Adult stem cell response to doped bioactive borate glass

Thyparambil, Nathan J; Gutgesell, Lisa; Hurley, Cassandra C.; Flowers, Lauren E; Day, Delbert E.; Semon, Julie A.

doi:10.1007/s10856-019-6353-4

Cited by 11 publications

(8 citation statements)

References 58 publications

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“… 9 However, some studies show that trace metallic elements are potentially cytotoxic. 51 , 79 High concentrations of boron can have a significant negative impact on the brain and reproductive health. 66 One of the concerns related to the medical use of BBGs is the release of borate ions during degradation of the glass.…”

Section: Properties Of Borate Bioactive Glassesmentioning

confidence: 99%

“…Moreover, the controlled release of boron during degradation of BBGs can improve bone repair, since small concentrations of boron are reported to favor bone growth . However, some studies show that trace metallic elements are potentially cytotoxic. , High concentrations of boron can have a significant negative impact on the brain and reproductive health . One of the concerns related to the medical use of BBGs is the release of borate ions during degradation of the glass .…”

Section: Properties Of Borate Bioactive Glassesmentioning

confidence: 99%

“…Many studies have reported that BBGs could contribute to regenerate bone with no cytoxicity in vivo. ,,, The controlled release of boron during degradation of BBGs can improve bone repair since small concentrations of boron favor osteogenesis . The ion release and degradation rates of 13-93B scaffolds have been reported to trigger bone formation and resorption .…”

Section: Applications Of Bbgsmentioning

confidence: 99%

See 2 more Smart Citations

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Ege

Zheng

Boccaccını

2022

ACS Appl. Bio Mater.

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Since the early 2000s, borate bioactive glasses (BBGs) have been extensively investigated for biomedical applications. The research so far indicates that BBGs frequently exhibit superior bioactivity and bone healing capacity compared to silicate glasses. They are also suitable candidates as drug delivery devices for infection or disease treatment such as osteoporosis. Additionally, BBGs are also an excellent option for wound healing applications, which includes the availability of commercial (FDA approved) microfibrous BBG dressings to treat chronic wounds. By addition of modifying ions, the bone or wound healing capacity of BBGs can be enhanced. For instance, addition of copper ions into BBGs was shown to drastically increase blood vessel formation for wound healing applications. Moreover, addition of ions such as magnesium, strontium, and cobalt improves bone healing. Other recent research interest related to BBGs is focused on nerve and muscle regeneration applications, while cartilage regeneration is also suggested as a potential application field for BBGs. BBGs are commonly produced by melt-quenching; however, sol–gel processing of BBGs is emerging and appears to be a promising alternative. In this review paper, the physical and biological characteristics of BBGs are analyzed based on the available literature, the applications of BBGs are discussed, and future research directions are suggested.

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Section: Properties Of Borate Bioactive Glassesmentioning

confidence: 99%

Section: Properties Of Borate Bioactive Glassesmentioning

confidence: 99%

Section: Applications Of Bbgsmentioning

confidence: 99%

See 1 more Smart Citation

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Ege

Zheng

Boccaccını

2022

ACS Appl. Bio Mater.

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show abstract

“…There are elaborate works on borate-based BGs, which demonstrate that these materials can be employed for in vivo bone repair in the same way, without any cytotoxicity or side effects [ 38 , 73 , 140 , 141 ], since a low amount of boron can promote osteogenesis, while the controlled release of boron ions during degradation hasten the bone repair mechanism [ 73 ]. In addition, it has been discovered that bioactive borate glasses have higher degradation rates, making them more suitable candidates in both hard tissue and soft tissue regeneration than silicate-based ones.…”

Section: Application Possibilities Of Bioactive Glassesmentioning

confidence: 99%

Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area

et al. 2023

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Bioactive glasses (BGs) are especially useful materials in soft and bone tissue engineering and even in dentistry. They can be the solution to many medical problems, and they have a huge role in the healing processes of bone fractures. Interestingly, they can also promote skin regeneration and wound healing. Bioactive glasses are able to attach to the bone tissues and form an apatite layer which further initiates the biomineralization process. The formed intermediate apatite layer makes a connection between the hard tissue and the bioactive glass material which results in faster healing without any complications or side effects. This review paper summarizes the most recent advancement in the preparation of diverse types of BGs, such as silicate-, borate- and phosphate-based bioactive glasses. We discuss their physical, chemical, and mechanical properties detailing how they affect their biological performances. In order to get a deeper insight into the state-of-the-art in this area, we also consider their medical applications, such as bone regeneration, wound care, and dental/bone implant coatings.

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“…Furthermore, boron has a number of key functions inside the biological environment, especially in bone metabolism, thanks to its interaction with calcium, magnesium and vitamin D, and, therefore, its presence is even more crucial for bone preservation and osteoporosis limitation [22,23]. Some studies evidenced that boron influences osteogenic differentiation of mesenchymal stem cells [24,25], being also angiogenic [26]. Many studies report that ion doping enhances the antibacterial properties of borate based bioglass [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Borate and Silicate Bioactive Glass Coatings Prepared by Nanosecond Pulsed Laser Deposition

et al. 2020

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Silicate (13-93) and borate (13-93-B3) bioactive glass coatings were successfully deposited on titanium using the nanosecond Pulsed Laser Deposition technique. The coatings’ microstructural characteristics, compositions and morphologies were examined by a number of physico-chemical techniques. The deposited coatings retain the same functional groups of the targets, are a few microns thick, amorphous, compact and crack free. Their surface is characterized by the presence of micrometric and nanometric particles. The surface topography, investigated by Atomic Force Microscopy, is characterized by spherical or ellipsoidal particles of the 0.2–3 μm size range for the 13-93 silicate bioactive glass film and of the 0.1–1 µm range for the 13-93-B3 borate bioactive glass coating. Equine adipose tissue-derived mesenchymal stem cells (ADMSCs) were applied for biological tests and the osteogenic differentiation activity of cells on the deposited coatings was studied after ADMSCs growth in osteogenic medium and staining with Alizarin Red. Cytocompatibility and osteogenic differentiation tests have shown that thin films retain the biocompatibility properties of the target silicate and borate glass, respectively. On the other hand, no antibacterial activity of the borate glass films was observed, suggesting that ion doping is advisable to inhibit bacterial growth on the surface of borate glass thin films.

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Adult stem cell response to doped bioactive borate glass

Cited by 11 publications

References 58 publications

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area

Borate and Silicate Bioactive Glass Coatings Prepared by Nanosecond Pulsed Laser Deposition

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