Adult Xp11 Translocation Associated Renal Cell Carcinoma: Time to Recognize

Renal Cell Carcinoma Associated with Xp11.2 Translocation/ TFE3 gene fusions: clinical experience and literature review

“…The TNM staging was based on the 6th American Joint Committee on Cancer (AJCC) staging criteria, 2002. All the patients were followed up after discharge with contrasted enhanced ultrasonography or CT every 3 months till the time of death or loss of follow-up [22].…”

Xp11.2 translocation renal cell carcinoma with multiple bone metastases: A case report

“…Prior to the development of radical nephrectomy there was no effective surveillance method for Xp11.2 translocation RCC. Klaassen et al (13) recommended aggressive follow-up with regular physical examination, laboratory tests, and chest and abdominal CT, for up to 10 years duration. Furthermore, since Xp11.2 translocation RCC is often diagnosed in young adults, the study proposed lifelong follow-up with a yearly physical examination, laboratory tests, and chest and abdominal imaging subsequent to the completion of the 10-year follow-up.…”

Renal Cell Carcinoma Associated with Xp11.2 Translocation/Transcription Factor E3 (TFE3) Fusion

“…It is estimated that approximately one third of pediatric renal carcinomas are TFE3-related translocation carcinomas [3]. Recent studies have shown that adult Xp11 TRCC is more common than originally perceived, making up anywhere from 1.6% to 5% of adult RCCs [13].…”

“…The most sensitive and specific immunohistochemical markers for these neoplasms bearing TFE3 gene fusion are TFE3 protein and cathepsin-K (Figure 2) [3, 5,6,10,11,[13][14][15][16][17][18][19][21][22][23]. Strong expression of CD10, RCC, E-cadherin, and alpha-methylacyl coenzyme A racemase (AMACR) is common.…”

“…de Jong et al [1] and Tomlinson et al [2] first described Xp11 translocation as a previously unknown finding in the karyotype of two atypical renal masses presenting in infant males [13].…”