Advanced CaCO3-derived delivery systems for bioactive compounds

Tan, Chen; Dima, Cristian; Huang, Meigui; Assadpour, Elham; Wang, Jing; Sun, Baoguo; Kharazmi, Mohammad Saeed; Jafari, Seid Mahdi

doi:10.1016/j.cis.2022.102791

Cited by 19 publications

(22 citation statements)

References 191 publications

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“…This method allowed for homogenous distribution of QT in the microcapsules [ 46 ]. The burst release of QT from the microcapsules within the first hour of incubation indicated that QT could be entrapped within the porous structure of the microcapsules and physically bonded with the CaCO 3 particles [ 47 , 48 ]. The results agree with a previous report that hydrogel encapsulation helped increase QT retention for a gradual release of bioactive molecules at the target sites [ 28 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Calcium Carbonate Microcapsules and Nanohydroxyapatite on Properties of Thermosensitive Chitosan/Collagen Hydrogels

et al. 2023

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Thermosensitive chitosan/collagen hydrogels are osteoconductive and injectable materials. In this study, we aimed to improve these properties by adjusting the ratio of nanohydroxyapatite particles to calcium carbonate microcapsules in a β-glycerophosphate-crosslinked chitosan/collagen hydrogel. Two hydrogel systems with 2% and 5% nanohydroxyapatite particles were studied, each of which had varying microcapsule content (i.e., 0%, 1%, 2%, and 5%). Quercetin-incorporated calcium carbonate microcapsules were prepared. Calcium carbonate microcapsules and nanohydroxyapatite particles were then added to the hydrogel according to the composition of the studied system. The properties of the hydrogels, including cytotoxicity and biocompatibility, were investigated in mice. The calcium carbonate microcapsules were 2–6 µm in size, spherical, with rough and nanoporous surfaces, and thus exhibited a burst release of impregnated quercetin. The 5% nanohydroxyapatite system is a solid particulate gel that supports homogeneous distribution of microcapsules in the three-dimensional matrix of the hydrogels. Calcium carbonate microcapsules increased the mechanical and physical strength, viscoelasticity, and physical stability of the nanohydroxyapatite hydrogels while decreasing their porosity, swelling, and degradation rates. The calcium carbonate microcapsules–nanohydroxyapatite hydrogels were noncytotoxic and biocompatible. The properties of the hydrogel can be tailored by adjusting the ratio of calcium carbonate microcapsules to the nanohydroxyapatite particles. The 1% calcium carbonate microcapsules containing 5% nanohydroxyapatite particle–chitosan/collagen hydrogel exhibited mechanical and physical strength, permeability, and prolonged release profiles of quercetin, which were superior to those of the other studied systems and were optimal for promoting bone regeneration and delivering natural flavonoids.

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Section: Discussionmentioning

confidence: 99%

Effects of Calcium Carbonate Microcapsules and Nanohydroxyapatite on Properties of Thermosensitive Chitosan/Collagen Hydrogels

et al. 2023

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“…For example, CaP and CaCO 3 shells were highly responsive to pH = 5-7, which allowed nanoagents with CaP/ CaCO 3 shells to release CAs gradually into the TME. 19,20 Besides, an undegradable hollow inorganic nano-structure with appropriate modification can also achieve controlled release in the acidic environment. Zhu et al reported a TME activatable 19 F MRI platform (FILAMP) with fluorinated ion liquids (ILs) trapped in hollow mesoporous silica (HMS) and stimuli-responsive copolymer-sealed pores of HMS.…”

Section: Ph-responsive Agent Releasementioning

confidence: 99%

“…81 Moreover, the enzyme furin overexpresses in several cancers such as glioblastomas. A furin-controlled MRI system has also been reported, which can cause simultaneous T 2 1 H MRI enhancement and the 19 F MRI switch to be turned on. In the presence of furin and GSH, furin cleavage and click condensation reactions are performed on them, thus simultaneously turning the MRI signal of 19 F on.…”

Section: •−mentioning

confidence: 99%

“…Acid-soluble and biologically friendly inorganic nanoplatforms, such as CaCO 3 and CaP, are highly appreciated in nanoagent construction because they can protect bioactive agents in the bloodstream and control drug release for targeted delivery. [19][20][21] Liu et al 22 developed a manganese-doped CaP nanoprobe by mixing an aqueous solution of CaCl 2 and MnCl 2 with 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid buffer containing Na 2 HPO 4 . The probe effectively disassociated at pH 6.5 and released Mn 2+ , which further induced T 1 -weighted relaxivity (r 1 ) by binding with the surrounding proteins and H 2 O molecules at a mildly acidic tumour site.…”

Section: Ph-responsive Agent Releasementioning

confidence: 99%

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Bioparameter-directed nanoformulations as MRI CAs enable the specific visualization of hypoxic tumour

Lu,

Wang,

Gao

et al. 2023

Analyst

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“…Vaterite is metastable and transforms to either aragonite or calcite upon contact with water. Calcite crystals are rhombohedral, aragonite has needle crystals and mainly exists in the shell of mollusks, whereas vaterite forms cauliflower-like spheres or disks which are built by smaller entities [ 16 , 17 , 18 ]. Thus, the vaterite crystals are obtained by assembly into larger particulate structures and this makes the vaterite phase porous with a relatively high surface area in comparison with calcite and aragonite.…”

Section: Introductionmentioning

confidence: 99%

A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly Soluble Drugs

Ambrogi

2023

Pharmaceutics

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Calcium carbonate is an excipient traditionally used in solid dosage forms with several functions such as a diluent, a quick dissolution agent, a buffer and an opacifier. Recently, many other challenges have arisen for calcium carbonate and, among them, the possibility of using it as an excipient for improving the dissolution rate of poorly soluble drugs. As a consequence of their poor solubility in biological fluids, many active ingredients suffer from low and erratic bioavailability when administered by the oral route and thus, many formulation strategies and excipients have been proposed to overcome this problem. Among them, calcium carbonate has been proposed as an excipient for improving dissolution rates. Calcium carbonate has many interesting characteristics, in fact it dissolves quickly in gastric fluid, is inexpensive and is safe. It exists in different polymorphic forms and in porous morphology and recently a porous functionalized calcium carbonate has been proposed as a new excipient. This review is the first overview on the use of calcium carbonate as an excipient for improving drug dissolution rates. The drug loading procedure, the physical characterization of the drug/CaCO3 samples and their dissolution profiles will be described. Moreover, the possible mechanisms of dissolution improvement, such as the presence of the drug in amorphous or polymorphic forms, in small crystals, and the effects of CaCO3 dissolution in acidic medium will be discussed. Different polymorphic forms of calcium carbonate and the presence of porosity and functionalization will be analyzed as well and their effects on dissolution rates will be discussed.

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Advanced CaCO3-derived delivery systems for bioactive compounds

Cited by 19 publications

References 191 publications

Effects of Calcium Carbonate Microcapsules and Nanohydroxyapatite on Properties of Thermosensitive Chitosan/Collagen Hydrogels

Effects of Calcium Carbonate Microcapsules and Nanohydroxyapatite on Properties of Thermosensitive Chitosan/Collagen Hydrogels

Bioparameter-directed nanoformulations as MRI CAs enable the specific visualization of hypoxic tumour

A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly Soluble Drugs

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