Advanced age is not a barrier to chronic intracortical single-unit recording in rat cortex
Nicholas F. Nolta,
Michael B. Christensen,
Patrick A. Tresco
Abstract:IntroductionAvailable evidence suggests that as we age, our brain and immune system undergo changes that increase our susceptibility to injury, inflammation, and neurodegeneration. Since a significant portion of the potential patients treated with a microelectrode-based implant may be older, it is important to understand the recording performance of such devices in an aged population.MethodsWe studied the chronic recording performance and the foreign body response (FBR) to a clinically used microelectrode arra… Show more
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