Adult Stem Cells in Aging

Trivanović, Drenka

doi:10.3390/jpm12050795

Cited by 1 publication

(1 citation statement)

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“…Organ formation in the embryos of these organisms requires the presence of tissue-specific stem cells, which later give rise to the organ-specific cell hierarchy driven by growth and patterning signals [ 15 , 24 ]. In the adult stages, organ architecture and functionality are maintained by somatic stem cells, which are found in low frequencies in most adult tissues [ 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: The Emergence Of Tissue-specific Stem Cellsmentioning

confidence: 99%

Stemming Tumoral Growth: A Matter of Grotesque Organogenesis

Merino

García‐Sanz

2023

Cells

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The earliest metazoans probably evolved from single-celled organisms which found the colonial system to be a beneficial organization. Over the course of their evolution, these primary colonial organisms increased in size, and division of labour among the cells became a remarkable feature, leading to a higher level of organization: the biological organs. Primitive metazoans were the first organisms in evolution to show organ-type structures, which set the grounds for complex organs to evolve. Throughout evolution, and concomitant with organogenesis, is the appearance of tissue-specific stem cells. Tissue-specific stem cells gave rise to multicellular living systems with distinct organs which perform specific physiological functions. This setting is a constructive role of evolution; however, rebel cells can take over the molecular mechanisms for other purposes: nowadays we know that cancer stem cells, which generate aberrant organ-like structures, are at the top of a hierarchy. Furthermore, cancer stem cells are the root of metastasis, therapy resistance, and relapse. At present, most therapeutic drugs are unable to target cancer stem cells and therefore, treatment becomes a challenging issue. We expect that future research will uncover the mechanistic “forces” driving organ growth, paving the way to the implementation of new strategies to impair human tumorigenesis.

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