Adult onset Still's disease accompanied by acute respiratory distress syndrome: A case report

Abstract

Abstract. Adult onset Still's disease (AOSD) is a systemic inflammatory disorder characterized by rash, leukocytosis, fever and arthralgia/arthritis. The most common pulmonary manifestations associated with AOSD are pulmonary infiltrates and pleural effusion. The present study describes a 40-year-old male with AOSD who developed fever, sore throat and shortness of breath. Difficulty breathing promptly developed, and the patient was diagnosed with acute respiratory distress syndrome (ARDS). The patient did not respond to antibiotics, including imipenem, vancomycin, fluconazole, moxifloxacin, penicillin, doxycycline and meropenem, but was sensitive to glucocorticoid treatment, including methylprednisolone sodium succinate. ARDS accompanied by AOSD has been rarely reported in the literature. In conclusion, in a patient with ARDS who does not respond to antibiotic treatment, the involvement of AOSD should be considered.

Targeting the Immune System for Pulmonary Inflammation and Cardiovascular Complications in COVID-19 Patients

“…Even if ARDS can be a life-threatening complication for patients with AOSD (153)(154)(155)(156), there is no available evidence supporting the efficacy of IL-1 inhibition in such situations. However, it is reasonable that IL-1β and IL-18 may have a prominent role in acute lung injury possibly linked to inflammasome activation mediated by both infectious stimuli and mechanic ventilation (157).…”