Adult rhabdomyosarcoma originating in the temporal muscle, invading the skull and meninges: A case report

Abstract

BACKGROUND Rhabdomyosarcoma (RMS) is a rare malignant tumor of mesenchymal origin that mainly affects children. Spindle cell/sclerosing RMS (SSRMS) is even rarer. It is a new subtype that was added to the World Health Organization disease classification in 2013. To the best of our knowledge, this is the first reported case of adult SSRMS disease classification originating in the temporal muscle. CASE SUMMARY SSRMS originating in the temporal muscle of a male adult enlarged rapidly, destroyed the skull, and invaded the meninges. The tumor was completely removed, and the postoperative pathological diagnosis was SSRMS. Postoperative recovery was good and chemotherapy and radiotherapy were given after the operation. Followed up for 3 mo, no tumor recurred. CONCLUSION RMS is one of the differential diagnoses for head soft tissue tumors with short-term enlargement and skull infiltration. Preoperative computed tomography or magnetic resonance imaging is necessary for early detection of tumor invasion of the skull and brain tissue.

Epithelioid and spindle rhabdomyosarcoma with TFCP2 rearrangement in abdominal wall: a distinctive entity with poor prognosis

“…Whereas, SS-RMS mainly occurs in infants, children, and adults that similar to ES-RMS and has a median age about 24 years, which affects even younger people than E-RMS. But both E-RMS and SS-RMS mainly arises from the head and neck, and extremity [ 10 , 22 – 47 ] (Tables 2 and 3 ).…”

“…Additionally, we found that many cases of ES-RMS had local progression or metastasis, and up to 50% (12/24) of ES-RMS had died of disease within the follow-up times, similar to E-RMS (median survival time is 10 month) [ 22 – 32 ], ES-RMS showed a more aggressive behavior and adverse prognosis (median survival time is 17 month) than SS-RMS (median survival time is 65 month) [ 10 , 12 , 15 – 17 , 19 – 21 , 33 , 34 , 36 – 40 , 42 – 47 ] (Tables 1 , 2 and 3 ; Fig. 5 ).…”