Advanced liver fibrosis by transient elastography, <scp>F</scp>ibrosis 4, and alanine aminotransferase/platelet ratio index among <scp>A</scp>sian hepatitis <scp>C</scp> with and without human immunodeficiency virus infection: Role of vitamin <scp>D</scp> levels

Avihingsanon, Anchalee; Jitmitraparp, Salyavit; Tangkijvanich, Pisit; Ramautarsing, Reshmie; Apornpong, Tanakorn; Jirajariyavej, Supunee; Putcharoen, Opass; Treeprasertsuk, Sombat; Akkarathamrongsin, Srunthron; Poovorawan, Yong; Matthews, Gail V.; Lange, Joep M. A.; Ruxrungtham, Kiat

doi:10.1111/jgh.12613

Cited by 33 publications

(32 citation statements)

References 34 publications

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“…Some studies have continued to report higher progression rates in coinfected compared to mono-infected patients (73, [80][81][82][83][84][85][86][87][88][89] whilst others have shown similar rates (90-95) ( Table 1).…”

Section: Differences In Fibrosis Progressionmentioning

confidence: 95%

Natural history and treatment of HCV/HIV coinfection: Is it time to change paradigms?

Arends

Lieveld

Boeijen

et al. 2015

Journal of Hepatology

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Section: Differences In Fibrosis Progressionmentioning

confidence: 95%

Natural history and treatment of HCV/HIV coinfection: Is it time to change paradigms?

Arends

Lieveld

Boeijen

et al. 2015

Journal of Hepatology

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“…Previous investigations have identified an inverse relation between serum vitamin D level and stage of fibrosis [11-13]. In a recent meta-analysis, vitamin D levels of <10 ng/mL and <30 ng/mL were associated with significant odds of advanced fibrosis [12].…”

Section: Introductionmentioning

confidence: 99%

“…In a recent meta-analysis, vitamin D levels of <10 ng/mL and <30 ng/mL were associated with significant odds of advanced fibrosis [12]. Additionally, an investigation in an Asian cohort of HCV and HCV/HIV coinfection found vitamin D deficiency to be an independent predictor for advanced fibrosis [13]. …”

Section: Introductionmentioning

confidence: 99%

25-Vitamin D levels in chronic hepatitis C infection: association with cirrhosis and sustained virologic response

Backstedt

Pedersen

Choi

et al. 2017

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BackgroundLow serum 25-Vitamin D levels are associated with advanced fibrosis in hepatitis C infection. Vitamin D supplementation has been hypothesized to augment response rates to interferon-based therapy. To date, no investigation has evaluated vitamin D levels during direct-acting antiviral therapy. We aimed to evaluate the prevalence of vitamin D deficiency in cirrhotic and non-cirrhotic cohorts, the predictive value of pretreatment levels for a sustained virologic response, and the changes in 25-OH vitamin D levels during direct-acting antiviral therapy.MethodsTwo hundred eighteen patients with chronic hepatitis C who completed direct-acting antiviral therapy were consecutively enrolled. Vitamin D levels were measured using chemiluminescence immunoassay, prior to initiation and at completion of therapy. Advanced liver fibrosis (cirrhosis) was determined by biopsy, FibroSURE blood test, or imaging.ResultsA sustained virologic response was achieved in 79% (n=172) of patients, with 19% (n=44) relapsing. A total of 123 (56.4%) patients were cirrhotic. The prevalence of Vitamin D deficiency (10-20 ng/mL) and severe deficiency (<10 ng/mL) was significantly higher in cirrhotic patients (P=0.04). Pre-treatment vitamin D levels in cirrhotic patients were negatively correlated with Model for End-Stage Liver Disease score, total bilirubin and INR (P<0.05). Neither pretreatment vitamin D level nor the change during therapy was associated with an increased rate of sustained virologic response.ConclusionsThe prevalence of vitamin D deficiency is higher in hepatitis-C–related cirrhotic cohorts compared to non-cirrhotic patients and correlates with components of hepatic function. Neither pretreatment vitamin D level nor the change during therapy was associated with an increased rate of sustained virologic response.

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“…These studies were based on liver biopsy. However, in addition to their small number, studies based on TE also lack cohorts with liver disease of various etiologies and Asian patients 13,16. This is the first study to assess the factors associated with advanced liver fibrosis by TE in various etiologies and Asian patients.…”

Section: Discussionmentioning

confidence: 99%

Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease

Kim

et al. 2016

Gut and Liver

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Background/AimsDeficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD.MethodsSerum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant.ResultsThe most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001).ConclusionsPatients with compensated CLD exhibit a close correlation between vitamin D level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis.

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Advanced liver fibrosis by transient elastography, Fibrosis 4, and alanine aminotransferase/platelet ratio index among Asian hepatitis C with and without human immunodeficiency virus infection: Role of vitamin D levels

Abstract: HIV infection, Fib-4 score > 1.45, and hypovitaminosis D are strong and independent predictors for the presence of advanced fibrosis in our HCV-infected patients. These data highlight the urgent need of HCV treatment and vitamin D supplement in resource-limited settings.

Cited by 33 publications

References 34 publications

Natural history and treatment of HCV/HIV coinfection: Is it time to change paradigms?

Natural history and treatment of HCV/HIV coinfection: Is it time to change paradigms?

25-Vitamin D levels in chronic hepatitis C infection: association with cirrhosis and sustained virologic response

Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease

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