Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery

Abstract

The encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs. The unique properties of nanoparticles not only allow cancer-specific drug delivery by inherent passive targeting phenomena and adopting active targeting strategies, but also improve the pharmacokinetics and bioavailability of the loaded drugs, leading to enhanced therapeutic efficacy and safety compared to conventional treatment modalities. Small molecule drugs are the most widely used anticancer agents at present, while biological macromolecules, such as therapeutic antibodies, peptides and genes, have gained increasing attention. Therefore, this review focuses on the recent achievements of novel nano-encapsulation in targeted drug delivery. A comprehensive introduction of intelligent delivery strategies based on various nanocarriers to encapsulate small molecule chemotherapeutic drugs and biological macromolecule drugs in cancer treatment will also be highlighted.

Combining nanotechnology with the multifunctional roles of neutrophils against cancer and inflammatory disease

“…1,2 Recent decades have witnessed the rapid advancement of nanobiotechnology, which revolutionizes the conventional treatment methods for a wide range of diseases. 3 In this context, numerous functional nanomaterials have been developed to fabricate drug delivery systems (DDSs) to diagnose and treat multiple diseases. 4 Organic nanomaterials like liposomes, polymers, proteins, dendrimers and exosomes have been widely investigated in the biomedical field due to their versatility, while inorganic nanomaterials like metallic nanoparticles (NPs), black phosphorus, silica-based NPs and carbon-related nanostructures also display excellent research prospect because of their distinctive physiochemical features.…”

Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review

“…In greater doses, this substance is required to cause toxicity. The advancement of nanotechnology has a significant impact on cancer treatment [ 6 ].…”

Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research

“…The application of nanomedicine in cancer therapy, with the aim of striking and selectively destroying the targets, has aroused significant interest both in the academic and the industrial fields [ 3 , 4 ]. Cancer nanomedicine is a constantly progressing science that is based on innovative physicochemical concepts and materials, and has been exploited to design nanotherapeutics, i.e., submicron novel drug-carrier systems, defined as nanocarriers, that may be able to overcome the many limitations of conventional drugs, such as poor water solubility, unfair oral bioavailability, non-specific biodistribution and a lack of targeting ability [ 5 , 6 , 7 , 8 ].…”