Adult T-cell leukemia presenting with acute liver failure

Powell, Nick; Rusli, Ferry; Hübscher, Stefan G.; Karanth, Mamatha; Mutimer, David

doi:10.1016/j.leukres.2005.12.026

Cited by 7 publications

(13 citation statements)

References 10 publications

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“…ATLL with blast crisis can be associated with acute liver failure (Kawamura et al 2006;Powell et al 2006). In this severe clinical situation, liver biopsy revealed massive infiltration with atypical T cells characteristic of ATLL and hepatic necrosis (Powell et al 2006). It can be surmised that, similar to other situations with massive leukemic liver infiltration, dense accumulation of tumor cells in sinusoids and portal tracts can critically compromise portal venous inflow and hepatic sinusoidal microcirculation.…”

Section: Liver Involvementmentioning

confidence: 89%

“…As ATLL is a generalized neoplastic disease, the liver is often involved (Hoshi et al 1988;Taniguchi et al 1993;Yamada et al 1997;Tong et al 2004;Kawamura et al 2006;Powell et al 2006;Takasaki et al 2007). In ATLL, hepatic involvement is more frequent than in other lymphomas.…”

Section: Liver Involvementmentioning

confidence: 99%

“…Hepatic infiltration is usually diffuse or multifocal, but a metastatic pattern also occurs (Tong et al 2004). ATLL with blast crisis can be associated with acute liver failure (Kawamura et al 2006;Powell et al 2006). In this severe clinical situation, liver biopsy revealed massive infiltration with atypical T cells characteristic of ATLL and hepatic necrosis (Powell et al 2006).…”

Section: Liver Involvementmentioning

confidence: 99%

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T-Cell Non-Hodgkin’s Lymphomas

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Several types of T-cell non-Hodgkin's lymphomas are characterized by liver involvement, usually in the context of generalized lymphoma disease. The aggressive neoplasm, T-cell prolymphocytic leukemia, showing a proliferation of small-to medium-sized T cells, results in massive bone marrow infiltration and marrow failure but also infiltrates the lymph nodes, liver, and spleen. Hepatic infiltrates mostly involve portal tracts, causing hepatomegaly. Hepatic involvement is a common feature of T-cell large granular lymphocytic leukemia. Liver infiltration is also known for aggressive NK cell leukemia, a systemic proliferation of NK cells almost always associated with EBV infection. The liver may be densely infiltrated by large granular lymphocytes with azurophilic granules. The generalized neoplastic T-lymphocyte process, adult T-cell leukemia/lymphoma, is frequently complicated by focal t diffuse parenchymal or portal tract infiltration of the liver. Other T-cell neoplasms variably involving the liver comprise nasal-type extranodal NK/T-cell lymphoma, hepatosplenic T-cell lymphoma, mycosis fungoides, Sézary syndrome, and peripheral T-cell lymphomas. T-Cell Prolymphocytic Leukemia ICD-O Code 9834/3 T-Cell Large Granular Lymphocytic Leukemia ICD-O Code 9831/3 T-cell receptor genes are in germline configuration and, therefore cannot be employed for clonality assessment. A part of the cases reveal clonal del (6)(q21q25) and 11q deletion.

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Section: Liver Involvementmentioning

confidence: 89%

Section: Liver Involvementmentioning

confidence: 99%

Section: Liver Involvementmentioning

confidence: 99%

See 1 more Smart Citation

T-Cell Non-Hodgkin’s Lymphomas

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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“…Although exceedingly rare, hematologic malignancies can cause acute liver failure by massive infiltration of leukemic cells leading to hepatic necrosis. Case reports have described this phenomenon in the setting of ALL, CLL, and adult T‐cell leukemia . In these reported cases, liver transplantation was not pursued because the diagnosis of hematologic malignancy was firmly established up front.…”

Section: Discussionmentioning

confidence: 99%

“…Acute leukemia is an exceedingly rare cause of acute liver failure, although some degree of secondary hepatic involvement is common . There are a few isolated case reports of AML, CLL, and adult T‐cell leukemia leading to acute liver failure . More commonly described is acute liver failure from B‐cell ALL and T‐cell ALL .…”

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confidence: 99%

Liver transplantation in an adolescent with acute liver failure from acute lymphoblastic leukemia

Reddi

Barbas

Castleberry

et al. 2014

Pediatric Transplantation

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The most common identifiable causes of acute liver failure in pediatric patients are infection, drug toxicity, metabolic disease, and autoimmune processes. In many cases, the etiology of acute liver failure cannot be determined. Acute leukemia is an extremely rare cause of acute liver failure, and liver transplantation has traditionally been contraindicated in this setting. We report a case of acute liver failure in a previously healthy 15-yr-old male from pre-B-cell acute lymphoblastic leukemia. He underwent liver transplantation before the diagnosis was established, and has subsequently received chemotherapy for pre-B-cell acute lymphoblastic leukemia. He is currently alive 31 months post-transplantation. The published literature describing acute lymphoblastic leukemia as a cause of acute liver failure is reviewed.

show abstract

T-Cell Non-Hodgkin’s Lymphomas

Zimmermann

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

View full text Add to dashboard Cite

Adult T-cell leukemia presenting with acute liver failure

Cited by 7 publications

References 10 publications

T-Cell Non-Hodgkin’s Lymphomas

T-Cell Non-Hodgkin’s Lymphomas

Liver transplantation in an adolescent with acute liver failure from acute lymphoblastic leukemia

T-Cell Non-Hodgkin’s Lymphomas

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