Adult Respiratory Distress Syndrome following Administration of Lidocaine

Howard, John; Mohsenifar, Zab; Simons, Steven M.

doi:10.1378/chest.81.5.644

Cited by 25 publications

(6 citation statements)

References 2 publications

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“…In anti-arrhythmic treatment in adults, lidocaine therapeutic drug levels are between 1.5 and 6 mg/L [2,6], with levels >9 mg/L being associated with toxicity [10,15]. The toxic effects of the drug are mainly exerted on the central nervous system and the cardiovascular system, with a rapid infusion of a large dose possibly resulting in a generalized seizure [13]. Cardiovascular events include bradycardia, hypotension and heart block [13].…”

Section: Introductionmentioning

confidence: 99%

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Development of an optimal lidocaine infusion strategy for neonatal seizures

et al. 2006

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Section: Introductionmentioning

confidence: 99%

“…The toxic effects of the drug are mainly exerted on the central nervous system and the cardiovascular system, with a rapid infusion of a large dose possibly resulting in a generalized seizure [13]. Cardiovascular events include bradycardia, hypotension and heart block [13].…”

Section: Introductionmentioning

confidence: 99%

Development of an optimal lidocaine infusion strategy for neonatal seizures

et al. 2006

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“…Many oxidant substances, including anesthetic agents, can accelerate the formation and dangerously increase the circulating fraction of methemoglobin, which is normally less than 2% of total hemoglobin. 13,14 A similar case of lidocaine-induced adult respiratory distress syndrome (ARDS) was described after subcutaneous administration of lidocaine for suturing a wound. The severity of symptoms and consequences depends on the methemoglobin level, ranging from central cyanosis (>15% of total hemoglobin) to neurologic and cardiac dysfunction (>45%) to death (>70%).…”

Section: Discussionmentioning

confidence: 99%

Acute Respiratory Distress Syndrome After Airway Anesthesia With Lidocaine

Dʼelia¹,

Ghio²

2010

Journal of Bronchology &Amp; Interventional Pulmonology

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Adequate anesthesia of the upper and proximal lower airways is a critical prerequisite for a smooth and successful bronchoscopic procedure. Lidocaine is the most commonly used local anesthetic agent for flexible bronchoscopy. Adverse reactions to this agent have rarely been reported. Nevertheless, we recently observed a life-threatening reaction to airway lidocaine anesthesia in a 33-year-old man who was to undergo flexible bronchoscopy for the evaluation of an intrathoracic lymphadenopathy. Before the procedure, the patient developed noncardiogenic pulmonary edema. Only 2 such cases after airway anesthesia with nontoxic doses of lidocaine for a bronchoscopic procedure have been reported in the literature. Unlike in these cases, the episode was brief and self-limiting, with adverse reaction confined to the respiratory tract without development of shock or systemic involvement.

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“…ARDS is associated with many conditions, all of which have the ability to induce damage to the alveolarcapillary membrane," Included in this list are shock, infection, trauma, inhalation of toxic gases, aspiration, disseminated intravascular coagulation, metabolic disorders, and drugs (Table p. [8][9][10][11][12][13] . The overall incidence ranges from 1-40 percent in various predisposed groups such as septic patients or patients with aspiration.…”

Section: Incidence and Etiologymentioning

confidence: 99%

The Adult Respiratory Distress Syndrome

Boucher¹,

Foster²

1984

Drug Intelligence & Clinical Pharmacy

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The adult respiratory distress syndrome (ARDS) is a common form of acute respiratory failure that has been increasingly reported as associated with a wide variety of medical conditions . Unlike other identifiable pathological events causing severe lung injury, it is now recognized that ARDS is not a single disease, but a complex interaction of pathophysiological events that result in diffuse injury to lung parenchyma.Only through a thorough understanding of ARDS pathophysiology, pathogenesis, and clinical course can medical intervention be instituted in a judicious and timely manner.This review article is intended to provide an overview of the suspected precipitating causes, discrete pathophysiologic changes, and monitorable clinical events associated with ARDS .With mortality from ARDS high, significant attention is being given to improving therapeutic intervention with such conventional measures as mechanical ventilation, positive endexpiratory pressure, and fluid management, along with corticosteroids and several new experimental pharmacologic approaches. Drug Intel/ Clin Pharm 1984;/8: 862-8.

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Adult Respiratory Distress Syndrome following Administration of Lidocaine

Cited by 25 publications

References 2 publications

Development of an optimal lidocaine infusion strategy for neonatal seizures

Development of an optimal lidocaine infusion strategy for neonatal seizures

Acute Respiratory Distress Syndrome After Airway Anesthesia With Lidocaine

The Adult Respiratory Distress Syndrome

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