Advanced Age Attenuates Left Ventricular Filling Efficiency Quantified Using Vortex Formation Time: A Study of Octogenarians With Normal Left Ventricular Systolic Function Undergoing Coronary Artery Surgery

Pagel, Paul S.; Dye, Lonnie; Boettcher, Brent T.; Freed, Julie K.

doi:10.1053/j.jvca.2018.02.002

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…A negative correlation between age and VFT was shown in their measurements (1). Previous studies reported that age was associated with a reduction in LV filling efficiency quantified using VFT, and adverse or negative correlation was found between age and VFT using linear regression analysis (24)(25)(26). Based on this negative correlation, it could be speculated that the value of VFT should be between 6 and 8 for teenagers.…”

Section: Vftvolume and Vftblood In Children And Adolescentsmentioning

confidence: 91%

Vortex formation time as an index of left ventricular filling efficiency: comparison between children volunteers and patients with tetralogy of Fallot

Xiang

Qin

et al. 2022

Transl Pediatr

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Background: Vortex formation time (VFT) had been considered a useful marker for assessing diastolic performance. the VFT assessment of diastolic function using four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) has not been used in repair of tetralogy of Fallot (rTOF) patient. The aims of this study were as follows: (I) establish reference ranges for VFT measurements in healthy children and adolescents using 4D flow CMR imaging; and (II) analyze VFT parameters to assess diastole dysfunction in rTOF patients group. Methods:We acquired the CMR data was of 62 healthy participants (aged 6-18 years; male: 40, female: 22) and 20 patients with rTOF (aged 10-13 years; male: 15, female: 5) using 4D flow and cine sequence in routine chamber view. The VFT was calculated based on comparison of different algorithms from cine measurements (VFT volume ) and 4D flow measurements (VFT blood ). Then, VFT measurements were compared to subject peak filling rate (PFR), age, and cardiac mass using simple linear regression and multiple regression analyses. Data were also categorized according to age for VFT and cardiac functional assessment comparisons between 3 age groups (Group 1: 6-9 years; Group 2: 10-13 years; Group 3: 14-18 years). The correlation of VFT and cardiac function parameters were analyzed in the rTOF group.Results: Normal mean value of VFT volume and VFT blood were 4.25±0.92 and 3.77±1.11 in healthy children participants. The VFT volume was correlated with VFT blood (r=0.61, P<0.001). There was a moderately significant correlation between VFT volume and PFR (r=0.46, P<0.001) and between VFT blood and PFR (r=0.47, P<0.001), age (r=0.41, P=0.002) and left ventricular (LV) mass (r=0.48, P<0.001). Multiple regression analyses demonstrated that VFT volume was independently associated with PFR (T=2.239; P<0.05) and VFT blood (T=4.361; P<0.001). There was a significant difference in VFT volume between healthy controls and rTOF patients (5.44±1.93 vs. 4.27±0.88, P=0.018). Conclusions:The VFT measurements showed that the LV that had appropriate space to form the optimal vortex ring in normal children and adolescents aged 6-18 years old. The VFT volume could potentially be helpful in improving our understanding of LV diastolic dysfunction in rTOF patients.

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Section: Vftvolume and Vftblood In Children And Adolescentsmentioning

confidence: 91%

Vortex formation time as an index of left ventricular filling efficiency: comparison between children volunteers and patients with tetralogy of Fallot

Xiang

Qin

et al. 2022

Transl Pediatr

View full text Add to dashboard Cite

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The Effect of Dobutamine Stress Testing on Vortex Formation Time in Patients Evaluated for Ischemia

Dimitroglou

Aggeli

Rapis

et al. 2020

J. of Cardiovasc. Trans. Res.

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Left ventricular vortex formation time: emerging clinical applications and limitations

Ngiam,

Liong,

Pramotedham

et al. 2023

Singapore Medical Journal

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Vortex formation during left ventricular diastolic filling may provide clinically useful insights into cardiac health. In recent years, there has been growing interest in the measurement of vortex formation time (VFT), especially because it is derived noninvasively. There are important applications of VFT in valvular heart disease, athletic physiology, heart failure and hypertrophic cardiomyopathy. The formation of the vortex as fluid propagates into the left ventricle from the left atrium is important for efficient fluid transport. Quantifying VFT may thus help in evaluating and understanding disease and pathophysiological processes.

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Advanced Age Attenuates Left Ventricular Filling Efficiency Quantified Using Vortex Formation Time: A Study of Octogenarians With Normal Left Ventricular Systolic Function Undergoing Coronary Artery Surgery

Cited by 3 publications

References 44 publications

Vortex formation time as an index of left ventricular filling efficiency: comparison between children volunteers and patients with tetralogy of Fallot

Vortex formation time as an index of left ventricular filling efficiency: comparison between children volunteers and patients with tetralogy of Fallot

The Effect of Dobutamine Stress Testing on Vortex Formation Time in Patients Evaluated for Ischemia

Left ventricular vortex formation time: emerging clinical applications and limitations

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