Advance in Stress for Depressive Disorder

Ding, Yu; Dai, Jinxia

doi:10.1007/978-981-32-9271-0_8

Cited by 60 publications

(33 citation statements)

References 269 publications

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“…The over-activation of the HPA axis effectors glucocorticoids and GR causes stress-related gene expression and exhibit different behaviors (De Kloet et al 1998;Herman et al 2016). In addition to the over-activation of the HPA axis, stress-related gene dysfunction increased the susceptibility in response to environmental stress such as the polymorphism of SERT, BDNF, GR, FKBP5, and CRHR1 genes (Ding and Dai 2019). Environmental stress can alter the epigenetics of these genes through different mechanisms such as DNA methylation, chromatin modification, and histone deacetylation, and causes the transcriptional changes of these gene expression, resulting in stress-related disorders (Cheng et al 2018;Prasad et al 2019;Ryan et al 2016).…”

Section: Possible Mechanisms Of Psychiatric Symptomsmentioning

confidence: 99%

Involvement of the Nervous System in SARS-CoV-2 Infection

2020

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As a severe and highly contagious infectious disease, coronavirus disease 2019 (COVID-19) has caused a global pandemic. Several case reports have demonstrated that the respiratory system is the main target in patients with COVID-19, but the disease is not limited to the respiratory system. Case analysis indicated that the nervous system can be invaded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and that 36.4% of COVID-19 patients had neurological symptoms. Importantly, the involvement of the CNS may be associated with poor prognosis and disease worsening. Here, we discussed the symptoms and evidence of nervous system involvement (directly and indirectly) caused by SARS-CoV-2 infection and possible mechanisms. CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients.

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Section: Possible Mechanisms Of Psychiatric Symptomsmentioning

confidence: 99%

Involvement of the Nervous System in SARS-CoV-2 Infection

2020

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“…Among non-smokers, the “school” group had the highest OR for depression in male students and the “both” group had the highest OR for depression in female students. This may indicate that male students are more stressed by SHSE at school than at home, which could be connected to their depressive symptoms [ 34 ]. In addition, male students could be more easily influenced by their friends than female students [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Association Between the Location of Secondhand Smoke Exposure and Depressive Symptoms among South Korean Adolescents

Jang

Jeong

Kang

et al. 2020

IJERPH

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The incidence of depression among adolescents has gradually increased, leading to adult psychological outcomes and suicide. Although the rate of secondhand smoke exposure (SHSE) has recently decreased, SHSE remains high in children. We aimed to determine the association between depressive symptoms in adolescents and the locations of SHSE using an extensive population survey. Using data from the 14th Korea Youth Risk Behavior Web-based Survey, we assessed self-reported data of depressive symptoms and SHSE among non-smokers. SHSE locations were classified into four groups: only at school, only at home, at both school and home, and other places. Multiple logistic regression analysis was performed to identify the associations between SHSE locations and depressive symptoms. The relationship between SHSE and depressive symptoms was the highest in the “SHSE at home and school” group (boys: odds ratio [OR] = 1.61, 95% confidence interval [CI] = 1.44–1.80; girls: OR = 1.72, 95% CI = 1.54–1.91), followed by the “school” (boys: OR = 1.53, 95% CI = 1.39–1.67; girls: OR = 1.36, 95% CI = 1.25–1.48) and “home” groups (boys: OR = 1.23, 95% CI = 1.12–1.35; girls: OR = 1.30, 95% CI = 1.20–1.40). These results emphasize the importance of stricter smoking regulations not only in public places, but also in households. Adolescents and their families should be educated on the dangers of smoking and the effects of SHSE on mental health.

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“…The association between early life stress and depression is controlled by genetic risk factors, including serotonin transporter, brain derived neurotrophic factor, glucocorticoid receptor, FK506-binding protein 5 and corticotropin releasing hormone receptor 1 polymorphisms. At the same time, early life pressures will make epigenetic modifications to these risk genes through DNA methylation and miRNA regulation, which will have long-term effects on the expression of these genes, and cause changes in brain structure and function, and eventually increase Genetic susceptibility (Ding and Dai, 2019).…”

Section: Changes Caused By Early Life Stressmentioning

confidence: 99%

“…Since the etiology of MDD includes the interaction between genes and the environment, epigenetics is important for predicting utility and treatment monitoring (Webb et al, 2020). Stressful life experiences, especially early life stress, might carry out epigenetic modification of these risk genes via DNA methylation and microRNAs (miRNAs) regulation, and the expression of these genes will have long-lasting effects, which will lead to changes in brain structure and function (Pishva et al, 2017;Ding and Dai, 2019). In addition, the epigenetic differences may affect treatment response (Webb et al, 2020), however, the epigenetic mechanism of antidepressant drugs is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Early Life Stress Induced DNA Methylation of Monoamine Oxidases Leads to Depressive-Like Behavior

Jiang

et al. 2020

Front. Cell Dev. Biol.

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Major depressive disorder (MDD) is coming to be the regarded as one of the leading causes for human disabilities. Due to its complicated pathological process, the etiology is still unclear and the treatment is still targeting at the monoamine neurotransmitters. Early life stress has been known as a major cause for MDD, but how early life stress affects adult monoaminergic activity is not clear either. Recently, DNA methylation is considered to be the key mechanism of epigenetics and might play a role in early life stress induced mental illness. DNA methylation is an enzymatic covalent modification of DNA, has been one of the main epigenetic mechanisms investigated. The metabolic enzyme for the monoamine neurotransmitters, monoamine oxidases A/B (MAO A/MAO B) are the prime candidates for the investigation into the role of DNA methylation in mental disorders. In this review, we will review recent advances about the structure and physiological function of monoamine oxidases (MAO), brief narrative other factors include stress induced changes, early life stress, perinatal depression (PD) relationship with other epigenetic changes, such as DNA methylation, microRNA (miRNA). This review will shed light on the epigenetic changes involved in MDD, which may provide potential targets for future therapeutics in depression pathogenesis.

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Advance in Stress for Depressive Disorder

Cited by 60 publications

References 269 publications

Involvement of the Nervous System in SARS-CoV-2 Infection

Involvement of the Nervous System in SARS-CoV-2 Infection

Association Between the Location of Secondhand Smoke Exposure and Depressive Symptoms among South Korean Adolescents

Early Life Stress Induced DNA Methylation of Monoamine Oxidases Leads to Depressive-Like Behavior

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