Advanced glycation end-products and advanced oxidation protein products in schizophrenia

Pandolfo, Gianluca; Genovese, Giovanni; Bruno, Antonio; Campolo, Domenica; Tigano, Valeria; Cristani, Mariateresa; Casciaro, Marco; Pioggia, Giovanni; Gangemi, Sebastiano

doi:10.1016/j.psychres.2022.114527

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…A reduced gene expression of anti-oxidative enzymes has been described in oligodendrocytes of the Locus coeruleus and the occipital cortex in post-mortem brain analyses of depression compared to healthy controls [29]. In schizophrenia, oxidative stress, measured by an increase of oxidized proteins compared to the controls, is considered an important factor in the onset and progress of the disease, besides other factors [30]. Furthermore, genetic alterations in oxidative pathways are associated with schizophrenia [31].…”

Section: Inflammation and Oxidative Stress Contribute To Psychiatric ...mentioning

confidence: 99%

Modulation of neuroinflammation and oxidative stress by targeting GPR55 – new approaches in the treatment of psychiatric disorders

Apweiler,

Saliba,

Sun

et al. 2024

Mol Psychiatry

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Pharmacological treatment of psychiatric disorders remains challenging in clinical, pharmacological, and scientific practice. Even if many different substances are established for treating different psychiatric conditions, subgroups of patients show only small or no response to the treatment. The neuroinflammatory hypothesis of the genesis of psychiatric disorders might explain underlying mechanisms in these non-responders. For that reason, recent research focus on neuroinflammatory processes and oxidative stress as possible causes of psychiatric disorders. G-protein coupled receptors (GPCRs) form the biggest superfamily of membrane-bound receptors and are already well known as pharmacological targets in various diseases. The G-protein coupled receptor 55 (GPR55), a receptor considered part of the endocannabinoid system, reveals promising modulation of neuroinflammatory and oxidative processes. Different agonists and antagonists reduce pro-inflammatory cytokine release, enhance the synthesis of anti-inflammatory mediators, and protect cells from oxidative damage. For this reason, GPR55 ligands might be promising compounds in treating subgroups of patients suffering from psychiatric disorders related to neuroinflammation or oxidative stress. New approaches in drug design might lead to new compounds targeting different pathomechanisms of those disorders in just one molecule.

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Section: Inflammation and Oxidative Stress Contribute To Psychiatric ...mentioning

confidence: 99%

Modulation of neuroinflammation and oxidative stress by targeting GPR55 – new approaches in the treatment of psychiatric disorders

Apweiler,

Saliba,

Sun

et al. 2024

Mol Psychiatry

View full text Add to dashboard Cite

show abstract

24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder, and Bipolar Disorder

Messedi,

Makni-Ayadi

2023

Advances in Experimental Medicine and Biology

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Are Advanced Oxidation Protein Products (AOPPs) Levels Altered in Neuropsychiatric Disorders? An Integrative Review

de Brum,

Bochi

2024

Mol Neurobiol

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Advanced glycation end-products and advanced oxidation protein products in schizophrenia

Cited by 5 publications

References 22 publications

Modulation of neuroinflammation and oxidative stress by targeting GPR55 – new approaches in the treatment of psychiatric disorders

Modulation of neuroinflammation and oxidative stress by targeting GPR55 – new approaches in the treatment of psychiatric disorders

24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder, and Bipolar Disorder

Are Advanced Oxidation Protein Products (AOPPs) Levels Altered in Neuropsychiatric Disorders? An Integrative Review

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