Advance in the understanding of vasovagal syncope in children and adolescents

Li, Hongxia; L, Gao; Yuan, Yongyi

doi:10.1007/s12519-020-00367-z

Cited by 25 publications

(28 citation statements)

References 30 publications

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“…Atypical vasovagal syncope, which is commoner in older adults, and nonneurogenic syncope can often be erroneously misdiagnosed as falls. We agree with Kenny [49] that a more standardized approach should be adopted in the diagnosis and management of workers presenting with syncope or unexplained falls.…”

Section: Discussionsupporting

confidence: 71%

“…The sudden and brief loss of consciousness that many workers reported may be due to a number of different diseases such as orthostatic hypotension (due to drugs, hypovolemia, primary or secondary autonomic failure, others), neurally-mediated syncope, cardiogenic syncope, and less frequently to other neurologic disorders such as epilepsy, psychogenic syncope, vertebrobasilar transient ischemic attacks), metabolic disorders and intoxication [8,48]. According to the literature, vasovagal is the most common form of syncope [49]. It accounts for 60-80% of cases of syncope, and typically occurs in young adults [4,50].…”

Section: Discussionmentioning

confidence: 99%

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Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope and Falls in Workers

Magnavita¹,

Prinzio²,

Arnesano³

et al. 2021

Preprint

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Syncope and presyncope occurring during work can affect safety and impair occupational performance. Few data are available regarding the prevalence of these events among workers. The possible role of sleep quality, mental stress and metabolic disorders in promoting syncope, presyncope and falls in workers is unknown. In the present study, 741 workers (male 35.4%; mean age 47±11 years), employed in different companies, underwent clinical evaluation and blood tests and completed questionnaires to assess sleep quality, occupational distress and mental disorders. The occurrence of syncope, presyncope and unexplained falls during their working life was assessed by an ad hoc interview. The prevalence of syncope, presyncope and falls of unknown origin was 13.9%, 27.0%, and 10.3%, respectively. The occurrence of syncope was associated with an increased risk of occupational distress (adjusted Odds Ratio aOR: 1.62, Confidence Intervals at 95%: 1.05-2.52), low sleep quality (aOR: 1.79 CI 95%: 1.16-2.77) and poor mental health (aOR: 2.43 CI 95%: 1.52-3.87). Presyncope was strongly associated with occupational distress (aOR: 1.77 CI 95%: 1.25-2.49), low sleep quality (aOR: 2.95 CI 95%: 2.08-4.18) and poor mental health (aOR: 2.61 CI 95%: 1.78-3.84), while no significant relationship was found between syncope or presyncope and metabolic syndrome. These results suggest that occupational health promotion interventions aimed at improving sleep quality, reducing stressors and increasing worker resilience might reduce syncope and presyncope events in the working population.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope and Falls in Workers

Magnavita¹,

Prinzio²,

Arnesano³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Hu et al ( 4 ) reported that the incidence of syncope in children and adolescents aged 2~18 years in Changsha was 17.37%, with significant gender differences in different age groups. Bayram et al ( 5 ) and Li et al ( 6 ) reported that 30–50% of children experienced at least one episode of syncope until the adolescent period, most of whom were females and VVS accounted for 60–80% of all pediatric syncope. Acute OI, such as VVS, usually manifests as syncope, which is a transient loss of consciousness (TLOC) and body balance disorder due to transient cerebral ischemia, characterized by a rapid onset, short duration, and spontaneous recovery ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Biomarkers in Children and Adolescents With Orthostatic Intolerance

et al. 2021

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Orthostatic intolerance (OI) refers to a series of symptoms that occur during upright standing, which can be relieved when returned to the supine position. OI is a common cause of syncope in children and adolescents. In recent years, more and more studies have been carried out to assess the prognosis of OI by using biomarkers, among which, flow-mediated vasodilation, left ventricular ejection fraction and fractional shortening, hemodynamic change during head-up tilt test, detection of 24-h urinary sodium excretion, body mass index, midregional pro-adrenomedullin, and erythrocytic H2S producing rate are relatively stable, inexpensive, and easy to obtain. With the help of biomarkers, individualized treatment can be carried out to improve the long-term prognosis of children and adolescents with OI. This article reviews the prognostic value of biomarkers in children and adolescents with OI.

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“…Серед актуальних проблем дитячої кардіо логії є синкопальні стани, що характеризують ся транзиторною втратою свідомості, часто спричинені постуральним стресом і можуть порушувати якість життя дітей та навіть бути загрозливими для життя [1,2,6,13]. Велика кількість причин, що провокують епізоди син копальних станів і відсутність високоінформа тивних методів їх діагностики, спонукає до проведення досліджень, спрямованих на ви явлення механізмів розвитку синкопе для вив чення впливу на ці механізми [3,19,21].…”

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“…Велика кількість причин, що провокують епізоди син копальних станів і відсутність високоінформа тивних методів їх діагностики, спонукає до проведення досліджень, спрямованих на ви явлення механізмів розвитку синкопе для вив чення впливу на ці механізми [3,19,21]. В іноземних наукових дослідженнях природи синкопе наведено твердження, що синкопальні стани становлять один з аспектів гетерогенної групи захворювань, спричинених порушення ми АНС [8,13,22]. При цьому принциповою особливістю їх виникнення вважається пору шення нормальної серцево судинної регуляції АНС [2,4,7,10].…”

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The features of autonomic nervous system homeostasis and adaptive potential in children with syncope

Kovalchuk¹,

Luchyshyn²

2021

MPU

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The investigation of the nature of syncope shows that it is caused by failure of compensatory reflex mechanisms of the autonomic nervous system. Therefore, the determination of specific parameters of autonomic nervous system homeostasis and adaptive potential improves the approach to determining the clinical predictors of the syncope and facilitate its early diagnosis. Purpose — to determine the nature and compare of autonomic dysregulation and functional changes of in children with syncope of different genesis, to identify the circumstances for the formation of insufficient autonomic regulation. Materials and methods. The enrolled subjects were 125 children with syncope, aged 8–17 years, and 41 controls. Children were divided into three groups for analysis: 81 — with vasovagal syncope, 25 — with syncope due to orthostatic hypotension, 19 — with cardiogenic syncope. All children underwent a clinical and functional examination of the cardiovascular system to identify features of autonomic homeostasis. Results. Autonomic imbalance with a predominance of sympathetic autonomic regulation was detected in children of all study groups. The results of functional tests and quantitative integrative indicators showed significantly increased autonomic reactivity with depletion of adaptive potential in all study groups (p<0.05). Children with vasovagal syncope had excessive levels more often (p<0.05), and children with syncope due to orthostatic hypotension had insufficient levels of autonomic support (p<0.05). Violations of cardiorespiratory inter systemic connections were found in children with vasovagal and cardiogenic syncope significantly more often, compared to the control group (p <0.05). Correlations were found between the parameters of the initial autonomic balance, autonomic support of the circulatory system, and the manifestations of syncope in children. Conclusions. The correlation between pathological types of autonomic response and the frequency and duration of syncopal episode indicates a pathogenetic relationship between the state of autonomic support and the ability of the circulatory system to respond to triggers. Therefore, indicators of the autonomic homeostasis and adaptive potential can be applied for predicting the occurrence of syncopal episodes and monitoring of effective management of syncope in children. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: children, syncope, autonomic nervous system homeostasis, adaptive potential.

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Advance in the understanding of vasovagal syncope in children and adolescents

Cited by 25 publications

References 30 publications

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope and Falls in Workers

Association of Occupational Distress and Low Sleep Quality with Syncope, Presyncope and Falls in Workers

Prognostic Value of Biomarkers in Children and Adolescents With Orthostatic Intolerance

The features of autonomic nervous system homeostasis and adaptive potential in children with syncope

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