Advanced lung cancer inflammation index predicts overall survival of hepatocellular carcinoma after hepatectomy

Abstract

AimLimited data are available regarding ALI’s clinical relevance and prognostic value in patients with hepatocellular carcinoma (HCC) after hepatectomy.Materials and methodsHCC patients who received hepatectomy at the Meizhou People’s Hospital from May 2011 to February 2022 were enrolled in the study cohort. The ALI was calculated as follows: ALI = BMI (kg/m2) × ALB (g/dL)/(absolute neutrophil count/absolute lymphocyte count). The primary outcome was overall survival (OS). The secondary outcome was cancer-specific survival (CSS). Univariate and multivariate Cox regression analyses were performed, followed by nomogram construction and decision curve analysis (DCA).Results425 HCC patients were enrolled for analyses. Lower preoperative ALI was significantly correlated with incomplete tumor capsule and advanced tumor stage. Lower preoperative ALI was an adverse independent prognostic factor for OS (HR: 1.512, 95% CI: 1.122-2.039, P 0.007) and CSS (HR: 1.754, 95% CI: 1.262-2.438, P <0.001) in HCC patients. The nomogram plot was built based on three (including age, TNM stage, and ALI) and two (including TNM stage and ALI) independent prognostic factors for OS and CSS, respectively. Further analyses indicated that the nomogram had better predictive value and some net benefit than the traditional TNM stage alone, especially in long-term OS.ConclusionsOur study further indicated that ALI could be a prognostic marker for OS and CSS in HCC patients after hepatectomy, especially in long-term OS.

Predictive Value of the Advanced Lung Cancer Inflammation Index for the Postoperative Complications of Lung Resections in Patients with Bronchiectasis: A Retrospective Study Short Title : Study on the Correlation between the Advanced Lung Cancer Inflammation Index and Patients with Bronchiectasis

“…This index can simultaneously re ect the nutritional and in ammatory status of patients [14]. he correlation between a lower ALI and poorer prognosis has been established in various cancers and in ammatory diseases [15][16][17][18][19][20][21]. Nonetheless, research on the clinical signi cance of the ALI in bronchiectasis patients remains limited.…”

“…The Advanced Lung Cancer In ammation Index (ALI), which integrates BMI, the serum ALB concentration, and the neutrophil-to-lymphocyte ratio (NLR), was initially developed by Jafri et al to evaluate the prognosis of patients with metastatic non-small cell lung cancer (NSCLC) [14]. Subsequent studies have demonstrated that the ALI is effective in predicting the outcomes of various cancers, including hepatocellular carcinoma, esophageal squamous cell carcinoma, gastric cancer, colorectal cancer, and even benign conditions such as hypertension, acute coronary syndrome, and diabetes mellitus [15][16][17][18][19][20][21]. Additionally, the ALI has been utilized as a predictor of postoperative complications in colon cancer patients [22].…”