Advanced Effect of Moringa oleifera Bioconversion by Rhizopus oligosporus on the Treatment of Atopic Dermatitis: Preliminary Study

Hur, Sang-Sun; Choi, Suk-won; Lee, Dong Ryeol; Park, Jong-hwan; Chung, Tae‐Ho

doi:10.1155/2018/7827565

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…Moreover, it has been reported that M. concanensis contains flavonoid compounds, such as quercetin [ 18 ]. Although the beneficial properties of Moringa oleifera in atopic dermatitis have been widely reported [ 19 , 20 ], the effects of M. concanensis in atopic dermatitis are still unknown. In this study, we investigated the anti-inflammatory and the therapeutic effects of M. concanensis leaves in LPS-stimulated HaCaT keratinocytes and a 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis murine model.…”

Section: Introductionmentioning

confidence: 99%

Moringa concanensis L. Alleviates DNCB-Induced Atopic Dermatitis-like Symptoms by Inhibiting NLRP3 Inflammasome-Mediated IL-1β in BALB/c Mice

Kim

Mony

et al. 2022

Pharmaceuticals

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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus, dry skin and redness on the face and inside elbows or knees. Most patients with AD are children and youths, but it can also develop in adults. In the therapeutic aspect, treatment with corticosteroids for AD has several side effects, such as weight loss, atrophy and acne. In the current study, we examined the anti-inflammatory effect of Moringa concanensis leaves on HaCaT keratinocytes and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis-like symptoms in BALB/c mice. We observed that M. concanensis treatment exhibited significant inhibition in the production of inflammatory mediators and proinflammatory cytokines, such as IL-1β, in LPS-induced HaCaT keratinocytes by downregulating the NLRP3 inflammasome activation. Moreover, M. concanensis inhibited the activation of JNK, AP-1 and p65, which resulted in the deformation of NLRP3 in LPS-stimulated HaCaT cells. In mice with DNCB-induced AD-like skin lesions, the administration of M. concanensis ameliorated the clinical symptoms, such as the dermatitis score, thickness of lesional ear skin and TEWL. Furthermore, M. concanensis could attenuate the activation of the immune system, such as reducing the spleen index, concentration of the IgE levels and expression of the NLRP3 inflammasome in ear tissues. Therefore, our results suggest that M. concanensis exerts anti-atopic dermatitis effects by inhibiting the NLRP3 inflammasome-mediated IL-1β.

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Section: Introductionmentioning

confidence: 99%

Moringa concanensis L. Alleviates DNCB-Induced Atopic Dermatitis-like Symptoms by Inhibiting NLRP3 Inflammasome-Mediated IL-1β in BALB/c Mice

Kim

Mony

et al. 2022

Pharmaceuticals

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“…Leaf extracts of M. oleifera presented a positive result for the treatment of atopic dermatitis, with the reduction of serum level of IgE and the clinical characteristics [15]. The aqueous extract of the leaf, with phytochemical compounds, was an important target in neural studies, with action of nicotine, the authors revealed that the aqueous extract was able to prevent chromatolysis, distortion of cerebellar cortical cells and neurobehavioral deficit, in mice treated with nicotine [16].…”

Section: Resultsmentioning

confidence: 99%

MORINGA OLEIFERA: A NEW PERSPECTIVE FOR THE SYNTHESIS OF NATURAL PRODUCTS

Silva

Bezerra

Sousa

et al. 2018

Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th Edition

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Moringa oleifera Lam. is a plant native from India, but its distribution extends to all continents. Its leaves, flowers, pods and seeds are commonly used for food, mainly in Africa, due to its high nutritional value. With regard to medicine, M. oleifera demonstrates immeasurable potential in view of the various biological activities which are reported from its secondary compounds, such as alkaloids, tannins, flavonols, steroids, saponins, coumarins, quinones, resins, lectins among others. Based on this assumption, this review aims to expose the potential of Moringa oleifera in the period 2016-2018, in the use of its compounds for the synthesis of natural products due to its diverse biological activities. The results showed that the several parts of the plant may have different biological activities. The seeds have antibacterial activity with dental importance; activity in the prevention and deceleration of the amyotrophic lateral sclerosis disease (ALS); anti-hypertrophic and anti-fibrotic effect, being beneficial for cardiac structure and function in hypertensive mice; anticancer activity; anti-inflammatory; and protection of neural cells. For the leaves were reported Antitumor activities; therapeutic efficacy against neurotoxicity; for insulin expression and decrease in the degree of insulitis; antimicrobial activity; reduction of myocardial damage and oxidative stress; treatment in atopic dermatitis; gastroprotective activity and improvement of mucus; hypocholesterolemic effect; and ability to prevent chromatolysis, distortion of cerebellar cortical cells and neurobehavioral deficit. For the other parts of the plant similar activities are described, however in less quantity. Thus, Moringa oleifera presents a new perspective on the synthesis of natural products, considering the range of biological activities described for a species, as well as the ease of obtaining and using its compounds.

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“…This condition is caused by inflammation of the skin as a result of increased histamine and inflammatory cytokine levels. (1)(2)(3) According to the World Health Organization Global Burden of Diseases at least 230 million people worldwide suffer from AD. (4) The prevalence of AD in children is about 10% to 20% whereas in adults it is about 5-10%.…”

Section: Introductionmentioning

confidence: 99%

Effect of Physalis angulata leaf extract cream on Interleukin-4, Interleukin-6, and Immunoglobulin-E in mice with induced atopic dermatitis

Ekasari,

Basuki,

Kurniasih

et al. 2023

Univ Med

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BackgroundThe prevalence of atopic dermatitis (AD) and allergic or irritant contact dermatitis has been increasing significantly in the general population. Interleukin- 4 (IL-4), interleukin-6 (IL-6), and immunoglobulin E (IgE) play a key role in the pathogenesis of AD. Physalis angulata (PA) leaves reportedly have anti-inflammatory effects by impeding IL-4, IL-6, and IgE. This study aimed to evaluate the effect of PA leaf extract cream on IL-4, IL-6, and IgE using 2,4-dinitrochlorobenzene (DNCB) to induce AD-like skin inflammation in a mice model. MethodsThis study used an experimental design involving 30 BALB/c mice, that were randomized into 3 groups: 1) control group receiving no treatment; 2) Vehicle treatment group receiving vehicle cream preparation; 3) PA treatment group receiving 10% PA leaf extract cream after induction of AD-like skin inflammation by DNCB. After 30 days, tissue samples were extracted from the skin lesions to measure IL-4 and IL-6 levels, and serum to measure IgE using ELISA. One-way Anova, Kruskal-Wallis and Mann-Whitney tests were used to analyze the data. ResultsGroup 3 (PA treatment) had significantly lower IL-4 (281.15 ± 43.14 pg/mL) than group 2 (vehicle cream treatment) (388.89±135.88 pg/ml) (p=0.001). However, although IL-6 and IgE levels were lower in group 3 than in group 2, the differences were statistically not significant (p=0.096 and p=0.479 respectively). ConclusionThere were lower levels of IL-4, IL-6, and IgE in the group receiving PA leaf extract cream than in the group receiving vehicle cream preparation. Therefore, PA leaf extract cream may have therapeutic potential in AD.

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Advanced Effect of Moringa oleifera Bioconversion by Rhizopus oligosporus on the Treatment of Atopic Dermatitis: Preliminary Study

Cited by 8 publications

References 16 publications

Moringa concanensis L. Alleviates DNCB-Induced Atopic Dermatitis-like Symptoms by Inhibiting NLRP3 Inflammasome-Mediated IL-1β in BALB/c Mice

Moringa concanensis L. Alleviates DNCB-Induced Atopic Dermatitis-like Symptoms by Inhibiting NLRP3 Inflammasome-Mediated IL-1β in BALB/c Mice

<em>MORINGA OLEIFERA</em>: A NEW PERSPECTIVE FOR THE SYNTHESIS OF NATURAL PRODUCTS

Effect of Physalis angulata leaf extract cream on Interleukin-4, Interleukin-6, and Immunoglobulin-E in mice with induced atopic dermatitis

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