Advanced Glycation End Products Are Associated with Diabetes Status and Physical Functions in Patients with Cardiovascular Disease

Hirai, Tomoya; Fujiyoshi, Kazuhiro; Yamada, Satoru; Matsumoto, Takuya; Kikuchi, Junko; Ishida, Kohki; Ishida, Miwa; Yamaoka‐Tojo, Minako; Inomata, Takayuki; Shigeta, K.; Tojo, Taiki

doi:10.3390/nu14153032

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Previous studies have shown that AGEs may cause cardiac and vascular dysfunction in two ways: vascular stiffness and cardiac fibrosis through the cross-linking of elastin and collagen; inflammation and oxidative stress through AGER. 22 Both in vivo and in vitro studies conducted by Zhong et al suggest that the endoplasmic reticulum stress induced by AGEs can mediate the activation of PERK/CaN/NFAT4c signal transduction in cardiac microvascular endothelial cells, and then trigger the transcription of targeted genes, leading to apoptosis, inflammation, and micro thrombosis, thereby exacerbating microvascular dysfunction in non-obstructive coronary artery disease. 23 Liang B et al also found that the AGEs-RAGE axis mediates myocardial fibrosis by activating autophagy-induced cardiac fibroblasts in heart failure.…”

Section: Discussionmentioning

confidence: 99%

Serum Pentosidine is Associated with Cardiac Dysfunction and Atherosclerosis in T2DM

Cao¹,

Ye²,

Yuan³

et al. 2023

DMSO

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Aim The purpose of this paper is to investigate the relationship between serum pentosidine levels and cardiac function and vascular disease in diabetic patients, and to provide a new reference indicator for the early detection of diabetic cardiovascular complications. Materials and Methods This was a cross-sectional study. One hundred and twenty-two patients with type 2 diabetes were grouped by LVEF quartiles to compare the differences between their clinical data and serum pentosidine levels. Also, the correlation between serum pentosidine and clinical indicators was assessed. The effect of serum pentosidine on cardiac function and vascular stiffness was analyzed by multiple stepwise regression. Results Serum pentosidine levels were higher in patients with LVEF ≤57%. Serum pentosidine levels were positively correlated with waist-to-hip ratio, hemoglobin, AIP, baPWV, LVESD, and ARD, and negatively correlated with LVEF. Low serum pentosidine was associated with increased LVESD; high pentosidine was significantly associated with increased ARD, high AIP and high baPWV. Conclusion The results suggest that serum pentosidine, a member of AGEs, may reflect cardiac remodeling and dysfunction as well as atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Serum Pentosidine is Associated with Cardiac Dysfunction and Atherosclerosis in T2DM

Cao¹,

Ye²,

Yuan³

et al. 2023

DMSO

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Association between fingertip-measured advanced glycation end products and cardiovascular events in outpatients with cardiovascular disease

Hirai,

Fujiyoshi,

Yamada

et al. 2023

Cardiovasc Diabetol

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Background The accumulation of advanced glycation end products (AGEs) is associated with cardiovascular events in patients with cardiovascular disease (CVD). However, the relationship between the AGEs measured by an AGEs sensor noninvasively at the fingertip and prognosis in patients with CVD remains unclear. Therefore, this study aimed to determine the relationship between AGEs score and prognosis among patients with CVD. Methods A total of 191 outpatients with CVD were included. AGEs score were measured using an AGEs sensor and the patients were classified into groups by the median value of AGEs score. The incidence of major adverse cardiovascular and cerebrovascular events (MACCE) at 30 months was compared between high- and low-AGEs score groups. In addition, receiver operating characteristic (ROC) curve analysis was used to calculate cutoff value for the AGEs score, which discriminates the occurrence of MACCE. Cox regression analysis was performed to identify the factors associated with the presence of MACCE. MACCE included cardiac death, myocardial infarction, percutaneous coronary intervention, heart failure, and stroke. Results AGEs score was normally distributed, with a median value of 0.51. No significant intergroup differences were found in laboratory findings, physical functions, or medications. The high-AGEs score group had a significantly higher incidence of MACCE than the low-AGEs score group (27.1 vs. 10.5%, P = 0.007). A high-AGEs score was a risk factor for MACCE (hazard ratio, 2.638; 95% confidence interval, 1.271–5.471; P = 0.009). After the adjustment for confounders other than 6-min walking distance, the AGEs score remained a factor associated with the occurrence of MACCE. The best cutoff AGEs score for the detection of MACCE was 0.51 (area under the curve, 0.642; P = 0.008; sensitivity, 72.2%; specificity, 54.8%). Conclusions AGEs score measured at the fingertip in patients with CVD is associated with MACCE. AGEs score, which can be measured noninvasively and easily, may be useful as an assessment for the secondary prevention of CVD in patients with CVD.

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Discovery of age-related early-stage glycated proteins based on deep quantitative serum glycated proteome analysis

Ren,

Wu,

Zhang

et al. 2023

ABBS

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Aging is a pressing global health issue that is linked to various diseases, such as diabetes and Alzheimer’s disease. It is well known that glycation plays a pathological role in the aging process and age-related diseases. Thus, it is of great significance to discover protein glycation at an early stage for monitoring and intervention in the aging process. However, the endogenous age-related early-stage glycated proteome remains insufficiently profiled. To address this research gap, our study focuses on assessing glycated proteomics profiles in the serum of mice. We employ a robust and quantitative strategy previously developed by our team, to analyze endogenous glycated proteome in serum samples of 4 age groups of mice (10 weeks, 16 weeks, 48 weeks and 80 weeks). In total, 2959 endogenous glycated peptides corresponding to 296 serum proteins are identified from 48 runs of serum samples from 16 mice across the four age groups. By comparing these glycated peptides between adjacent age groups, we discover 49 glycated peptides from 35 proteins that show significant upregulation between the 48-week and 80-week age groups. Furthermore, we identify 10 glycated proteins (or protein groups) that are significantly upregulated only between the 48-week and 80-week age groups, including lecithin-cholesterol acyltransferase (LCAT) and apolipoprotein A-II (Apo A-II). These novel findings provide unique signatures for understanding the aging process and age-related diseases. By shedding light on the early-stage glycated proteome, our study contributes valuable insights that may have implications for future interventions and therapeutic approaches.

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Advanced Glycation End Products Are Associated with Diabetes Status and Physical Functions in Patients with Cardiovascular Disease

Cited by 3 publications

References 35 publications

Serum Pentosidine is Associated with Cardiac Dysfunction and Atherosclerosis in T2DM

Serum Pentosidine is Associated with Cardiac Dysfunction and Atherosclerosis in T2DM

Association between fingertip-measured advanced glycation end products and cardiovascular events in outpatients with cardiovascular disease

Discovery of age-related early-stage glycated proteins based on deep quantitative serum glycated proteome analysis

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