Advanced material technologies for space and terrestrial medicine

Chua, Corrine Ying Xuan; Jimenez, Miguel; Mozneb, Maedeh; Traverso, Giovanni; Lugo, Ray; Sharma, Arun; Svendsen, Clive N.; Wagner, William R.; Langer, Robert; Grattoni, Alessandro

doi:10.1038/s41578-024-00691-0

Nat Rev Mater

2024

DOI: 10.1038/s41578-024-00691-0

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Advanced material technologies for space and terrestrial medicine

Corrine Ying Xuan Chua,

Miguel Jimenez,

Maedeh Mozneb

et al.

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Cited by 2 publications

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Light-based 3D bioprinting techniques for illuminating the advances of vascular tissue engineering

Li,

Pan

et al. 2024

Materials Today Bio

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Light-based 3D bioprinting techniques for illuminating the advances of vascular tissue engineering

Li,

Pan

et al. 2024

Materials Today Bio

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Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight

Mozneb,

Arzt,

Mesci

et al. 2024

npj Microgravity

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Low Earth Orbit (LEO) has emerged as a unique environment for evaluating altered stem cell properties in microgravity. LEO has become increasingly accessible for research and development due to progress in private spaceflight. Axiom Mission 2 (Ax-2) was launched as the second all-private astronaut mission to the International Space Station (ISS). Frozen human induced pluripotent stem cells (hiPSCs) expressing green fluorescent protein (GFP) under the SOX2 promoter, as well as fibroblasts differentiated from SOX2-GFP hiPSCs, were sent to the ISS. Astronauts then thawed and seeded both cell types into commercially available 96-well plates, which provided surface tension that reduced fluid movement out of individual wells and showed that hiPSCs or hiPSC-derived fibroblasts could survive either in suspension or attached to a Matrigel substrate. Furthermore, both cell types could be transfected with red fluorescent protein (RFP)-expressing plasmid. We demonstrate that hiPSCs and hiPSC-fibroblasts can be thawed in microgravity in off-the-shelf, commercially-available cell culture hardware, can associate into 3D spheroids or grow adherently in Matrigel, and can be transfected with DNA. This lays the groundwork for future biomanufacturing experiments in space.

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Advanced material technologies for space and terrestrial medicine

Cited by 2 publications

References 161 publications

Light-based 3D bioprinting techniques for illuminating the advances of vascular tissue engineering

Light-based 3D bioprinting techniques for illuminating the advances of vascular tissue engineering

Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight

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