Adult-Onset Recurrent Respiratory Papillomatosis

Taliercio, Sal; Cespedes, Michelle; Born, Hayley; Ruiz, Ryan; Roof, Scott; Amin, Milan R.; Branski, Ryan C.

doi:10.1001/jamaoto.2014.2826

Cited by 52 publications

(21 citation statements)

References 56 publications

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“… 3 , 15 , 16 ) The adult form begins after the age of 20, being more common in males in the third or fourth decades of life. 3 , 4 , 9 , 17 , 18 ) Orlamd et al, 19 studying 224 patients, found that 174 (77.7%) had the juvenile form of the disease, whereas 50 (22.3%) had the adult form. Among the children in that study, 81% were male.…”

Section: Discussionmentioning

confidence: 99%

Laryngotracheobronchial papillomatosis: chest CT findings

et al. 2017

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To evaluate the findings on chest CTs in 16 patients (8 men and 8 women) with laryngotracheobronchial papillomatosis. Methods:This was a retrospective study involving patients ranging from 2 to 72 years of age. The evaluation of the CT scans was independently performed by two observers, and discordant results were resolved by consensus. The inclusion criteria were presence of abnormalities on the CT scans, and the diagnosis was confirmed by anatomopathological examination of the papillomatous lesions. Results:The most common symptoms were hoarseness, cough, dyspnea, and recurrent respiratory infections. The major CT findings were nodular formations in the trachea, solid or cavitated nodules in the lung parenchyma, air trapping, masses, and consolidation. Nodular formations in the trachea were observed in 14 patients (87.5%). Only 2 patients had lesions in lung parenchyma without tracheal involvement. Only 1 patient had no pulmonary dissemination of the disease, showing airway involvement only. Solid and cavitated lung nodules were observed in 14 patients (87.5%) and 13 (81.2%), respectively. Masses were observed in 6 patients (37.5%); air trapping, in 3 (18.7%); consolidation in 3 (18.7%); and pleural effusion, in 1 (6.3%). Pulmonary involvement was bilateral in all cases. Conclusions:The most common tomography findings were nodular formations in the trachea, as well as solid or cavitated nodules and masses in the lung parenchyma. Malignant transformation of the lesions was observed in 5 cases.

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Section: Discussionmentioning

confidence: 99%

Laryngotracheobronchial papillomatosis: chest CT findings

et al. 2017

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“…Second, high-risk HPV 18, and in rare cases other high-risk mucosal types and low-risk mucosal HPV 6 and 11 were detected in the HNSCC ( Gillison et al , 2000 ; Kreimer et al , 2005 ). However, the latter two types predominantly cause papillomas of the respiratory and the laryngeal tract, including recurrent respiratory papillomatosis, a rare disease in children and adults that due to extensive warty growths in the upper airway and dissemination to bronchi, may cause significant airway obstruction and may undergo malignant transformation ( Venkatesan et al , 2012 ; Taliercio et al , 2015 ).…”

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confidence: 99%

Human papillomavirus vaccination induces neutralising antibodies in oral mucosal fluids

et al. 2016

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Background:Mucosal human papillomaviruses (HPV) are a major cause of cancers and papillomas of the anogenital and oropharyngeal tract. HPV-vaccination elicits neutralising antibodies in sera and cervicovaginal secretions and protects uninfected individuals from persistent anogenital infection and associated diseases caused by the vaccine-targeted HPV types. Whether immunisation can prevent oropharyngeal infection and diseases and whether neutralising antibodies represent the correlate of protection, is still unclear.Methods:We determined IgG and neutralising antibodies against low-risk HPV6 and high-risk HPV16/18 in sera and oral fluids from healthy females (n=20) before and after quadrivalent HPV-vaccination and compared the results with non-vaccinated controls.Results:HPV-vaccination induced type-specific antibodies in sera and oral fluids of the vaccinees. Importantly, the antibodies in oral fluids were capable of neutralising HPV pseudovirions in vitro, indicating protection from infection. The increased neutralising antibody levels against HPV16/18 in sera and oral fluids post-vaccination correlated significantly within an individual.Conclusions:We provide experimental proof that HPV-vaccination elicits neutralising antibodies to the vaccine-targeted types in oral fluids. Hence, immunisation may confer direct protection against type-specific HPV infection and associated diseases of the oropharyngeal tract. Measurement of antibodies in oral fluids represents a suitable tool to assess vaccine-induced protection within the mucosal milieu of the orophayrynx.

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“…Some data question the dogma that active and passive smoking plays a role in recidivistic disease [15–17]. Several authors have also questioned the role of laryngopharyngeal reflux (LPR), mainly because of the lack of well-designed studies and less than ideal diagnostic methods of LPR, which were mostly limited to questionnaires or indirect signs of reflux, in existing studies [16, 18, 19].…”

Section: Introductionmentioning

confidence: 99%

Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis

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Jančatová

et al. 2019

BioMed Research International

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Introduction. Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP is low. It is likely that other factors contribute to the pathogenesis of JORRP, during either activation or reactivation of a latent HPV infection. There is evidence that laryngopharyngeal reflux (LPR) might be such a risk factor for adult-onset recurrent respiratory papillomatosis. This study investigated if LPR might also be a risk factor for JORRP. Materials and Methods. Children with JORRP of the larynx that required microlaryngoscopy at a tertiary referral hospital were included in this prospective case-series study from November 2015 to November 2017. Using immunohistochemistry, HPV infection and pepsin associated with LPR were diagnosed from laryngeal biopsies. Results. Eleven children (aged 4-14 years) were analyzed. No patient had a history of immunodeficiency or tobacco smoke exposure. All patients underwent at least three previous surgeries due to JORRP and had been vaccinated against HPV in the past. Five children were treated using antivirotics and immunomodulators. The only known maternal risk factor was that three mothers were primiparous. All 11 samples were infected with HPV (type 6 or 11). Pathologic LPR was diagnosed in 5/11 children (45.5%). Conclusion. LPR may be a risk factor for JORRP, contributing to its development by activating or reactivating a latent HPV infection. Results are in accordance with those from our previous study in adults.

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Adult-Onset Recurrent Respiratory Papillomatosis

Cited by 52 publications

References 56 publications

Laryngotracheobronchial papillomatosis: chest CT findings

Laryngotracheobronchial papillomatosis: chest CT findings

Human papillomavirus vaccination induces neutralising antibodies in oral mucosal fluids

Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis

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