Advanced Hydrogel systems for mandibular reconstruction

Concentration-Dependent Efficacy of Recombinant Human Bone Morphogenetic Protein-2 Using a HA/β-TCP Hydrogel Carrier in a Mini-Pig Vertebral Oblique Lateral Interbody Fusion Model

“…In various studies, the hydrogel has shown various therapeutic effects such as angiogenesis, osteogenesis, with inflammatory reaction avoided [42,43]. It provides an appropriate microenvironment for recovery-related cells such as endothelial cells, osteoblasts, and mesenchymal stem cells to migrate because of its synthesis method and degradation rate regulation [44].…”

The effect of drug holiday on preventing medication-related osteonecrosis of the jaw in osteoporotic rat model

“…The suppressed bone turnover by the inhibition of osteoclasts, is thought to be one of the most important pathogenic mechanisms of MRONJ [ [42] , [43] , [44] ]. The alveolar bone of the jaws is remodelled daily with a high rate of bone turnover and subjected to a wide variety of stresses; while the prolonged use of BPs causes excessive reduction of bone turnover with accumulation of microcracks resulting in an increased risk of bone necrosis in osseous repair [ 7 , [45] , [46] , [47] ]. This theory partially explains the exclusive occurrence of MRONJ in jawbone.…”

Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

“…3F). 199,236,274,275 Due to the reversible linkages within the networks, the crosslinked hydrogels exhibit low viscosity under shear stress and re-gel rapidly with the removal of stress, and thus these hydrogels are endowed with favorable self-healing and shear-thinning properties. 199 As a result, the dynamic crosslinking maintains the integrity of the hydrogels, and also mechanically protects the encapsulated cells from shear damage during injection.…”