Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma

Chapman-Fredricks, Jennifer R.; Herrera, Laura Viviana; Bracho, Jorge; Gomez‐Fernandez, Carmen; Leveillee, Raymond J.; Rey, Luís; Jordà, Mercè

doi:10.1016/j.anndiagpath.2011.03.002

Cited by 35 publications

(37 citation statements)

References 10 publications

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“…Gökden et al [3] initially described rhabdoid features in RCCs. The incidence of rhabdoid features was reported in approximately 1.4-7.4% of all RCCs [3,4,5,6,7,8,9]. We reported previously that the biological behavior of RCCs with rhabdoid features is highly aggressive and presents a very poor prognosis [5], which has been confirmed by other investigators [7,8,9,10].…”

Section: Introductionsupporting

confidence: 70%

“…The incidence of rhabdoid features was reported in approximately 1.4-7.4% of all RCCs [3,4,5,6,7,8,9]. We reported previously that the biological behavior of RCCs with rhabdoid features is highly aggressive and presents a very poor prognosis [5], which has been confirmed by other investigators [7,8,9,10]. Rhabdoid features were identified in several RCC histological subtypes, most commonly observed in clear cell RCC (ccRCC) [11], the most conventional histopathological subtype [12].…”

Section: Introductionmentioning

confidence: 99%

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Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

et al. 2016

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Aims: The aims of this study were to investigate the association of renal cell carcinoma (RCC) displaying rhabdoid features and morphologically mesenchymal characteristics with epithelial to mesenchymal transition (EMT), and to clarify the expression of EMT markers. Methods: We investigated the expression of EMT markers (E-cadherin, vimentin, Snail, Slug, ZEB1, ZEB2 and Twist1) using immunohistochemistry, Western blotting and real-time polymerase chain reaction in 18 cases of clear cell RCC (ccRCC) with rhabdoid features and 74 ccRCC cases with Fuhrman grade 1-3 (G1 to G3). Results: In ccRCCs with rhabdoid features, low E-cadherin and high vimentin expression were found. In G1 to G3 ccRCCs, low E-cadherin expression and high expression of vimentin, ZEB1 and ZEB2 were found. There was no significant difference in the immunoexpression of E-cadherin and vimentin between the two ccRCC groups. Conclusions: The rhabdoid features may histologically and biologically be associated with EMT in ccRCC. There is a possibility that in G1 to G3 ccRCCs showing epithelial structures, other cell-cell adhesion mechanisms apart from E-cadherin adhesion may continue to work, and that ccRCC with rhabdoid features may be caused by an inactivation or loss of these mechanisms.

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Section: Introductionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

et al. 2016

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“…The presence of these cells in CCRCC statistically correlated with higher grade and stage [14]. Syncytial cells have been associated with tumour aggressiveness in CCRCC in a very recent study [25], and rhabdoid elements are equivalent to sarcomatoid dedifferentiation in another [26]. Considering the prognostic importance of these histological findings, current sampling protocols in renal carcinomas might not be appropriate.…”

Section: Discussionmentioning

confidence: 89%

Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous

et al. 2014

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Heterogeneity is an inherent event to tumour development that is lately receiving much attention in oncologic research. The topic is being addressed primarily at the molecular level, and results are promising. However, translation to practical medicine is still pending. Our intention in this study is to approach the problem in a series of clear cell renal cell carcinomas with the tools that pathologists use in routine practice. Three randomly selected areas of 48 clear cell renal cell carcinomas prospectively collected in two different institutions were analysed for intratumour heterogeneity. The evaluated parameters were tumour size, cell type (clear vs. eosinophilic), Fuhrman's grade and immunohistochemical expression of carbonic anhydrase IX, BRCA1-associated protein-1 (BAP-1), cyclooxygenase-2 (COX-2) and Ki67. Intratumour heterogeneity was detected in 26 cases (54 %). Cell type, grade and Ki67 index were the parameters more frequently heterogeneous amounting, respectively, 44, 42 and 38 %. Tumour size was a significantly discriminative factor to predict tumour heterogeneity, with a cut-off of 3.8 cm (p < 0.001). Aside from tumour size, the most relevant parameters related with intratumour heterogeneity were cell type (clear vs. eosinophilic), Fuhrman's grade and Ki67 and COX-2 expression patterns. Carbonic anhydrase 9 and BAP-1 did not show statistical relevance. We conclude that heterogeneity is a common event in clear cell renal cell carcinomas that may be overlooked in cases insufficiently sampled. Tumour size appears as a reliable tool in identifying this situation since clear cell renal cell carcinomas under 3.8 cm in diameter are always homogeneous. This point may help the pathologist to make decisions in tumour sampling.

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“…The presence of syncytial cells in CCRCC was also associated with poor prognosis in a subsequent study (13), while earlier, the rhabdoid phenotype was compared in prognostic terms to sarcomatoid transformation (14). Very recent studies confirm the adverse effect of rhabdoid differentiation in the prognosis of CCRCC (15)(16)(17)(18).…”

Section: Morphological Heterogeneitymentioning

confidence: 95%

Intratumor heterogeneity in clear cell renal cell carcinoma: a review for the practicing pathologist

López

2016

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Intertumor heterogeneity, defined as the spectrum of morphological differences found in similar tumors in different patients, is a well-known event for pathologists. However, recent molecular studies have pointed to intratumor heterogeneity as one of the most important issues in human neoplasia in the next years. Clear cell renal cell carcinoma is an example of an intrinsically heterogeneous neoplasm, and some of the most salient advances in the knowledge of intratumor heterogeneity have been developed on it. This review intends to analyze this phenomenon in this tumor from the practicing pathologist's point of view. A careful study of the surgical specimen and an exhaustive tumor sampling are mandatory to keep relevant information. Currently accepted protocols designed for renal tumor sampling may be insufficient. As a result, a different approach to tumor sampling is advisable to ascertain that intratumor heterogeneity, if present, will be well represented in the selected material.

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Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma

Cited by 35 publications

References 10 publications

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous

Intratumor heterogeneity in clear cell renal cell carcinoma: a review for the practicing pathologist

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