Advanced biomaterials in cell preservation: Hypothermic preservation and cryopreservation

Ma, Yiming; Gao, Lei; Tian, Yunqing; Chen, Pengguang; Yang, Jing; Zhang, Lei

doi:10.1016/j.actbio.2021.07.001

Cited by 48 publications

(35 citation statements)

References 240 publications

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“…Furthermore, they may depend on the cross-linking between the adsorbent matrix and the adsorbate explained by electrostatic interactions [ 40 ], resulting, therefore, in a search for antioxidant biomaterials that present high rates of release of their components in a continuous and prolonged way [ 45 , 55 ], ensuring, then, that antioxidant biomaterials can play a key role in a wide range of applications, including nanodrug delivery systems, cell preservation (hypothermic and cryopreservation), food preservation (pathogen control agents, packaging and biosensors), edible packaging or food stabilizers, water treatment, orthopedic and dental coverings, wound dressing, and cosmetics with a protective and/or anti-aging effect [ 55 , 56 ].…”

Section: Biomaterialsmentioning

confidence: 99%

The Importance of Antioxidant Biomaterials in Human Health and Technological Innovation: A Review

et al. 2022

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Biomaterials come from natural sources such as animals, plants, fungi, algae, and bacteria, composed mainly of protein, lipid, and carbohydrate molecules. The great diversity of biomaterials makes these compounds promising for developing new products for technological applications. In this sense, antioxidant biomaterials have been developed to exert biological and active functions in the human body and industrial formulations. Furthermore, antioxidant biomaterials come from natural sources, whose components can inhibit reactive oxygen species (ROS). Thus, these materials incorporated with antioxidants, mainly from plant sources, have important effects, such as anti-inflammatory, wound healing, antitumor, and anti-aging, in addition to increasing the shelf-life of products. Aiming at the importance of antioxidant biomaterials in different technological segments as biodegradable, economic, and promising sources, this review presents the main available biomaterials, antioxidant sources, and assigned biological activities. In addition, potential applications in the biomedical and industrial fields are described with a focus on innovative publications found in the literature in the last five years.

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Section: Biomaterialsmentioning

confidence: 99%

The Importance of Antioxidant Biomaterials in Human Health and Technological Innovation: A Review

et al. 2022

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“…Sperm is one kind of cell, and there are many common injuries for sperm and other cells that need in vitro preservation for a longer period of time. One of the main problems of somatic cell preservation is the loss of Extracellular Matrix (ECM), which probably becomes a problem for the preservation of testicular tissues but not for sperm [ 53 ]. These injuries accumulate, which in turn manifest as a decline of sperm motility, membrane and DNA damage, and, ultimately, cellular apoptosis and necrosis.…”

Section: Sperm Injuries During Prolonged Non-freezing Storagementioning

confidence: 99%

Extend the Survival of Human Sperm In Vitro in Non-Freezing Conditions: Damage Mechanisms, Preservation Technologies, and Clinical Applications

Cheng

Jiang

et al. 2022

Cells

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Preservation of human spermatozoa in vitro at normothermia or hypothermia maintaining their functions and fertility for several days plays a significant role in reproductive biology and medicine. However, it is well known that human spermatozoa left in vitro deteriorate over time irreversibly as the consequence of various stresses such as the change of osmolarity, energy deficiency, and oxidative damage, leading to substantial limitations including the need for semen examinations, fertility preservation, and assisted reproductive technology. These problems may be addressed with the aid of non-freezing storage techniques. The main and most effective preservation strategies are the partial or total replacement of seminal plasma with culture medium, named as extenders, and temperature-induced metabolic restriction. Semen extenders consist of buffers, osmolytes, and antioxidants, etc. to protect spermatozoa against the above-mentioned adverse factors. Extended preservation of human spermatozoa in vitro has a negative effect on sperm parameters, whereas its effect on ART outcomes remains inconsistent. The storage duration, temperature, and pre-treatment of semen should be determined according to the aims of preservation. Advanced techniques such as nanotechnology and omics have been introduced and show great potential in the lifespan extension of human sperm. It is certain that more patients will benefit from it in the near future. This review provided an overview of the current knowledge and prospects of prolonged non-freezing storage of human sperm in vitro.

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“…ROS can attack proteins, DNA, cell membrane, and also microtubules, thereby disrupting oocyte structure and function [36,38]. Since vitrified oocytes are under oxidative stress, antioxidants are introduced in conventional cryo-solutions to protect oocytes from cryoinjuries [5,[39][40][41][42]. N-acetylcysteine [40] can improve the quality of mature mouse oocytes after vitrification, melatonin [5] can enhance the efficiency of human oocytes' cryopreservation and resveratrol [39] improves the development of vitrified bovine embryos.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant procyanidin B2 protects oocytes against cryoinjuries via mitochondria regulated cortical tension

Zhuan

et al. 2022

J Animal Sci Biotechnol

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Background Irreversible cryodamage caused by oocyte vitrification limited its wild application in female fertility preservation. Antioxidants were always used to antagonist the oxidative stress caused by vitrification. However, the comprehensive mechanism underlying the protective role of antioxidants has not been studied. Procyanidin B2 (PCB2) is a potent natural antioxidant and its functions in response to vitrification are still unknown. In this study, the effects of PCB2 on vitrified-thawed oocytes and subsequent embryo development were explored, and the mechanisms underlying the protective role of PCB2 were systematically elucidated. Results Vitrification induced a marked decline in oocyte quality, while PCB2 could improve oocyte viability and further development after parthenogenetic activation. A subsequent study indicated that PCB2 effectively attenuated vitrification-induced oxidative stress, rescued mitochondrial dysfunction, and improved cell viability. Moreover, PCB2 also acts as a cortical tension regulator apart from strong antioxidant properties. Increased cortical tension caused by PCB2 would maintain normal spindle morphology and promote migration, ensure correct meiosis progression and finally reduce the aneuploidy rate in vitrified oocytes. Further study reveals that ATP biosynthesis plays a crucial role in cortical tension regulation, and PCB2 effectively increased the cortical tension through the electron transfer chain pathway. Additionally, PCB2 would elevate the cortical tension in embryo cells at morula and blastocyst stages and further improve blastocyst quality. What’s more, targeted metabolomics shows that PCB2 has a beneficial effect on blastocyst formation by mediating saccharides and amino acids metabolism. Conclusions Antioxidant PCB2 exhibits multi-protective roles in response to vitrification stimuli through mitochondria-mediated cortical tension regulation.

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Advanced biomaterials in cell preservation: Hypothermic preservation and cryopreservation

Cited by 48 publications

References 240 publications

The Importance of Antioxidant Biomaterials in Human Health and Technological Innovation: A Review

The Importance of Antioxidant Biomaterials in Human Health and Technological Innovation: A Review

Extend the Survival of Human Sperm In Vitro in Non-Freezing Conditions: Damage Mechanisms, Preservation Technologies, and Clinical Applications

Antioxidant procyanidin B2 protects oocytes against cryoinjuries via mitochondria regulated cortical tension

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