Advanced age and apnea-hypopnea index predict subclinical atherosclerosis in patients with obstructive sleep apnea syndrome

Arik, Bilal; İnci, Mehmet Fatih; Gümüş, Cesur; Varol, Kenan; Ege, Meltem Refıker; Doǧan, Ömer Tamer; Zorlu, Ali

doi:10.1186/2049-6958-8-9

Cited by 17 publications

(27 citation statements)

References 29 publications

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“…Galectin-3 and age were independent predictors of coronary atherosclerosis in OSAS patients. Furthermore, the presence and total number of coronary plaques and AHI score were found to be higher in the OSAS group than in the controls and in the severe OSAS group compared to the moderate and mild OSAS groups, which is consistent with previous studies [16][17][18][19][20]. Galectin-3 plays a pivotal role in the development of fibrosis and tissue remodelling in kidney and heart [6].…”

Section: Discussionsupporting

confidence: 81%

“…Furthermore, a significant association was revealed between OSAS and the presence of subclinical atherosclerosis assessed by tomographic CCS in patients with OSAS but with no history of known CAD. Age and AHI were also found to be independent predictors of CCS in OSAS [19]. Kepez et al [20] investigated the direct effects of OSAS on the presence and extent of coronary atherosclerosis by using tomographic CCS on a population asymptomatic for CAD, and it was found to be higher in the severe OSAS group compared to the other OSAS groups.…”

Section: Discussionmentioning

confidence: 99%

“…The association between OSAS and atherosclerosis has been investigated in many recent studies [16][17][18][19][20]. Kwon et al [16] reported a relation between OSAS and coronary calcium score (CCS) progression after adjustment for demographics, behaviours, and body mass index.…”

Section: Discussionmentioning

confidence: 99%

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Galectin-3 is associated with coronary plaque burden and obstructive sleep apnoea syndrome severity

Püşüroğlu

Somuncu

Bolat³

et al. 2017

Kardiol Pol

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A b s t r a c tBackground: Obstructive sleep apnoea syndrome (OSAS) is reported to be associated with hypertension, coronary artery disease, atrial fibrillation, and heart failure. Galectin-3 plays an important role in the regulation of inflammation, development of cardiac fibrosis, and remodelling. A significant relationship between galectin-3 and the total number of coronary plaques and the macrocalcified plaque structures of patients with type 2 diabetes mellitus has been reported. Aim:The aim of this study was to investigate the association between galectin-3 level and coronary plaque burden as well as OSAS severity in patients with OSAS.Methods: A total of 87 consecutive patients with a diagnosis of OSAS and 21 age-and gender-matched control subjects were recruited for the present study. The patients with OSAS were also categorised according to their apnoea hypopnoea index (AHI) as follows: mild (AHI = 5-15), moderate (AHI = 15-30), and severe (AHI > 30). All study subjects underwent coronary computed tomography angiography to detect coronary atherosclerosis. Also, all participants of serum galectin-3 concentrations were measured.Results: Mean galectin-3 level was significantly higher in patients with OSAS compared to control subjects (p < 0.001) and in the severe OSAS group, compared to the moderate and mild OSAS groups (p < 0.001). Correlation analysis indicated significant positive relationships between galectin-3 concentrations and the total number of coronary plaques (p < 0.001), high-sensitivity C-reactive protein (p = 0.001), and severity of OSAS (p < 0.001). In multivariate analysis, galectin-3 (p = 0.01) and age (p = 0.025) were significant independent predictors of coronary atherosclerosis, after adjusting for other risk factors. Also, it has been found that galectin-3 concentration is a predictor of OSAS severity (p = 0.001).Conclusions: Galectin-3 is associated with coronary atherosclerosis and OSAS severity in OSAS patients.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Galectin-3 is associated with coronary plaque burden and obstructive sleep apnoea syndrome severity

Püşüroğlu

Somuncu

Bolat³

et al. 2017

Kardiol Pol

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“…In our recent study, 3 our findings suggest that in patients with moderate or severe OSA syndrome, physicians should be alert for the presence of subclinical atherosclerosis. In this study, we investigated 73 patients who were asymptomatic for coronary artery disease and suspected OSA syndrome.…”

Section: To the Editormentioning

confidence: 50%

Response to Impact of Obstructive Sleep Apnea on Cardiovascular Outcomes in Patients Treated With Percutaneous Coronary Intervention: Rationale and Design of the Sleep and Stent Study

Ege¹

2014

Clinical Cardiology

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“…Although the mechanisms underlying atherosclerosis in patients with SAS remain poorly understood, some research suggests that inflammation may be important in this process. Indeed, inflammation leads to endothelial dysfunction and intermittent hypoxia and reperfusion during repetitive episodes of nocturnal apnea, which may be involved in the generation of highly reactive oxygen radicals and ischemia-reperfusion injury to the vascular wall, resulting in increased risk for atherosclerosis [8]. The prevalence of SAS is markedly higher in patients with chronic kidney disease (CKD) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Association between Plaque Score of the Carotid Artery and the Severity of Sleep Apnea Syndrome in Patients with Chronic Kidney Disease

et al. 2016

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Background: Recently, sleep apnea syndrome (SAS) has been associated with hypertension, cardiovascular disease and death. Patients with chronic kidney disease (CKD) have higher rates of SAS, atherosclerotic complications and death than do patients without CKD. Although the relationship between SAS and atherosclerosis is well known, few papers have described this relationship in humans, especially in CKD patients. Patients and Methods: This was a cross-sectional study of 110 clinically stable, non-dialysis patients with CKD who attended a CKD educational program from April 2014 to September 2015. The diagnosis of SAS and its severity were assessed using a type 3 portable monitor. Other atherosclerosis-related data were obtained from the patients' medical records in order to determine the factors associated with the severity of SAS. Results: 95 men and 15 women with a mean age of 71.4 ± 9.9 years were included in the study. The patients' mean body mass index was 24.0 ± 3.9, their mean blood pressure 134.3 ± 21.2/73.6 ± 13.4 mm Hg and their mean estimated glomerular filtration rate 19.8 ± 9.5 ml/min/1.7 m². Adjusted plaque score was a significant predictor of severe SAS (odds ratio = 1.13, p = 0.0182). Mixed plaque was significantly associated with severe SAS (correlation ratio = 0.48, p < 0.0001). Conclusions: Many patients with CKD also have SAS. Our findings demonstrate the relationship between plaque score and the severity of SAS.

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Advanced age and apnea-hypopnea index predict subclinical atherosclerosis in patients with obstructive sleep apnea syndrome

Cited by 17 publications

References 29 publications

Galectin-3 is associated with coronary plaque burden and obstructive sleep apnoea syndrome severity

Galectin-3 is associated with coronary plaque burden and obstructive sleep apnoea syndrome severity

Response to Impact of Obstructive Sleep Apnea on Cardiovascular Outcomes in Patients Treated With Percutaneous Coronary Intervention: Rationale and Design of the Sleep and Stent Study

Association between Plaque Score of the Carotid Artery and the Severity of Sleep Apnea Syndrome in Patients with Chronic Kidney Disease

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