Adult-type granulosa cell tumor of the testis: report of a case and review of literature

Abstract

Granulosa cell tumors is classified into juvenile and adult types and comprise less than 5% of ovarian tumors in women and are much rarer in men which only 45 have been previously reported. We report here a 40-year young man with a left testicular adult type granulosa cell tumor. The tumor measured 5.5X5X4cm; Immunohistochemical stains showed the tumor diffusely positive for inhibin and vimentin. Post operative CT scans shows a lomboaortic lymphnodes treated by four cycles of chemotherapy type BEP (bleomycin, etoposide, cisplatin). The thoraco abdominal CT scans post chemotherapy shows the disappearance of the right testicular nodule and the lomboaortic lymphnodes. 2 years after treatment, the patient is alive and well with no signs of recurrence. Our report highlights one more case of this very rare tumor of the testis, which is quite problematic In terms of prognosis and management, and for this reason seems to have attracted the interest of many researchers recently.

Risk factors and treatment outcomes of 239 patients with testicular granulosa cell tumors: a systematic review of published case series data

“…Patient #2 and #3 showed metastatic disease in the RPLN at initial staging were treated with RPLND and remained without evidence of disease during a total follow-up time of 32 (Mohapatra et al 2016 ) and 168 months (Matoska et al 1992 ), respectively. Patient #4 with metastatic disease in the RPLN received four cycles of BEP and remained disease free for at least 6 months (Elbachiri et al 2017 ). Patient #5 presented with lung metastases at initial staging, received 6 cycles of BEP and showed no evidence of disease for at least 13 months (Hammerich et al 2008 ).…”

Adult‐type granulosa cell tumor: An unusual testicular tumor

“…The malignant behavior of this rare entity is usually associated with unfavorable pathological features such as size >5 cm, presence of necrosis, >5 mitosis per 10 high power fields, marked nuclear atypia, lymphovascular invasion, extratesticular involvement, and gynecomastia. The most common sites of metastases include retroperitoneal lymph nodes, and the less common sites include liver, bones, and the lungs 6,8,9 . Our patient only had one of these pathological features specifically the size greater than 5 cm.…”

A rare cause of precocious puberty: Juvenile granulosa cell tumor

“…The median time to relapse is approximately four to six years after initial diagnosis [14]. Tumor markers such as inhibin can also be used to asses for recurrence [15].…”