Advanced breast cancer incidence following population-based mammographic screening

Autier, Philippe; Boniol, Mathieu; Middleton, Richard; Doré, Jean; Héry, Clarisse; Zheng, Tongzhang; Gavin, Anna

doi:10.1093/annonc/mdq633

Cited by 114 publications

(79 citation statements)

References 57 publications

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“…Most of the decreasing trends, as well as the most rapid declines, occurred in high-income countries. These reductions have been attributed to early detection through mammography and improved treatment; although the respective contributions of each are unclear and likely vary depending on the level of participation in regular screening and the availability and prompt administration of state-of-the-art treatment (21,(49)(50)(51)(52)(53)(54). A study of cancer survival in 67 countries reported that 5-year breast cancer survival increased steadily in most high-income countries, as well as in several countries in Central and Southern America (17).…”

Section: Discussionmentioning

confidence: 99%

International Variation in Female Breast Cancer Incidence and Mortality Rates

DeSantis

Bray

Ferlay

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

648

449

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Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide. Herein, we examine global trends in female breast cancer rates using the most up-to-date data available.Methods: Breast cancer incidence and mortality estimates were obtained from GLOBOCAN 2012 (globocan.iarc.fr). We analyzed trends from 1993 onward using incidence data from 39 countries from the International Agency for Research on Cancer and mortality data from 57 countries from the World Health Organization.Results: Of 32 countries with incidence and mortality data, rates in the recent period diverged-with incidence increasing and mortality decreasing-in nine countries mainly in Northern/ Western Europe. Both incidence and mortality decreased in France, Israel, Italy, Norway, and Spain. In contrast, incidence and death rates both increased in Colombia, Ecuador, and Japan.

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Section: Discussionmentioning

confidence: 99%

International Variation in Female Breast Cancer Incidence and Mortality Rates

DeSantis

Bray

Ferlay

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

648

449

View full text Add to dashboard Cite

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“…But the authors concluded in the last sentence of their abstract in contrast to their findings that, ''It is evident that breast cancer screening contributes to a reduction in advanced breast cancers and breast cancer mortality'' [53]. A systematic review from 2011 that included seven countries and regions found that, on average, the rates of advanced cancers, defined as those larger than 20 mm, were not affected by screening [55].…”

Section: No Decrease In Advanced Cancersmentioning

confidence: 91%

Why mammography screening has not lived up to expectations from the randomised trials

Gøtzsche

Jørgensen

Zahl

et al. 2011

Cancer Causes Control

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We analysed the relation between tumour sizes and stages and the reported effects on breast cancer mortality with and without screening in trials and observational studies. The average tumour sizes in all the trials suggest only a 12% reduction in breast cancer mortality, which agrees with the 10% reported in the most reliable trials. Recent studies of tumour sizes and tumour stages show that screening has not lowered the rate of advanced cancers. In agreement with this, recent observational studies of breast cancer mortality have failed to find an effect of screening. In contrast, screening leads to serious harms in healthy women through overdiagnosis with subsequent overtreatment and false-positive mammograms. We suggest that the rationale for breast screening be urgently reassessed by policy-makers. The observed decline in breast cancer mortality in many countries seems to be caused by improved adjuvant therapy and breast cancer awareness, not screening. We also believe it is more important to reduce the incidence of cancer than to detect it 'early.' Avoiding getting screening mammograms reduces the risk of becoming a breast cancer patient by one-third.

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“…There is an urgent need to adopt corrective strategies best suited to local culture and resources for early diagnosis and affordable appropriate treatment of breast cancer in these countries. Population based mammographic screening program is neither affordable nor feasible in the current scene (Badar et al, 2011) as a recent review shows that it is not associated with decrease in the incidence of advanced breast cancer (Autier et al, 2011).…”

Section: 693 Clinicopathologic Profile Of Breast Cancer Patients In mentioning

confidence: 99%

Clinicopathologic Profile of Breast Cancer Patients in Pakistan: Ten Years Data of a Local Cancer Hospital

Khokher¹,

Qureshi²,

Riaz³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Breast cancer is the most frequent cancer of women worldwide, with considerable geographic and racial/ ethnic variation. Data are generally derived from population based cancer registries in the developed countries but hospital data are the most reliable source in the developing countries. Ten years data from 1st Jan 2000 to 31st Dec 2009 of a cancer hospital in Pakistan were here analyzed by descriptive statistics to evaluate the clinicopathologic profile of local breast cancer patients. Among 28,740 cancer patients, 6,718 were registered as breast cancer. The female to male ratio was 100:2. Breast cancer accounted for 23% of all and 41% of female cancers. Some 46% were residents of Lahore, with a mean age of 47±12 years. Less than 1% were at Stage 0 and 10%, 32%, 35% and 23% were at Stage I, II, III and IV respectively. Histopathology was unknown in 4% while 91%, 2% and 1% had invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC) and mucinous carcinoma respectively. Rare carcinomas accounted for the rest. Tumor grade 1, 2 and 3 was 11%, 55% and 34% among the known. Profile of breast cancer patients in Pakistan follows a pattern similar to that of other developing countries with earlier peak age and advanced disease stage at presentation. The male breast cancer accounts for higher proportion in the local population. Local women have higher frequency of IDC and lower frequency of ILC and DCIS, owing probably to a different risk profile. Use of hospital information systems and establishment of population based cancer registry is required to have accurate and detailed local data. Promotion of breast health awareness and better health care system is required to decrease the burden of advanced disease.

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Advanced breast cancer incidence following population-based mammographic screening

Cited by 114 publications

References 57 publications

International Variation in Female Breast Cancer Incidence and Mortality Rates

International Variation in Female Breast Cancer Incidence and Mortality Rates

Why mammography screening has not lived up to expectations from the randomised trials

Clinicopathologic Profile of Breast Cancer Patients in Pakistan: Ten Years Data of a Local Cancer Hospital

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