Adult Stem Cells Based Therapies in Veterinary Medicine

Vikartovska, Zuzana; Humeník, Filip; Maloveská, Marcela; Farbáková, Jana; Hornakova, Lubica; Murgoci, Adriana-Natalia; Čı́žková, Dáša

doi:10.26502/avsm.014

Cited by 4 publications

(9 citation statements)

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“…MSCs’ therapeutic function is based on their ability to differentiate into cells that need to be replaced, as well as their immunomodulatory and paracrine activities, also their antioxidant effect which aid in the healing of diverse tissue [ 53 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

“…Multipotent have ability to differentiate into a related family of cells as adult stem cells that can become red and white blood cells or platelets. Unipotent have the ability to only produce cells of their own type as (adult) muscle stem cells [ 9 , 53 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

“…Prządka, Buczak [ 9 ], Vikartovska, Humenik [ 53 ], and Kalra and Tomar [ 54 ] added other classifications according to the source of stem cells into two types: early or embryonic stem cells (ESCs) which is found in the inner blastocyst cell mass and adult stem cells (ASCs) which is found in adult body tissues.…”

Section: Resultsmentioning

confidence: 99%

“…Roushandeh, Bahadori [ 57 ] mentioned that MSCs are type of multipotent stem cells isolated from tissues as bone marrow, fat, and amniotic membrane. [ 42 , 53 , 58 , 59 ] observed that mesenchymal stem cells are characterized by specific surface antigen expression and their osteogenic, chondrogenic, and adipogenic differentiation ability and had the facility to self-renew.…”

Section: Resultsmentioning

confidence: 99%

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Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals

et al. 2023

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Infertility is a serious medical, economic, and psychological problem in the society. Male factor infertility, due to defective spermatogenesis as a result of a failure in germ cell proliferation and differentiation, appears to be the cause of 25–50% of infertility cases. According to several surveys, testicular degeneration can be caused by a variety of physical, chemical, and microbial causes. A stem cell is a non-specialized cell which is characterized by self-renewal by mitotic cell division and able to differentiate to specialized cells for the various tissues of the body. The data were obtained and analyzed from different databases (PubMed, Google Scholar, Egyptian Knowledge Bank, Elsevier, Medline, Embase, ProQuest, and BMC). This review discusses the causes, symptoms, and grades of testicular degeneration and the use of different types of stem cells in regeneration. And its conclusion based on previous researches and trials, MSCs are considered effective therapy for testicular degeneration.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals

et al. 2023

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“…Even if this kind of therapy still needs to be more extensively investigated, in the future stem cells may be an alternative treatment in some cases for which the conventional medicines cannot repair the damages tissues. MSCs have differentiation potential but also immune regulatory properties, influence on vascularization, apoptosis, fibrosis and inflammation [7][8][9]. Regenerative cell therapy is used in degenerative diseases (heart failure), immune mediated diseases (feline asthma, canine atopic dermatitis, feline chronic gingivostomatitis) [10], inflammatory diseases (wound healing defect).…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Cat Olfactory Ecto-Mesenchymal Stem Cells

Mollichella

Mechin

Royer³

et al. 2022

Animals

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The olfactory mucosa contains olfactory ecto-mesenchymal stem cells (OE-MSCs) which show stemness features, multipotency capabilities, and have a therapeutic potential. The OE-MSCs have already been collected and isolated from various mammals. The aim of this study was to evaluate the feasibility of collecting, purifying and amplifying OE-MSCs from the cat nasal cavity. Four cats were included in the study. Biopsies of olfactory mucosa were performed on anesthetized animals. Then, the olfactory OE-MSCs were isolated, and their stemness features as well as their mesodermal differentiation capabilities were characterized. Olfactory mucosa biopsies were successfully performed in all subjects. From these biopsies, cellular populations were rapidly generated, presenting various stemness features, such as a fibroblast-like morphology, nestin and MAP2 expression, and sphere and colony formation. These cells could differentiate into neural and mesodermal lineages. This report shows for the first time that the isolation of OE-MSCs from cat olfactory mucosa is possible. These cells showed stemness features and multilineage differentiation capabilities, indicating they may be a promising tool for autologous grafts and feline regenerative medicine.

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Using carbohydrate‐based polymers to facilitate testicular regeneration

Majeed,

Afzal,

Maqsood

et al. 2024

Biology of the Cell

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Male infertility is a significant global issue affecting 60–80 million people, with 40%–50% of cases linked to male issues. Exposure to radiation, drugs, sickness, the environment, and oxidative stress may result in testicular degeneration. Carbohydrate‐based polymers (CBPs) restore testis differentiation and downregulate apoptosis genes. CBP has biodegradability, low cost, and wide availability, but is at risk of contamination and variations. CBP shows promise in wound healing, but more research is required before implementation in healthcare. Herein, we discuss the recent advances in engineering applications of CBP employed as scaffolds, drug delivery systems, immunomodulation, and stem cell therapy for testicular regeneration. Moreover, we emphasize the promising challenges warranted for future perspectives.

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Adult Stem Cells Based Therapies in Veterinary Medicine

Cited by 4 publications

References 0 publications

Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals

Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals

Isolation and Characterization of Cat Olfactory Ecto-Mesenchymal Stem Cells

Using carbohydrate‐based polymers to facilitate testicular regeneration

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