Adult Pineal Region Atypical Teratoid Rhabdoid Tumor: A Case for Aggressive Surgical and Chemoradiation Management with Comprehensive Literature Review

Mathkour, Mansour; Carsky, K; Chabot, A. Bert; Werner, Cassidy; Berry, John F.; Carr, Christopher; Lockwood, Joseph; Keen, Joseph R.; Bui, Cuong J.; Biro, Erin

doi:10.1016/j.wneu.2020.06.144

Cited by 7 publications

(7 citation statements)

References 64 publications

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“…It has been reported that the frequency of adult‐onset AT/RT is approximately 1.7% of AT/RT cases. Furthermore, according to a survey by Mathkour et al, 6 only 9 of the 85 adult‐onset AT/RTs occurred in the pineal gland, establishing its rarity.…”

Section: Discussionmentioning

confidence: 99%

“…Atypical teratoid/rhabdoid tumor of the pineal region in adults was first reported in 1999 by Sugita et al 7 as a pineal malignant rhabdoid tumor; thereafter, only nine cases have been reported to date, making our patient 10th in the list (Table 2 ). 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 Considering the radiographic images, adult pineal AT/RT examined by Kanoto et al 15 in 2015 was considered to be the same as the case reported by Kuge et al 11 in 2012; therefore, it was counted as one case. The age of these patients ranged from 19 to 45 years and comprised four men and six women.…”

Section: Discussionmentioning

confidence: 99%

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A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

Doi

Koike

Yoshida

et al. 2021

Pathology International

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A 31‐year‐old man suffered from headaches and presented at a hospital after the symptom worsened. Obstructive hydrocephalus and a pineal tumor were identified, and he was transferred to our hospital for further investigation and treatment. Cranial computed tomography revealed a hypodense mass lesion on the right of the pineal region, and calcifications and enlargement of the lateral and third cerebral ventricles were also evident. Blood tests were negative for all tumor markers. Laparoscopic biopsy and third‐ventricle fenestration were performed that day as an emergency surgery to treat the obstructive hydrocephalus. Postoperative cranial magnetic resonance imaging revealed a solid tumor that was hypointense on T1‐weighted imaging, hyperintense on T2‐weighted imaging, and heterogeneously enhanced by Gd. Subsequently, the tumor increased in size, and craniotomy and tumorectomy were performed. Histologically, the tumor proliferated as round or short spindle‐shaped cells in a myxoid matrix, forming arrays that surrounded the blood vessels. As a few cells with eosinophilic cytoplasm were also present and immunostaining for INI‐1 was negative, the patient was diagnosed with atypical teratoid/rhabdoid tumor (AT/RT). AT/RT of the pineal region in adults is rare, and herein, we report the morphological characteristics of this case and reviewed the relevant literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

Doi

Koike

Yoshida

et al. 2021

Pathology International

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“…By contrast, the most common locations in adults are the cerebral hemisphere and the sellar region ( 2 , 4 , 5 ). The pathological features of AT/RT are peculiar, consisting primarily of rhabdoid cells and heterogeneous portions containing mesenchymal, epithelial, and neuroectodermal cells ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…Using DNA methylation and gene expression profiling, the relevant reports showed that AT/RTs are comprised of three epigenetic subgroups with distinct enhancer landscapes: ATRT-TYR, ATRT-SHH, and ATRT-MYC ( 8 ). AT/RTs are often misdiagnosed as other types of brain tumors due to the lack of specific radiological features and the heterogeneous nature of the tumor cells ( 6 ). Differential diagnoses should be noted for embryonal tumor, medulloblastoma, choroids plexus carcinoma, and high-grade glioma ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the treatment criteria (including stratification criteria) for patients with AT/RT are a controversial topic ( 10 ). The prognosis is grim, even if the treatment generally consists of surgical resection in combination with chemotherapy and radiation therapy (RT) ( 6 ). In order to better diagnose and treat AT/RT, more cases should be included in the study.…”

Section: Introductionmentioning

confidence: 99%

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Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review

et al. 2022

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Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly malignant tumor that mainly occurs in children under the age of 3 and has only been rarely described in adults. The fact that AT/RT patients have such a terrible prognosis is even more regrettable. Herein, we reported two special cases of AT/RT, both of which were under 3 years. Symptoms at presentation included increased intracranial pressure and cerebellar symptoms such as headache, altered gait, and ataxia. As for the tumor location, one was infratentorial in the posterior fossa, and the other was the right lateral ventricle. Preoperative magnetic resonance imaging scans showed calcification and heterogeneous contrast enhancement in the lesions. The mass was excised surgically for the progression of symptoms. Postoperative pathologies of the tumors, combined with immunohistochemistry, revealed AT/RT. AT/RTs are often misdiagnosed as other types of brain tumors due to the lack of specific radiological features and other key characteristics. To improve awareness of AT/RT on the differential diagnosis of intracranial lesions among clinicians, we present this report and briefly summarize previous cases.

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Paediatric Brain Tumours: Rare Variants

Lim

Qiu

Low

et al. 2022

Pediatric Neurosurgery for Clinicians

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Adult Pineal Region Atypical Teratoid Rhabdoid Tumor: A Case for Aggressive Surgical and Chemoradiation Management with Comprehensive Literature Review

Cited by 7 publications

References 64 publications

A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review

Paediatric Brain Tumours: Rare Variants

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