Adult T-Cell Leukemia/Lymphoma

Graham, Robbie L.; Burch, Micah; Krause, John R.

doi:10.1080/08998280.2014.11929123

Cited by 13 publications

(10 citation statements)

References 17 publications

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“…The laboratory data indicated that serum calcium, LDH, ALT, AST, direct bilirubin, urea, and creatinine levels, and atypical cell count were related to the patients' survival. [43,44,46], thrombocytopenia [18], eosinophilia [48], atypical ATL cell count in peripheral blood [39,44,49], total protein levels [12,37,45], low serum albumin levels [16,50], high blood urea [50], high levels of creatinine [51], and HTLV-1 PVL [17,37]. The reason for the possible difference between the results of the previous studies and our study, might be the different methodology.…”

Section: Discussionmentioning

confidence: 63%

Combination therapy and survival time in Adult T cell Leukemia/Lymphoma (ATLL)

Borojerdi

Rahimi

Ghezeldasht

et al. 2019

Preprint

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Background: The urgent need for the treatment of ATLL has highlighted in 18th-International Conference on Human Retrovirology-HTLV-1 (Tokyo, 2017). Therefore, in this study the median survival times (MST) of routine therapies for ATLL were evaluated in context of laboratory tests . Methods: In a perspective-retrospective cohort study, the efficiencies of therapy regimens, including interferon-alfa and zidovudine (IFN/ZDV), cyclophosphamide, vincristine, doxorubicin, dexamethasone (hyper-CVAD), lenalidomide/ZDV, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) were evaluated in 67 acute ATLL patients. The demographic, clinical, MST, and routine and molecular laboratory data were then collected and analyzed . Results: The MST for acute and lymphoma subjects was 5 and 11 months, respectively, including 5 months (95% CI 3.378 6.622) for IFN/ZDV, 5 months (95% CI 2.067.94) for CVAD, 3months (95% CI 0.009.86) for lenalidomide/ZDV and 11 months (95%CI 8.45913.54) for CHOP regimen. Importantly, patients who received IFN/ZDV and hyper-CVAD therapy, had a better OS (HR, 0.663; 95%CI, 0.540 to 0.814; P=0.0001), compared with the lenalidomide /ZDV alone. The MST for subjects with hypercalcemia was 5 months, and for patients with normal calcium level was 9 months (p=0.017). Conclusions: High expressions of BIM and CERB were more frequent in lymphomatous type, and considering these factors, platelet counts and HTLV-1-proviral load (PVL) might be predictive factors for differentiating acute and chronic types. Low MST was observed in acute and lymphomatous ATLL, even in the combinational chemo-therapeutic regimens. Therefore, it seems that ATLL treatment should be personalized according to the virus-host interactions on survival signaling pathways, the platelet count and calcium level.

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Section: Discussionmentioning

confidence: 63%

Combination therapy and survival time in Adult T cell Leukemia/Lymphoma (ATLL)

Borojerdi

Rahimi

Ghezeldasht

et al. 2019

Preprint

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“…The interesting link between FEZ1 and HOXB4 differential expression in acute myeloid leukemia could lie in the discovery that FEZ1 overexpression caused the phenotype of multilobulated nuclei (also known as flower‐like nuclei) in mammalian cell line . This nuclear phenotype has already been reported to be a marker of myeloid leukemia of M4/5 subtype .…”

Section: Discussionmentioning

confidence: 99%

Fasciculation and elongation zeta‐1 protein (FEZ1) interacts with the retinoic acid receptor and participates in transcriptional regulation of the Hoxb4 gene

et al. 2017

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Fasciculation and elongation zeta‐1 (FEZ1) protein is involved in axon outgrowth and is highly expressed in the brain. It has multiple interaction partners, with functions varying from the regulation of neuronal development and intracellular transport mechanisms to transcription regulation. One of its interactors is retinoic acid receptor (RAR), which is activated by retinoic acid and controls many target genes and physiological process. Based on previous evidence suggesting a possible nuclear role for FEZ1, we wanted to deepen our understanding of this function by addressing the FEZ1–RAR interaction. We performed in vitro binding experiments and assessed the interface of interaction between both proteins. We found that FEZ1–RAR interacted with a similar magnitude as RAR to its responsive element DR5 and that the interaction occurred in the coiled‐coil region of FEZ1 and in the ligand‐binding domain of RAR. Furthermore, cellular experiments were performed in order to confirm the interaction and screen for induced target genes from an 86‐gene panel. The analysis of gene expression showed that only in the presence of retinoic acid did FEZ1 induce hoxb4 gene expression. This finding is consistent with data from the literature showing the hoxb4 gene functionally involved in development and acute myeloid leukemia, as is FEZ1.

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“…The interesting link between FEZ1 and HOXB4 differential expression in acute myeloid leukemia could lie in the discovery that FEZ1 over-expression caused the phenotype of multi lobulated nuclei (also known as flower-like nuclei) in mammalian cell line[64]. This nuclear phenotype has already been reported to be a marker of myeloid leukemia of M4/5 subtype[65,66].…”

Section: Interaction Partners and Functionsmentioning

confidence: 99%

Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity

Teixeira

Alborghetti

Kobarg

2019

WJBC

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Fasciculation and elongation zeta/zygin (FEZ) proteins are a family of hub proteins and share many characteristics like high connectivity in interaction networks, they are involved in several cellular processes, evolve slowly and in general have intrinsically disordered regions. In 1985, unc-76 gene was firstly described and involved in axonal growth in C. elegans , and in 1997 Bloom and Horvitz enrolled also the human homologues genes, FEZ1 and FEZ2 , in this process. While nematodes possess one gene ( unc-76 ), mammalians have one more copy ( FEZ1 and FEZ2 ). Several animal models have been used to study FEZ family functions like: C. elegans, D. melanogaster , R. novergicus and human cells. Complementation assays were performed and demonstrated the function conservation between paralogues. Human FEZ1 protein is more studied followed by UNC-76 and FEZ2 proteins, respectively. While FEZ1 and UNC-76 shared interaction partners, FEZ2 evolved and increased the number of protein-protein interactions (PPI) with cytoplasmatic partners. FEZ proteins are implicated in intracellular transport, acting as bivalent cargo transport adaptors in kinesin-mediated movement. Especially in light of this cellular function, this family of proteins has been involved in several processes like neuronal development, neurological disorders, viral infection and autophagy. However, nuclear functions of FEZ proteins have been explored as well, due to high content of PPI with nuclear proteins, correlating FEZ1 expression to Sox2 and Hoxb4 gene regulation and retinoic acid signaling. These recent findings open new avenue to study FEZ proteins functions and its involvement in already described processes. This review intends to reunite aspects of evolution, structure, interaction partners and function of FEZ proteins and correlate them to physiological and pathological processes.

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Adult T-Cell Leukemia/Lymphoma

Cited by 13 publications

References 17 publications

Combination therapy and survival time in Adult T cell Leukemia/Lymphoma (ATLL)

Combination therapy and survival time in Adult T cell Leukemia/Lymphoma (ATLL)

Fasciculation and elongation zeta‐1 protein (FEZ1) interacts with the retinoic acid receptor and participates in transcriptional regulation of the Hoxb4 gene

Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity

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