Adult stem cells and regenerative medicine—a symposium report

Cable, Jennifer; Fuchs, Elaine; Weissman, Irving L.; Jasper, Heinrich; Glass, David J.; Rando, Thomas A.; Blau, Helen M.; Debnath, Shawon; Oliva, Anthony A.; Park, Sang‐Bum; Passegué, Emmanuelle; Kim, Carla F.; Krasnow, Mark A.

doi:10.1111/nyas.14243

Cited by 50 publications

(33 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adult stem/progenitor cells are a small population of cells that reside in tissue-specific niches and possess the potential to differentiate in all the cell types of the organ in which they operate. Adult stem cells (e.g., hematopoietic stem cells, intestinal stem cells, satellite cells, skin stem cells, and germline stem cells) are implicated with the homeostasis, regeneration, and aging of practically all tissues [ 14 , 15 , 16 , 17 , 18 , 19 ]. Adult stem cell regenerative function declines with age, and cell-autonomous and non-autonomous modifications within in the niche, as well as in the circulating blood, are involved in this age-related decline [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease

Cianflone

Torella

Biamonte

et al. 2020

Cells

View full text Add to dashboard Cite

Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and possess the potential to differentiate in all cell types of the organ in which they operate. Adult stem cells are implicated with the homeostasis, regeneration, and aging of all tissues. Tissue-specific adult stem cell senescence has emerged as an attractive theory for the decline in mammalian tissue and organ function during aging. Cardiac aging, in particular, manifests as functional tissue degeneration that leads to heart failure. Adult cardiac stem/progenitor cell (CSC) senescence has been accordingly associated with physiological and pathological processes encompassing both non-age and age-related decline in cardiac tissue repair and organ dysfunction and disease. Senescence is a highly active and dynamic cell process with a first classical hallmark represented by its replicative limit, which is the establishment of a stable growth arrest over time that is mainly secondary to DNA damage and reactive oxygen species (ROS) accumulation elicited by different intrinsic stimuli (like metabolism), as well as external stimuli and age. Replicative senescence is mainly executed by telomere shortening, the activation of the p53/p16INK4/Rb molecular pathways, and chromatin remodeling. In addition, senescent cells produce and secrete a complex mixture of molecules, commonly known as the senescence-associated secretory phenotype (SASP), that regulate most of their non-cell-autonomous effects. In this review, we discuss the molecular and cellular mechanisms regulating different characteristics of the senescence phenotype and their consequences for adult CSCs in particular. Because senescent cells contribute to the outcome of a variety of cardiac diseases, including age-related and unrelated cardiac diseases like diabetic cardiomyopathy and anthracycline cardiotoxicity, therapies that target senescent cell clearance are actively being explored. Moreover, the further understanding of the reversibility of the senescence phenotype will help to develop novel rational therapeutic strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease

Cianflone

Torella

Biamonte

et al. 2020

Cells

View full text Add to dashboard Cite

show abstract

“…Therefore, a lot of techniques and strategies can be used to help regenerate skin tissue and accelerate the healing process. [40], [42] However, when the process is disordered, chronic wounds are created, exhibiting persistent inflammation, biofilm development, microorganism recruitment and release of platelet derived factors. Therefore, growth factors are truly important since they are the focal regulatory points of repairment.…”

Section: Phases and Complications Of The Wound Healing Processmentioning

confidence: 99%

The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration

Lopes¹,

Sousa²,

Alvites³

et al. 2021

Preprint

View full text Add to dashboard Cite

In the past decades, regenerative medicine applied on skin lesions has been a field of constant improvement for both human and veterinary medicine. The process of healing cutaneous wound injuries implicates a well-organized cascade of molecular and biological processes. However, sometimes the normal process fails and can result in a chronic lesion. In addition, wounds are considered an increasing clinical impairment, due to the progressive ageing of the population, as well as the prevalence of concomitant diseases, such as diabetes and obesity, that represent risk aggravating factors for the development of chronic skin lesions. Stem cells regenerative potential has been recognized worldwide, including towards skin lesion repair, Tissue engineering techniques have long been successfully associated with stem cell therapies, namely the application of 3D bioprinted scaffolds. With this review we intend to explore several stem cell sources with promising aptitude towards skin regeneration, as well as different techniques used to deliver those cells and provide a supporting extracellular matrix environment, with effective outcomes. Furthermore, different studies are discussed, both in vitro and in vivo, towards their relevance in the skin regeneration field.

show abstract

“…Almost every organ in the adult human body can maintain itself over the long term and undergo repair after injury. These properties are largely dependent on stem cellscells that can both divide repeatedly to make more of themselves (self-renew) and generate daughters that can give rise to one or more differentiated cell type [1]. This Monograph brings together information about the different classes of stem cells present in both the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes.…”

Section: @Erspublicationsmentioning

confidence: 99%

Preface

Hurst¹

2021

Lung Stem Cells in Development, Health and Disease

View full text Add to dashboard Cite

Adult stem cells and regenerative medicine—a symposium report

Cited by 50 publications

References 44 publications

Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease

Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease

The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration

Preface

Contact Info

Product

Resources

About