Advanced age and female sex protect cerebral arteries from mitochondrial depolarization and apoptosis during acute oxidative stress
Charles E. Norton,
Rebecca L. Shaw,
Safa
et al.
Abstract:Aging increases reactive oxygen species (ROS) which can impair vascular function and contribute to brain injury. However, aging can also promote resilience to acute oxidative stress. Therefore, we tested the hypothesis that advanced age protects smooth muscle cells (SMCs) and endothelial cells (ECs) of posterior cerebral arteries (PCAs; diameter, ∼80 μm) during exposure to H2O2. PCAs from young (4–6 months) and old (20–26 months) male and female C57BL/6 mice were isolated and pressurized (~70 mm Hg) to evaluat… Show more
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