Adults with Mood Disorders Have an Increased Risk Profile for Cardiovascular Disease within the First 2 Years of Treatment

Taylor, Valerie H.; McKinnon, Margaret C.; MacDonald, Kathryn; Jaswal, Gurpreet; MacQueen, Glenda

doi:10.1177/070674371005500605

Cited by 26 publications

(24 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a Finnish study, the prevalence of MetS in depressed patients was 36% (30). CVD-risk in a sample of people with major depressive disorder or bipolar disorder increased with 50% from pre-treatment to 2-year follow-up (31). …”

Section: Possible Causes Of Increased Risk For Cvd-related Deaths In mentioning

confidence: 99%

Increased Mortality in Schizophrenia Due to Cardiovascular Disease â€“ A Non-Systematic Review of Epidemiology, Possible Causes, and Interventions

et al. 2014

View full text Add to dashboard Cite

Background: Schizophrenia is among the major causes of disability worldwide and the mortality from cardiovascular disease (CVD) is significantly elevated. There is a growing concern that this health challenge is not fully understood and efficiently addressed.Methods: Non-systematic review using searches in PubMed on relevant topics as well as selection of references based on the authors’ experience from clinical work and research in the field.Results: In most countries, the standardized mortality rate in schizophrenia is about 2.5, leading to a reduction in life expectancy between 15 and 20 years. A major contributor of the increased mortality is due to CVD, with CVD mortality ranging from 40 to 50% in most studies. Important causal factors are related to lifestyle, including poor diet, lack of physical activity, smoking, and substance abuse. Recent findings suggest that there are overlapping pathophysiology and genetics between schizophrenia and CVD-risk factors, further increasing the liability to CVD in schizophrenia. Many pharmacological agents used for treating psychotic disorders have side effects augmenting CVD risk. Although several CVD-risk factors can be effectively prevented and treated, the provision of somatic health services to people with schizophrenia seems inadequate. Further, there is a sparseness of studies investigating the effects of lifestyle interventions in schizophrenia, and there is little knowledge about effective programs targeting physical health in this population.Discussion: The risk for CVD and CVD-related deaths in people with schizophrenia is increased, but the underlying mechanisms are not fully known. Coordinated interventions in different health care settings could probably reduce the risk. There is an urgent need to develop and implement effective programs to increase life expectancy in schizophrenia, and we argue that mental health workers should be more involved in this important task.

show abstract

Section: Possible Causes Of Increased Risk For Cvd-related Deaths In mentioning

confidence: 99%

Increased Mortality in Schizophrenia Due to Cardiovascular Disease â€“ A Non-Systematic Review of Epidemiology, Possible Causes, and Interventions

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Globalmente la impresión es que todos estos factores se relacionan de forma indirecta con la existencia de un deterioro orgánico: La prescripción de antidepresivos podría indicar la presencia de síntomas que encubrirían un deterioro cognitivo latente e incluso que estos síntomas depresivos favorecieran otros problemas orgánicos 19 , el ser pensionista indicaría un menor grado de autonomía física y cognitiva y la mala evolución durante el ingreso sería el resultado de una menor capacidad mental para entender su enfermedad y modificar sus hábitos.…”

Section: Factores Que Influyen En La Mortalidadunclassified

Alcohólicos ingresados en una sala de psiquiatría: mortalidad a los 14 años

Monràs

Ortega

2011

Adicciones

View full text Add to dashboard Cite

Introduction: Alcoholic patients show a high mortality rate. We know about the increased mortality of outpatients following specialized treatment for alcohol abuse and inpatients with organic diseases related to alcohol, but it is not clear whether alcoholics with a comorbid psychiatric profile also die prematurely. Objective: To investigate clinical characteristics, therapeutic evolution, survival, and factors that can better predict mortality. Materials: 14-year longitudinal monitoring of 91 patients hospitalized in 1993 for detoxification in a psychiatric unit and who subsequently received outpatient treatment. Results: Patients show a high prevalence of psychiatric disorders (40.6%) and multiple periods of previous treatment (78%). After 14 years the mortality rate was 34.1%.Deceased patients more often presented cognitive decline and were more often on pensions. They were also taking more antidepressants, had less family support and were more likely to have relapsed into alcohol use. Discussion: Many of the factors that predict higher mortality are age-related. In younger patients, the presence of neuropsychological deterioration symptoms may indicate a premature organic disorder and probably greater risk of treatment failure, poor physical care and traumatic physical and mental situations, all of which would also increase the likelihood of premature mortality.Key words: alcoholism, mortality, hospitalization, dual diagnosis. RESUMEN ABSTRACTIntroducción: Los pacientes alcohólicos presentan una elevada mortalidad. Se conoce la de los pacientes que siguen un tratamiento ambulatorio especializado y la de los que ingresan por patologías orgánicas relacionadas con su abuso de alcohol, pero desconocemos si los alcohólicos con un perfil más psiquiátrico también fallecen de forma prematura. Objetivo: investigar las características clínicas, evolución terapéutica, supervivencia y los factores que pueden predecir mejor su mortalidad posterior. Material: Seguimiento longitudinal a los 14 años de una cohorte de 91 pacientes alcohólicos ingresados en 1993 para desintoxicación en una Sala de Psiquiatría y que siguieron tratamiento ambulatorio posterior. Resultados: Presentan una elevada presencia de patología psiquiátrica (40,6%) y múltiples antecedentes de tratamiento (78%). A los 14 años la mortalidad ha sido del 34,1%. Los pacientes fallecidos presentaban con más frecuencia deterioro cognitivo y situación de pensionistas. También recibían antidepresivos más a menudo, tenían menor soporte familiar y habían recaído más en el consumo de alcohol. Discusión: Muchos factores que predicen mayor mortalidad tienen relación con una mayor edad. En los pacientes más jóvenes la presencia de síntomas de deterioro neuropsicológico podría señalar una alteración orgánica prematura y probablemente un mayor riesgo de incumplimiento de tratamientos, mal cuidado físico y situaciones traumáticas, físicas y mentales, todo lo cual favorecería también la mortalidad prematura.

show abstract

“…Importantly, this is not simply attributed to psychiatric morbidity, and, in fact, MDD has been linked to a host of physical illnesses, mitigated in large extent by side effects of pharmacotherapy [9]. Recent evidence highlights the fact that impaired bone health may soon be joining this growing list.…”

Section: Introductionmentioning

confidence: 99%

Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density?

Chau

Atkinson

Taylor

2012

Journal of Osteoporosis

View full text Add to dashboard Cite

Background. Osteoporosis is a chronic disease that can significantly impact numerous aspects of health and wellness. The individual consequences of osteoporosis can be devastating, often resulting in substantial loss of independence and sometimes death. One of the few illnesses with greater disease burden than low bone mineral density (BMD) is major depressive disorder (MDD). Both depression and antidepressant use have been identified as secondary causes of osteoporosis. The objective of this paper is to review and summarize the current findings on the relationship between antidepressant use and BMD. Methods. Relevant sources were identified from the Pubmed and MEDLINE databases, citing articles from the first relevant publication to September 1st, 2010. Results. 2001 articles initially met the search criteria, and 35 studies were thoroughly reviewed for evidence of an association between SSRI use and BMD, and 8 clinical studies were detailed and summarized in this paper. Conclusions. Current findings suggest a link between mental illness and osteoporosis that is of clinical relevance. Additional longitudinal studies and further research on possible mechanisms surrounding the association between SSRI use on bone metabolism need to be conducted. Treatment algorithms need to recognize this association to ensure that vulnerable populations are screened.

show abstract

Adults with Mood Disorders Have an Increased Risk Profile for Cardiovascular Disease within the First 2 Years of Treatment

Abstract: Prior to treatment, MeS and CHD risk rates for patients were similar to the general population, but their risk of CHD increased appreciably.

Cited by 26 publications

References 38 publications

Increased Mortality in Schizophrenia Due to Cardiovascular Disease â€“ A Non-Systematic Review of Epidemiology, Possible Causes, and Interventions

Increased Mortality in Schizophrenia Due to Cardiovascular Disease â€“ A Non-Systematic Review of Epidemiology, Possible Causes, and Interventions

Alcohólicos ingresados en una sala de psiquiatría: mortalidad a los 14 años

Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density?

Contact Info

Product

Resources

About