Advanced Lung Cancer Inflammation Index Predicts Outcomes of Patients with Pathological Stage IA Lung Adenocarcinoma Following Surgical Resection

Abstract

Purpose: The correlation of advanced cancer with inflammation and/or nutrition factors is well known. Recently, the advanced lung cancer inflammation index (ALI) was developed as a new prognostic tool for patients with advanced lung cancer. In this study, we examined whether ALI results are correlated with prognosis of patients with early stage lung adenocarcinoma who undergo lung resection. Methods: From January 2009 to December 2014, 544 patients underwent lung resection due to primary lung cancer at Dokkyo Medical University Hospital, of whom 166 with pathological stage IA lung adenocarcinoma were retrospectively investigated in this study. ALI was calculated as follows: Body Mass Index (BMI; kg/m 2 ) × albumin (g/dL)/neutrophil- to-lymphocyte ratio (NLR). Results: Multivariate analysis revealed that gender, red cell distribution width (RDW), NLR, and ALI were parameters significantly correlated with overall survival (OS). Patients with an ALI value less than 22.2 had an inferior 5-year OS rate as compared to those with a value of 22.2 or higher (p <0.001) as well as an inferior 5-year recurrence-free survival (RFS) rate (p <0.001). Conclusion: Low ALI was correlated with poor prognosis in patients with stage IA lung adenocarcinoma. Those with an ALI value less than 22.2 should be carefully followed regardless of cancer stage.

Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis

“…Kobayashi et al examined the prognostic value of the ALI in lung adenocarcinoma patients and concluded that the ALI was an independent predictor of OS (HR = 7.55, 95% CI = 3.03-18.8) and had a better prognostic value than the NLR (HR = 3.91, 95% CI = 1. 36-11.26) and GPS (HR = 1.24, 95% CI = 0.32-4.77) [33]. Tomita et al revealed that the preoperative ALI and CRP levels were significant predictors of OS in patients with NSCLC and that the ALI (HR = 0.436, 95% CI = 0.278-0.679) was superior to the CRP level (HR = 0.631, 95% CI = 0.403-0.993) as a prognostic index [56].…”

“…1. Ultimately, nine studies met our selection criteria; after excluding duplicated studies and reviewing the full texts of the manuscripts [25,[29][30][31][32][33][34][35][36], a total of 1736 cases were included. With respect to prognostic outcomes, nine studies reported OS, two studies reported progression-free survival, and one study reported disease-free survival.…”

Impact of Age on Inflammation-Based Scores among Patients Diagnosed with Stage III Non-Small Cell Lung Cancer

“…The PLR is determined by the platelet count divided by the lymphocyte count. Finally, the GPS combines an inflammatory parameter (CRP) and a nutritional factor (albumin): patients are assigned 1 point if they have a CRP level >10 mg/L or hypoalbuminemia (<3.5 g/dL), and they are finally classified into groups with 0, 1, or 2 points [20].…”

Using Systematized Nomenclature of Medicine clinical term codes to assign histological findings for prostate biopsies in the Gauteng province, South Africa: Lessons learnt

“…While the ICD-O-3 codes are particularly important for PCa cases, the importance of additional benign findings is especially important for inflammation and hypertrophy that have been shown to be linked with many other cancers. 39 , 40 Several studies have indicated that chronic inflammation has a potential role in prostatic carcinogenesis and tumour progression. 39 , 41 , 42 Nelson et al reported that chronic or recurrent inflammation may play a role in the development of PCa.…”