Advanced Materials Based on Nanosized Hydroxyapatite

Rial, Ramón; González-Durruthy, Michael; Liu, Zhen; Ruso, Juan M.

doi:10.3390/molecules26113190

Cited by 34 publications

(26 citation statements)

References 163 publications

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“…Since both TEMPO and hydroxyapatites can be used as catalysts, it is possible that the combined material will also have this application. Nitroxide radicals and compounds modified by them are mainly used in oxidation reactions [ 68 , 69 ], while hydroxyapatites can be employed in numerous processes, e.g., racemization, biogasoline synthesis and reactions requiring transition metal catalysts [ 70 ]. The issue of whether the HA/TEMPO composites will have additional benefits as catalysts requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Composites Containing Nanohydroxyapatites and a Stable TEMPO Radical: Preparation and Characterization Using Spectrophotometry, EPR and 1H MAS NMR

et al. 2022

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Hydroxyapatite is the main constituent of mammalian hard tissues. Basic applications of synthetic hydroxyapatites include bone and dental implantology and drug delivery systems. The study of hydroxyapatite surface properties could give greater insight into the processes of bone mineralization and degradation. Nitroxide radicals are stable radicals that exhibit anticancer and antioxidative properties and are often used as spin probes to study the dynamics of complex biological systems. In this work, we attempted to adsorb the stable 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) on two hydroxyapatites (HAs) differing in specific surface area and the degree of hydration. The adsorption was carried out from cyclohexane, 1-chlorobutane and water. The solutions after adsorption were studied spectrophotometrically, while the obtained composites were characterized via NMR and EPR spectroscopy. The results show that it is possible to reproducibly obtain fairly stable composites, where the main factors influencing the adsorbed amount of the radical are solvent polarity and specific surface area of hydroxyapatite. The Langmuir isotherm was determined to be the most suitable adsorption model. The analysis of EPR and NMR spectra allowed us to determine the distribution of the TEMPO molecules on the hydroxyapatite surface, as well as a probable adsorption mechanism. The HA/TEMPO composites could potentially be used to study certain properties of hydroxyapatite surfaces with EPR spectroscopy. They could also be used as fillers after hard tissue surgery, as well as metal-free MRI contrasts.

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Section: Discussionmentioning

confidence: 99%

Composites Containing Nanohydroxyapatites and a Stable TEMPO Radical: Preparation and Characterization Using Spectrophotometry, EPR and 1H MAS NMR

et al. 2022

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“…Importantly, hydroxyapatite provides also a good osteointegration so it allows formation of the direct functional and structural connection between the tissue and the biomaterial modified with this inorganic compound [ 9 , 10 , 11 ]. Due to these features HAp is often used currently for preparation of various biomaterials [ 12 , 13 ]. For example, a growing interest is currently observed for application of hydroxyapatite in preparation of coatings for implants.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Obtained via the Wet Precipitation Method and PVP/PVA Matrix as Components of Polymer-Ceramic Composites for Biomedical Applications

et al. 2021

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The aspect of drug delivery is significant in many biomedical subareas including tissue engineering. Many studies are being performed to develop composites with application potential for bone tissue regeneration which at the same provide adequate conditions for osteointegration and deliver the active substance conducive to the healing process. Hydroxyapatite shows a great potential in this field due to its osteoinductive and osteoconductive properties. In the paper, hydroxyapatite synthesis via the wet precipitation method and its further use as a ceramic phase of polymer–ceramic composites based on PVP/PVA have been presented. Firstly, the sedimentation rate of hydroxyapatite in PVP solutions has been determined, which allowed us to select a 15% PVP solution (sedimentation rate was 0.0292 mm/min) as adequate for preparation of homogenous reaction mixture treated subsequently with UV radiation. Both FT-IR spectroscopy and EDS analysis allowed us to confirm the presence of both polymer and ceramic phase in composites. Materials containing hydroxyapatite showed corrugated and well-developed surface. Composites exhibited swelling properties (hydroxyapatite reduced this property by 25%) in simulated physiological fluids, which make them useful in drug delivery (swelling proceeds parallel to the drug release). The short synthesis time, possibility of preparation of composites with desired shapes and sizes and determined physicochemical properties make the composites very promising for biomedical purposes.

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“…The proposed biomaterial must be able to interact with the surrounding tissue, and the patient’s immune response must be minimized. Furthermore, the scaffold should provide adequate mechanical strength to the bone defect site and efficiently encapsulate and control the release of drugs or proteins [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering

Chang

Wang

Liu

et al. 2022

Gels

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Bone defects, as one of the most urgent problems in the orthopedic clinic, have attracted much attention from the biomedical community and society. Hydrogels have been widely used in the biomedical field for tissue engineering research because of their excellent hydrophilicity, biocompatibility, and degradability. Stimulus-responsive hydrogels, as a new type of smart biomaterial, have more advantages in sensing external physical (light, temperature, pressure, electric field, magnetic field, etc.), chemical (pH, redox reaction, ions, etc.), biochemical (glucose, enzymes, etc.) and other different stimuli. They can respond to stimuli such as the characteristics of the 3D shape and solid–liquid phase state, and exhibit special properties (injection ability, self-repair, shape memory, etc.), thus becoming an ideal material to provide cell adhesion, proliferation, and differentiation, and achieve precise bone defect repair. This review is focused on the classification, design concepts, and research progress of stimulus-responsive hydrogels based on different types of external environmental stimuli, aiming at introducing new ideas and methods for repairing complex bone defects.

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Advanced Materials Based on Nanosized Hydroxyapatite

Cited by 34 publications

References 163 publications

Composites Containing Nanohydroxyapatites and a Stable TEMPO Radical: Preparation and Characterization Using Spectrophotometry, EPR and 1H MAS NMR

Composites Containing Nanohydroxyapatites and a Stable TEMPO Radical: Preparation and Characterization Using Spectrophotometry, EPR and 1H MAS NMR

Hydroxyapatite Obtained via the Wet Precipitation Method and PVP/PVA Matrix as Components of Polymer-Ceramic Composites for Biomedical Applications

Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering

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