Adult stem cells derived from skeletal muscle — biology and potential

Abstract

Skeletal muscle contains at least two distinct populations of adult stem cells — satellite cells and multipotent muscle-derived stem cells. Monopotential satellite cells are located under the basal lamina of muscle fibers. They are capable of giving rise only to cells of myogenic lineage, which play an important role in the processes of muscle regeneration. Multipotent muscle-derived stem cells are considered to be predecessors of the satellite cells. Under proper conditions, both in vitro and in vivo, they undergo myogenic, cardiogenic, chondrogenic, osteogenic and adipogenic differentiation. The main purpose of the present article is to summarize current information about adult stem cells derived from skeletal muscle, and to discuss their isolation and in vitro expansion techniques, biological properties, as well as their potential for regenerative medicine.

Transplantation of human skeletal muscle-derived progenitor cells ameliorates knee osteoarthritis in streptozotocin-induced diabetic mice

“…Skeletal muscle can regenerate new muscle fibers, when it has been injured or as a consequence of diseases . Muscle regeneration mainly depends on satellite/stem/progenitor cells, which localized between the basal lamina and the muscle fiber membrane . Several animal studies and clinical trials have been reported to investigate the therapeutic potential of intramuscular injection of normal skeletal myoblasts on Duchenne muscular dystrophy; however, there were some problems to affect the results, including the low survival and migration of donor cells and rejection of the donor cells .…”