publications

Maternal age at birth of last child and cardiovascular disease mortality later in life among a national cohort of postmenopausal women from the United States

Maternal age at birth of last child and cardiovascular disease mortality later in life among a national cohort of postmenopausal women from the United States

Association between late maternal age and age-related endophenotypes in the Long Life Family Study

The association of female reproductive factors with history of cardiovascular disease: a large cross-sectional study

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