Advanced hybrid nanomaterials

Taubert, Andreas; Leroux, Fabrice; Rabu, Pierre; Bermúdez, V. de Zea

doi:10.3762/bjnano.10.247

Cited by 11 publications

(8 citation statements)

References 39 publications

(36 reference statements)

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“…[ 22,23 ] The resulting matrix can also be hydrophobic, which complicates cell adhesion, and therefore additional modification of the matrix is needed. [ 24–29 ] Simple methods for obtaining nanofibrillar structures mimicking the ECM is based on using of hydrogels. [ 30,31 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 56,63,64 ] Cell adhesion features to GG hydrogels have been provided only by the combination with gelatin, [ 65 ] GG modification with a GRGDS peptide [ 66 ] sequence and mineralization with calcium and magnesium carbonates. [ 60,67 ] Also, there are different approaches for enhancing cell adhesion properties, including hybrid materials, [ 28,29 ] where inorganic components (often nanoparticles) directly stimulate the cell growth by incorporation of such biomolecules as alkaline phosphatase. [ 68,69 ] Nanoparticles have been recognized for affecting the polymeric structures, [ 70,71 ] so controlled nanoparticle adsorption [ 72 ] at biointerfaces has been shown, on the one hand, to serve as activation centers, [ 73 ] while, on the other hand, to promote cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

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Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Abalymov

Santos

Meeren

et al. 2021

Adv Materials Inter

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Nanofibrillar structures are of importance in biomedicine, including lung, cardiovascular, liver, skin, neuroscience research, and tissue engineering. Developing advanced materials and interfaces should contribute to uncovering the mechanisms of diseases aiming to find cure. The similarity between the extracellular matrix (ECM) of soft tissue and hydrogels, characterized by a high water‐content viscoelastic polymeric fiber, has stimulated the development of hydrogels for biomedical applications. However, most hydrogels have a meshy structure resulting in poor cell adhesion properties. Here, fabrication of gellan gum (GG) hydrogels arranged by thermally driven self‐assembly into a network of nanofibers is reported. Mechanical properties of such nanofibrillar hydrogels are analyzed on micro‐ and macroscales. As a result, and in sharp contrast to commonly produced meshy GG hydrogels, the nanofiber‐based hydrogels facilitate the adherence and lead to proliferation of cells. This is assigned to microstructural rearrangements characterized by a changing density and pore size decrease, accompanied with a lower water content. Cell growth on such nanofibrillar structures is investigated for osteoblasts, which are chosen as a model system. The developed nanofibrous interfaces in this study are envisioned to be applicable for growing various types of cells and they should contribute to better understanding cell interactions with ECM.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Abalymov

Santos

Meeren

et al. 2021

Adv Materials Inter

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“…It was fabricated by incorporating natural blue indigo encapsulated within the channels of a clay mineral, palygorskite [14]. The hybrid material involves stabilization of the indigo derivative into magnesium aluminium phyllosilicate [15]. Hybrid materials have been commercialized since the 1950s.…”

Section: History Of Hybrid Nanomaterialsmentioning

confidence: 99%

“…The hybrid approach for material synthesis is called a Lego © -like approach. Furthermore, the modern approach is to integrate hybrid systems into miniaturization devices [14,16]. The rapid growth and development of HNs have by now made a nice platform for the administration of drugs and smart materials responsive to a stimulus and the development of sensors.…”

Section: History Of Hybrid Nanomaterialsmentioning

confidence: 99%

“…Their advanced characteristics, task specificity, and miniaturization quality have made them distinct from other materials bringing about a rapid rise in their growth and demand. The multidisciplinary of this scientific trend, as well as the integration of the advantageous and superior properties of both organic and inorganic materials, is pivotal to developing multifunctional materials based on building blocks [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Hybrid Nanomaterials: Historical Developments, Classification and Biomedical Applications

Ibedita¹

2023

Emerging Nanomaterials and Their Impact on Society in the 21st Century

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Hybrid nanomaterials (HNs) have exceptional physical and chemical properties and combine superior qualities of both inorganic and organic materials to exploit them to desirable chemistry through imposing multifunctionality in a single material. Strategies of synthesis of HNs involve the fabrication of components, either organic or inorganic, through the insertion of molecules or nano-objects or polymerization of precursors. The interconnected porous network of HNs also enables a range of applications. In this chapter, we have discussed historical development, strategies of synthesis, and, classification of HNs with emphasis on advancement for biomedical applications.

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